atf4 Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description activating transcription factor 4|This gene encodes a transcription factor that was originally identified as a widely expressed mammalian DNA binding protein that could bind a tax-responsive enhancer element in the LTR of HTLV-1. The encoded protein was also isolated and characterized as the cAMP-response element binding protein 2 (CREB-2). The protein encoded by this gene belongs to a family of DNA-binding proteins that includes the AP-1 family of transcription factors, cAMP-response element binding proteins (CREBs) and CREB-like proteins. These transcription factors share a leucine zipper region that is involved in protein-protein interactions, located C-terminal to a stretch of basic amino acids that functions as a DNA binding domain. Two alternative transcripts encoding the same protein have been described. Two pseudogenes are located on the X chromosome at q28 in a region containing a large inverted duplication. [provided by RefSeq, Sep 2011] (NCBI Entrez Gene Database, 468)
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Genes

69 genes co-occuring with the biological term atf4 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
AHR aryl hydrocarbon receptor
APOE apolipoprotein E
AR androgen receptor
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF2 activating transcription factor 2
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
ATF5 activating transcription factor 5
ATF6 activating transcription factor 6
BGLAP bone gamma-carboxyglutamate (gla) protein
BTRC beta-transducin repeat containing E3 ubiquitin protein ligase
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CEBPE CCAAT/enhancer binding protein (C/EBP), epsilon
CENPF centromere protein F, 350/400kDa
CEP290 centrosomal protein 290kDa
CREB1 cAMP responsive element binding protein 1
CREBBP CREB binding protein
CSNK2A1 casein kinase 2, alpha 1 polypeptide
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DISC1 disrupted in schizophrenia 1
EGLN2 egl-9 family hypoxia-inducible factor 2
EGLN3 egl-9 family hypoxia-inducible factor 3
EIF1AX eukaryotic translation initiation factor 1A, X-linked
EIF2A eukaryotic translation initiation factor 2A, 65kDa
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3
EIF2AK4 eukaryotic translation initiation factor 2 alpha kinase 4
EIF2S1 eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa
ELAVL1 ELAV like RNA binding protein 1
EP300 E1A binding protein p300
EPO erythropoietin
F7 coagulation factor VII (serum prothrombin conversion accelerator)
FGF21 fibroblast growth factor 21
GPT2 glutamic pyruvate transaminase (alanine aminotransferase) 2
HDAC4 histone deacetylase 4
HRK harakiri, BCL2 interacting protein
IGF1 insulin-like growth factor 1 (somatomedin C)
IGFBP1 insulin-like growth factor binding protein 1
MAPK14 mitogen-activated protein kinase 14
MIR663A microRNA 663a
MTOR mechanistic target of rapamycin (serine/threonine kinase)
MYCN v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog
NACA nascent polypeptide-associated complex alpha subunit
NDC80 NDC80 kinetochore complex component
NFE2L2 nuclear factor, erythroid 2-like 2
NUPR1 nuclear protein, transcriptional regulator, 1
POLR2C polymerase (RNA) II (DNA directed) polypeptide C, 33kDa
PRKDC protein kinase, DNA-activated, catalytic polypeptide
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
ROCK1 Rho-associated, coiled-coil containing protein kinase 1
RPL41 ribosomal protein L41
RUNX2 runt-related transcription factor 2
SIRT1 sirtuin 1
SLC1A5 solute carrier family 1 (neutral amino acid transporter), member 5
SLC38A2 solute carrier family 38, member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SLC7A6 solute carrier family 7 (amino acid transporter light chain, y+L system), member 6
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
TFAP4 transcription factor AP-4 (activating enhancer binding protein 4)
TLR4 toll-like receptor 4
TRIB3 tribbles pseudokinase 3
TXLNG taxilin gamma
TXNIP thioredoxin interacting protein
ULK1 unc-51 like autophagy activating kinase 1
VCAM1 vascular cell adhesion molecule 1
VEGFA vascular endothelial growth factor A
XBP1 X-box binding protein 1