astrocytoma Gene Set

Dataset GWASdb SNP-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description A glial tumor of the brain or spinal cord showing astrocytic differentiation. It includes the following clinicopathological entities: pilocytic astrocytoma, diffuse astrocytoma, anaplastic astrocytoma, pleomorphic xanthoastrocytoma, subependymal giant cell astrocytoma, and glioblastoma.|Neoplasms of the brain and spinal cord derived from glial cells which vary from histologically benign forms to highly anaplastic and malignant tumors. Fibrillary astrocytomas are the most common type and may be classified in order of increasing malignancy (grades I through IV). In the first two decades of life, astrocytomas tend to originate in the cerebellar hemispheres; in adults, they most frequently arise in the cerebrum and frequently undergo malignant transformation (MeSH).|Neoplasms of the brain and spinal cord derived from glial cells which vary from histologically benign forms to highly anaplastic and malignant tumors. Fibrillary astrocytomas are the most common type and may be classified in order of increasing malignancy (grades I through IV). In the first two decades of life, astrocytomas tend to originate in the cerebellar hemispheres; in adults, they most frequently arise in the cerebrum and frequently undergo malignant transformation. (From Devita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2013-7; Holland et al., Cancer Medicine, 3d ed, p1082) (Experimental Factor Ontology, EFO_0000272)
External Link http://jjwanglab.org/gwasdb/gwasdb2/gwasdb2/go_trait/HP:0009592
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Genes

66 genes associated with the astrocytoma phenotype in GWAS datasets from the GWASdb SNP-Phenotype Associations dataset.

Symbol Name Standardized Value
SSBP2 single-stranded DNA binding protein 2 1.04365
USP10 ubiquitin specific peptidase 10 0.899912
APBA2 amyloid beta (A4) precursor protein-binding, family A, member 2 0.899912
KAT2B K(lysine) acetyltransferase 2B 0.882984
LINC00189 long intergenic non-protein coding RNA 189 0.868241
DCC DCC netrin 1 receptor 0.855449
ABCC1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 0.846368
FARP1 FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived) 0.838165
CACNA1C calcium channel, voltage-dependent, L type, alpha 1C subunit 0.834343
OGFRL1 opioid growth factor receptor-like 1 0.821408
FRMD8 FERM domain containing 8 0.819829
PCSK6 proprotein convertase subtilisin/kexin type 6 0.801631
IQSEC3 IQ motif and Sec7 domain 3 0.790435
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.788506
MAN1B1 mannosidase, alpha, class 1B, member 1 0.773374
SHROOM3 shroom family member 3 0.770746
LOC146513 uncharacterized LOC146513 0.770746
ZMYND15 zinc finger, MYND-type containing 15 0.764625
TTYH1 tweety family member 1 0.752816
LOC100507195 uncharacterized LOC100507195 0.750909
BTNL2 butyrophilin-like 2 0.73587
ALKBH6 alkB, alkylation repair homolog 6 (E. coli) 0.726891
DOCK1 dedicator of cytokinesis 1 0.72096
CLIP3 CAP-GLY domain containing linker protein 3 0.714303
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.711145
SCARB1 scavenger receptor class B, member 1 0.695366
PTPRO protein tyrosine phosphatase, receptor type, O 0.686028
PAQR5 progestin and adipoQ receptor family member V 0.685437
GPA33 glycoprotein A33 (transmembrane) 0.685142
ADARB2 adenosine deaminase, RNA-specific, B2 (non-functional) 0.681114
AIFM2 apoptosis-inducing factor, mitochondrion-associated, 2 0.677826
SP100 SP100 nuclear antigen 0.676017
GTSF1 gametocyte specific factor 1 0.667145
RNF168 ring finger protein 168, E3 ubiquitin protein ligase 0.665245
FAM13A family with sequence similarity 13, member A 0.66233
DPH6 diphthamine biosynthesis 6 0.660775
FOXP1 forkhead box P1 0.653106
MRPL23 mitochondrial ribosomal protein L23 0.653106
ARHGEF10 Rho guanine nucleotide exchange factor (GEF) 10 0.647367
PPA2 pyrophosphatase (inorganic) 2 0.633071
DLG2 discs, large homolog 2 (Drosophila) 0.615351
PARK2 parkin RBR E3 ubiquitin protein ligase 0.613645
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 0.613269
NUDT3 nudix (nucleoside diphosphate linked moiety X)-type motif 3 0.612337
PITPNM3 PITPNM family member 3 0.611781
DOCK5 dedicator of cytokinesis 5 0.609228
CDH23 cadherin-related 23 0.606913
DGKI diacylglycerol kinase, iota 0.602943
TMEM222 transmembrane protein 222 0.602268
CEP128 centrosomal protein 128kDa 0.599613
DAB1 Dab, reelin signal transducer, homolog 1 (Drosophila) 0.593884
PKHD1 polycystic kidney and hepatic disease 1 (autosomal recessive) 0.593267
GABRB1 gamma-aminobutyric acid (GABA) A receptor, beta 1 0.59159
AADACL3 arylacetamide deacetylase-like 3 0.590389
ARID1A AT rich interactive domain 1A (SWI-like) 0.585012
INSC inscuteable homolog (Drosophila) 0.583544
LOXHD1 lipoxygenase homology domains 1 0.581504
MARCH1 membrane-associated ring finger (C3HC4) 1, E3 ubiquitin protein ligase 0.581268
MTHFR methylenetetrahydrofolate reductase (NAD(P)H) 0.579744
SLIT3 slit homolog 3 (Drosophila) 0.578934
MROH2A maestro heat-like repeat family member 2A 0.578475
RAI1 retinoic acid induced 1 0.578018
MTUS1 microtubule associated tumor suppressor 1 0.576214
ADGRB3 adhesion G protein-coupled receptor B3 0.576102
SASH1 SAM and SH3 domain containing 1 0.573794
ONECUT2 one cut homeobox 2 0.57293