atf2 Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description activating transcription factor 2|This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions This protein binds to the cAMP-responsive element (CRE), an octameric palindrome. It forms a homodimer or a heterodimer with c-Jun and stimulates CRE-dependent transcription. This protein is also a histone acetyltransferase (HAT) that specifically acetylates histones H2B and H4 in vitro; thus it may represent a class of sequence-specific factors that activate transcription by direct effects on chromatin components. The encoded protein may also be involved in cell's DNA damage response independent of its role in transcriptional regulation. Several alternatively spliced transcript variants have been found for this gene [provided by RefSeq, Jan 2014] (NCBI Entrez Gene Database, 1386)
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Genes

51 genes co-occuring with the biological term atf2 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ADRB2 adrenoceptor beta 2, surface
ATF2 activating transcription factor 2
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
ATF7 activating transcription factor 7
ATM ATM serine/threonine kinase
CREB1 cAMP responsive element binding protein 1
CTGF connective tissue growth factor
CXCL8 chemokine (C-X-C motif) ligand 8
DDIT3 DNA-damage-inducible transcript 3
DUSP1 dual specificity phosphatase 1
DUSP10 dual specificity phosphatase 10
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSL2 FOS-like antigen 2
GAS6 growth arrest-specific 6
GSTP1 glutathione S-transferase pi 1
HBG1 hemoglobin, gamma A
HDAC3 histone deacetylase 3
HMOX1 heme oxygenase 1
IL1B interleukin 1, beta
IL23A interleukin 23, alpha subunit p19
INS insulin
JUN jun proto-oncogene
KLF2 Kruppel-like factor 2
MAFA v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog A
MAPK14 mitogen-activated protein kinase 14
MAPK8 mitogen-activated protein kinase 8
MAPK9 mitogen-activated protein kinase 9
MAPKAP1 mitogen-activated protein kinase associated protein 1
MIR26B microRNA 26b
MIR29A microRNA 29a
MITF microphthalmia-associated transcription factor
MMP2 matrix metallopeptidase 2
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYLK myosin light chain kinase
NCOA6 nuclear receptor coactivator 6
NEUROD1 neuronal differentiation 1
PDX1 pancreatic and duodenal homeobox 1
PLK3 polo-like kinase 3
PRKCE protein kinase C, epsilon
PTEN phosphatase and tensin homolog
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
RETN resistin
SNAI2 snail family zinc finger 2
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
TCF7 transcription factor 7 (T-cell specific, HMG-box)
TP53 tumor protein p53
VEGFA vascular endothelial growth factor A
VRK1 vaccinia related kinase 1
YTHDC2 YTH domain containing 2