atm Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description ATM serine/threonine kinase|The protein encoded by this gene belongs to the PI3/PI4-kinase family. This protein is an important cell cycle checkpoint kinase that phosphorylates; thus, it functions as a regulator of a wide variety of downstream proteins, including tumor suppressor proteins p53 and BRCA1, checkpoint kinase CHK2, checkpoint proteins RAD17 and RAD9, and DNA repair protein NBS1. This protein and the closely related kinase ATR are thought to be master controllers of cell cycle checkpoint signaling pathways that are required for cell response to DNA damage and for genome stability. Mutations in this gene are associated with ataxia telangiectasia, an autosomal recessive disorder. [provided by RefSeq, Aug 2010] (NCBI Entrez Gene Database, 472)
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Genes

192 genes co-occuring with the biological term atm in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ADSS adenylosuccinate synthase
AICDA activation-induced cytidine deaminase
AKT1 v-akt murine thymoma viral oncogene homolog 1
ANXA1 annexin A1
APLF aprataxin and PNKP like factor
ATF2 activating transcription factor 2
ATM ATM serine/threonine kinase
ATMIN ATM interactor
ATR ATR serine/threonine kinase
ATRIP ATR interacting protein
AURKB aurora kinase B
AVEN apoptosis, caspase activation inhibitor
BANP BTG3 associated nuclear protein
BBC3 BCL2 binding component 3
BLM Bloom syndrome, RecQ helicase-like
BMI1 BMI1 proto-oncogene, polycomb ring finger
BRCA1 breast cancer 1, early onset
BRCA2 breast cancer 2, early onset
BRIP1 BRCA1 interacting protein C-terminal helicase 1
CADM1 cell adhesion molecule 1
CASP8 caspase 8, apoptosis-related cysteine peptidase
CASP9 caspase 9, apoptosis-related cysteine peptidase
CCDC6 coiled-coil domain containing 6
CCNB1 cyclin B1
CCND1 cyclin D1
CD24 CD24 molecule
CD44 CD44 molecule (Indian blood group)
CDC25C cell division cycle 25C
CDH3 cadherin 3, type 1, P-cadherin (placental)
CDK1 cyclin-dependent kinase 1
CDK2 cyclin-dependent kinase 2
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN2A cyclin-dependent kinase inhibitor 2A
CDKN2AIP CDKN2A interacting protein
CDT1 chromatin licensing and DNA replication factor 1
CFLAR CASP8 and FADD-like apoptosis regulator
CHEK1 checkpoint kinase 1
CHEK2 checkpoint kinase 2
CHMP1A charged multivesicular body protein 1A
CLU clusterin
CREB1 cAMP responsive element binding protein 1
CREBBP CREB binding protein
CXCL8 chemokine (C-X-C motif) ligand 8
CXCR4 chemokine (C-X-C motif) receptor 4
DBF4 DBF4 zinc finger
DCLRE1A DNA cross-link repair 1A
DCLRE1B DNA cross-link repair 1B
DCLRE1C DNA cross-link repair 1C
DDB2 damage-specific DNA binding protein 2, 48kDa
DMAP1 DNA methyltransferase 1 associated protein 1
DUSP14 dual specificity phosphatase 14
DYRK2 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2
E2F1 E2F transcription factor 1
E2F3 E2F transcription factor 3
EIF3E eukaryotic translation initiation factor 3, subunit E
EP300 E1A binding protein p300
ERC1 ELKS/RAB6-interacting/CAST family member 1
ERCC2 excision repair cross-complementation group 2
ESR1 estrogen receptor 1
FANCA Fanconi anemia, complementation group A
FANCM Fanconi anemia, complementation group M
FAS Fas cell surface death receptor
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
FOXC1 forkhead box C1
FOXE1 forkhead box E1
FOXM1 forkhead box M1
FOXO3 forkhead box O3
GSTP1 glutathione S-transferase pi 1
H2AFX H2A histone family, member X
HDAC1 histone deacetylase 1
HDAC2 histone deacetylase 2
HIPK2 homeodomain interacting protein kinase 2
HNF1A HNF1 homeobox A
HOXB9 homeobox B9
IGF1 insulin-like growth factor 1 (somatomedin C)
IGF2 insulin-like growth factor 2
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma
IL6 interleukin 6
ISG15 ISG15 ubiquitin-like modifier
ITGAV integrin, alpha V
KAT5 K(lysine) acetyltransferase 5
KAT8 K(lysine) acetyltransferase 8
LIG3 ligase III, DNA, ATP-dependent
LY6D lymphocyte antigen 6 complex, locus D
MAP3K7 mitogen-activated protein kinase kinase kinase 7
MAPK1 mitogen-activated protein kinase 1
MAPK14 mitogen-activated protein kinase 14
MAPK3 mitogen-activated protein kinase 3
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2
MATR3 matrin 3
MDC1 mediator of DNA-damage checkpoint 1
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MDM4 MDM4, p53 regulator
MET MET proto-oncogene, receptor tyrosine kinase
MIR100 microRNA 100
MIR181A1 microRNA 181a-1
MIR18A microRNA 18a
MIR421 microRNA 421
MIRLET7A1 microRNA let-7a-1
MIRLET7B microRNA let-7b
MLH1 mutL homolog 1
MRE11A MRE11 meiotic recombination 11 homolog A (S. cerevisiae)
MTOR mechanistic target of rapamycin (serine/threonine kinase)
MYC v-myc avian myelocytomatosis viral oncogene homolog
NBN nibrin
NEK1 NIMA-related kinase 1
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NHEJ1 nonhomologous end-joining factor 1
NUAK1 NUAK family, SNF1-like kinase, 1
PALB2 partner and localizer of BRCA2
PARP1 poly (ADP-ribose) polymerase 1
PAXIP1 PAX interacting (with transcription-activation domain) protein 1
PCNA proliferating cell nuclear antigen
PIDD1 p53-induced death domain protein 1
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PIM1 Pim-1 proto-oncogene, serine/threonine kinase
PIM2 Pim-2 proto-oncogene, serine/threonine kinase
PIM3 Pim-3 proto-oncogene, serine/threonine kinase
PLEKHO1 pleckstrin homology domain containing, family O member 1
PLK1 polo-like kinase 1
PLK3 polo-like kinase 3
PML promyelocytic leukemia
PNKP polynucleotide kinase 3'-phosphatase
PPP2R2B protein phosphatase 2, regulatory subunit B, beta
PPP2R5C protein phosphatase 2, regulatory subunit B', gamma
PRKAA1 protein kinase, AMP-activated, alpha 1 catalytic subunit
PRKAB1 protein kinase, AMP-activated, beta 1 non-catalytic subunit
PRKCA protein kinase C, alpha
PRKDC protein kinase, DNA-activated, catalytic polypeptide
PRNP prion protein
PSME3 proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki)
PTEN phosphatase and tensin homolog
RAD17 RAD17 homolog (S. pombe)
RAD50 RAD50 homolog (S. cerevisiae)
RAD51 RAD51 recombinase
RASSF1 Ras association (RalGDS/AF-6) domain family member 1
RBBP8 retinoblastoma binding protein 8
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
RFWD2 ring finger and WD repeat domain 2, E3 ubiquitin protein ligase
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1
RNF168 ring finger protein 168, E3 ubiquitin protein ligase
RNF8 ring finger protein 8, E3 ubiquitin protein ligase
RPA1 replication protein A1, 70kDa
RPS6 ribosomal protein S6
SATB1 SATB homeobox 1
SET SET nuclear proto-oncogene
SIAH1 siah E3 ubiquitin protein ligase 1
SIRPA signal-regulatory protein alpha
SIRPB2 signal-regulatory protein beta 2
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC22A1 solute carrier family 22 (organic cation transporter), member 1
SLC22A2 solute carrier family 22 (organic cation transporter), member 2
SMAD7 SMAD family member 7
SMC1A structural maintenance of chromosomes 1A
SMC3 structural maintenance of chromosomes 3
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase
SOD2 superoxide dismutase 2, mitochondrial
SP1 Sp1 transcription factor
SRC SRC proto-oncogene, non-receptor tyrosine kinase
STAT5A signal transducer and activator of transcription 5A
STAT5B signal transducer and activator of transcription 5B
STK11 serine/threonine kinase 11
STRAP serine/threonine kinase receptor associated protein
TAOK1 TAO kinase 1
TCL1A T-cell leukemia/lymphoma 1A
TELO2 telomere maintenance 2
TERC telomerase RNA component
TERF1 telomeric repeat binding factor (NIMA-interacting) 1
TERF2 telomeric repeat binding factor 2
TFRC transferrin receptor
TGFB1 transforming growth factor, beta 1
TNF tumor necrosis factor
TOP1 topoisomerase (DNA) I
TP53 tumor protein p53
TP53BP1 tumor protein p53 binding protein 1
TPD52 tumor protein D52
TRIM28 tripartite motif containing 28
TSC2 tuberous sclerosis 2
TTI1 TELO2 interacting protein 1
UBR5 ubiquitin protein ligase E3 component n-recognin 5
WEE1 WEE1 G2 checkpoint kinase
WRN Werner syndrome, RecQ helicase-like
XPC xeroderma pigmentosum, complementation group C
XRCC1 X-ray repair complementing defective repair in Chinese hamster cells 1
XRCC4 X-ray repair complementing defective repair in Chinese hamster cells 4
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)
ZEB1 zinc finger E-box binding homeobox 1
ZFHX3 zinc finger homeobox 3