astrocytomas Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description A glial tumor of the brain or spinal cord showing astrocytic differentiation. It includes the following clinicopathological entities: pilocytic astrocytoma, diffuse astrocytoma, anaplastic astrocytoma, pleomorphic xanthoastrocytoma, subependymal giant cell astrocytoma, and glioblastoma.|Neoplasms of the brain and spinal cord derived from glial cells which vary from histologically benign forms to highly anaplastic and malignant tumors. Fibrillary astrocytomas are the most common type and may be classified in order of increasing malignancy (grades I through IV). In the first two decades of life, astrocytomas tend to originate in the cerebellar hemispheres; in adults, they most frequently arise in the cerebrum and frequently undergo malignant transformation (MeSH).|Neoplasms of the brain and spinal cord derived from glial cells which vary from histologically benign forms to highly anaplastic and malignant tumors. Fibrillary astrocytomas are the most common type and may be classified in order of increasing malignancy (grades I through IV). In the first two decades of life, astrocytomas tend to originate in the cerebellar hemispheres; in adults, they most frequently arise in the cerebrum and frequently undergo malignant transformation. (From Devita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2013-7; Holland et al., Cancer Medicine, 3d ed, p1082) (Experimental Factor Ontology, EFO_0000272)
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Genes

138 genes co-occuring with the biological term astrocytomas in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ACTN1 actinin, alpha 1
ACTN4 actinin, alpha 4
ADAR adenosine deaminase, RNA-specific
ADARB1 adenosine deaminase, RNA-specific, B1
AKAP12 A kinase (PRKA) anchor protein 12
ANGPT1 angiopoietin 1
AQP1 aquaporin 1 (Colton blood group)
AQP4 aquaporin 4
AQP8 aquaporin 8
ATAD3B ATPase family, AAA domain containing 3B
ATP6V0A4 ATPase, H+ transporting, lysosomal V0 subunit a4
ATRX alpha thalassemia/mental retardation syndrome X-linked
AURKA aurora kinase A
BCL2L1 BCL2-like 1
BDNF brain-derived neurotrophic factor
BLCAP bladder cancer associated protein
BRAF B-Raf proto-oncogene, serine/threonine kinase
BRINP1 bone morphogenetic protein/retinoic acid inducible neural-specific 1
BSG basigin (Ok blood group)
CA12 carbonic anhydrase XII
CAV1 caveolin 1, caveolae protein, 22kDa
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CDKN2A cyclin-dependent kinase inhibitor 2A
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CFL1 cofilin 1 (non-muscle)
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CNR1 cannabinoid receptor 1 (brain)
CNR2 cannabinoid receptor 2 (macrophage)
COL6A1 collagen, type VI, alpha 1
CREB1 cAMP responsive element binding protein 1
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CXCR2 chemokine (C-X-C motif) receptor 2
DDIT3 DNA-damage-inducible transcript 3
DMBT1 deleted in malignant brain tumors 1
DUT deoxyuridine triphosphatase
E2F2 E2F transcription factor 2
EGFR epidermal growth factor receptor
EGR1 early growth response 1
EPAS1 endothelial PAS domain protein 1
EPHA2 EPH receptor A2
ERBB2 erb-b2 receptor tyrosine kinase 2
ERCC1 excision repair cross-complementation group 1
FASTK Fas-activated serine/threonine kinase
FGFR4 fibroblast growth factor receptor 4
FLT1 fms-related tyrosine kinase 1
FOSL1 FOS-like antigen 1
FOXO1 forkhead box O1
FRAT1 frequently rearranged in advanced T-cell lymphomas 1
GFAP glial fibrillary acidic protein
GLUL glutamate-ammonia ligase
GSTP1 glutathione S-transferase pi 1
H3F3A H3 histone, family 3A
HDAC5 histone deacetylase 5
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HIPK2 homeodomain interacting protein kinase 2
HOXC9 homeobox C9
HRAS Harvey rat sarcoma viral oncogene homolog
ICAM1 intercellular adhesion molecule 1
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGFBP3 insulin-like growth factor binding protein 3
IL13RA2 interleukin 13 receptor, alpha 2
IL6 interleukin 6
ITGB8 integrin, beta 8
KCNA5 potassium channel, voltage gated shaker related subfamily A, member 5
KDR kinase insert domain receptor
KIAA1549 KIAA1549
KRAS Kirsten rat sarcoma viral oncogene homolog
LAMP1 lysosomal-associated membrane protein 1
LHX9 LIM homeobox 9
MAP2 microtubule-associated protein 2
MBP myelin basic protein
MELK maternal embryonic leucine zipper kinase
MET MET proto-oncogene, receptor tyrosine kinase
MGMT O-6-methylguanine-DNA methyltransferase
MIB1 mindbomb E3 ubiquitin protein ligase 1
MIR106A microRNA 106a
MIR124-3 microRNA 124-3
MIR128-1 microRNA 128-1
MIR221 microRNA 221
MIR93 microRNA 93
MKI67 marker of proliferation Ki-67
MLH1 mutL homolog 1
MSH2 mutS homolog 2
MSN moesin
MTOR mechanistic target of rapamycin (serine/threonine kinase)
MYC v-myc avian myelocytomatosis viral oncogene homolog
NDRG2 NDRG family member 2
NES nestin
NEWENTRY Record to support submission of GeneRIFs for a gene not in Gene (human; man).
NF1 neurofibromin 1
NGFR nerve growth factor receptor
NOV nephroblastoma overexpressed
NPAS3 neuronal PAS domain protein 3
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin)
NRAS neuroblastoma RAS viral (v-ras) oncogene homolog
NTRK1 neurotrophic tyrosine kinase, receptor, type 1
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
NTRK3 neurotrophic tyrosine kinase, receptor, type 3
NUMB numb homolog (Drosophila)
OLIG1 oligodendrocyte transcription factor 1
OLIG2 oligodendrocyte lineage transcription factor 2
PARK7 parkinson protein 7
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PEBP1 phosphatidylethanolamine binding protein 1
PECAM1 platelet/endothelial cell adhesion molecule 1
PGK1 phosphoglycerate kinase 1
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PML promyelocytic leukemia
POLG polymerase (DNA directed), gamma
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D
PRND prion protein 2 (dublet)
PTEN phosphatase and tensin homolog
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTN pleiotrophin
RASL10A RAS-like, family 10, member A
RHOA ras homolog family member A
RPSA ribosomal protein SA
RRAS related RAS viral (r-ras) oncogene homolog
SIRPA signal-regulatory protein alpha
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPHK1 sphingosine kinase 1
SPP1 secreted phosphoprotein 1
STS steroid sulfatase (microsomal), isozyme S
TERT telomerase reverse transcriptase
TFAM transcription factor A, mitochondrial
TGFB1 transforming growth factor, beta 1
TNC tenascin C
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase
TNR tenascin R
TP53 tumor protein p53
TRPV1 transient receptor potential cation channel, subfamily V, member 1
TSC1 tuberous sclerosis 1
TSC2 tuberous sclerosis 2
TUBG1 tubulin, gamma 1
WNT1 wingless-type MMTV integration site family, member 1
XRCC3 X-ray repair complementing defective repair in Chinese hamster cells 3