atf6 Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description activating transcription factor 6|This gene encodes a transcription factor that activates target genes for the unfolded protein response (UPR) during endoplasmic reticulum (ER) stress. Although it is a transcription factor, this protein is unusual in that it is synthesized as a transmembrane protein that is embedded in the ER. It functions as an ER stress sensor/transducer, and following ER stress-induced proteolysis, it functions as a nuclear transcription factor via a cis-acting ER stress response element (ERSE) that is present in the promoters of genes encoding ER chaperones. This protein has been identified as a survival factor for quiescent but not proliferative squamous carcinoma cells. There have been conflicting reports about the association of polymorphisms in this gene with diabetes in different populations, but another polymorphism has been associated with increased plasma cholesterol levels. This gene is also thought to be a potential therapeutic target for cystic fibrosis. [provided by RefSeq, Aug 2011] (NCBI Entrez Gene Database, 22926)
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Genes

35 genes co-occuring with the biological term atf6 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ATF4 activating transcription factor 4
ATF6 activating transcription factor 6
BGLAP bone gamma-carboxyglutamate (gla) protein
BMP2 bone morphogenetic protein 2
CCL20 chemokine (C-C motif) ligand 20
CXCL10 chemokine (C-X-C motif) ligand 10
DDIT3 DNA-damage-inducible transcript 3
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3
EIF2S1 eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa
ELL2 elongation factor, RNA polymerase II, 2
EPHX2 epoxide hydrolase 2, cytoplasmic
ERN1 endoplasmic reticulum to nucleus signaling 1
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
IL10 interleukin 10
LEPR leptin receptor
MAP3K5 mitogen-activated protein kinase kinase kinase 5
MAPK1 mitogen-activated protein kinase 1
MBTPS1 membrane-bound transcription factor peptidase, site 1
MBTPS2 membrane-bound transcription factor peptidase, site 2
MCL1 myeloid cell leukemia 1
MIR199A1 microRNA 199a-1
MIR199A2 microRNA 199a-2
MMP9 matrix metallopeptidase 9
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa
ORMDL3 ORMDL sphingolipid biosynthesis regulator 3
PPP1R15A protein phosphatase 1, regulatory subunit 15A
RHO rhodopsin
RTN4 reticulon 4
RUNX2 runt-related transcription factor 2
SEL1L sel-1 suppressor of lin-12-like (C. elegans)
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
STARD4 StAR-related lipid transfer (START) domain containing 4
WBP1 WW domain binding protein 1
XBP1 X-box binding protein 1