atm Gene Set

Dataset Phosphosite Textmining Biological Term Annotations
Category structural or functional annotations
Type biological term
Description ATM serine/threonine kinase|The protein encoded by this gene belongs to the PI3/PI4-kinase family. This protein is an important cell cycle checkpoint kinase that phosphorylates; thus, it functions as a regulator of a wide variety of downstream proteins, including tumor suppressor proteins p53 and BRCA1, checkpoint kinase CHK2, checkpoint proteins RAD17 and RAD9, and DNA repair protein NBS1. This protein and the closely related kinase ATR are thought to be master controllers of cell cycle checkpoint signaling pathways that are required for cell response to DNA damage and for genome stability. Mutations in this gene are associated with ataxia telangiectasia, an autosomal recessive disorder. [provided by RefSeq, Aug 2010] (NCBI Entrez Gene Database, 472)
Similar Terms
Downloads & Tools

Genes

138 proteins co-occuring with the biological term atm in abstracts of publications describing phosphosites from the Phosphosite Textmining Biological Term Annotations dataset.

Symbol Name
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ACACA acetyl-CoA carboxylase alpha
AKT1 v-akt murine thymoma viral oncogene homolog 1
APLF aprataxin and PNKP like factor
ATF1 activating transcription factor 1
ATF2 activating transcription factor 2
ATM ATM serine/threonine kinase
ATR ATR serine/threonine kinase
ATRIP ATR interacting protein
AVEN apoptosis, caspase activation inhibitor
BARD1 BRCA1 associated RING domain 1
BCLAF1 BCL2-associated transcription factor 1
BID BH3 interacting domain death agonist
BLM Bloom syndrome, RecQ helicase-like
BRCA1 breast cancer 1, early onset
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
C1QBP complement component 1, q subcomponent binding protein
CBX1 chromobox homolog 1
CCDC6 coiled-coil domain containing 6
CCND1 cyclin D1
CDC25A cell division cycle 25A
CDC25C cell division cycle 25C
CDK1 cyclin-dependent kinase 1
CDK2 cyclin-dependent kinase 2
CEP164 centrosomal protein 164kDa
CHD4 chromodomain helicase DNA binding protein 4
CHEK1 checkpoint kinase 1
CHEK2 checkpoint kinase 2
CHUK conserved helix-loop-helix ubiquitous kinase
CLSPN claspin
CREB1 cAMP responsive element binding protein 1
DAXX death-domain associated protein
DBF4 DBF4 zinc finger
DCK deoxycytidine kinase
DCLRE1C DNA cross-link repair 1C
DYRK2 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2
E2F1 E2F transcription factor 1
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
EP300 E1A binding protein p300
ESR1 estrogen receptor 1
FANCA Fanconi anemia, complementation group A
FANCD2 Fanconi anemia, complementation group D2
FBXO31 F-box protein 31
FOS FBJ murine osteosarcoma viral oncogene homolog
FUS FUS RNA binding protein
GTF2I general transcription factor IIi
H2AFX H2A histone family, member X
HIST1H2AI histone cluster 1, H2ai
HIST1H3A histone cluster 1, H3a
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A)
HORMAD1 HORMA domain containing 1
HORMAD2 HORMA domain containing 2
HSPB1 heat shock 27kDa protein 1
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma
JUN jun proto-oncogene
KAT5 K(lysine) acetyltransferase 5
KHSRP KH-type splicing regulatory protein
LAMTOR5 late endosomal/lysosomal adaptor, MAPK and MTOR activator 5
LIG3 ligase III, DNA, ATP-dependent
MAP3K7 mitogen-activated protein kinase kinase kinase 7
MAPK1 mitogen-activated protein kinase 1
MAPK14 mitogen-activated protein kinase 14
MAPK3 mitogen-activated protein kinase 3
MAPK8 mitogen-activated protein kinase 8
MCM2 minichromosome maintenance complex component 2
MCM3 minichromosome maintenance complex component 3
MDC1 mediator of DNA-damage checkpoint 1
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MDM4 MDM4, p53 regulator
MRE11A MRE11 meiotic recombination 11 homolog A (S. cerevisiae)
NABP2 nucleic acid binding protein 2
NBN nibrin
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NHEJ1 nonhomologous end-joining factor 1
NKX3-1 NK3 homeobox 1
NUAK1 NUAK family, SNF1-like kinase, 1
NUSAP1 nucleolar and spindle associated protein 1
PIDD1 p53-induced death domain protein 1
PNKP polynucleotide kinase 3'-phosphatase
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa
PPM1G protein phosphatase, Mg2+/Mn2+ dependent, 1G
PPP1CA protein phosphatase 1, catalytic subunit, alpha isozyme
PPP1R2 protein phosphatase 1, regulatory (inhibitor) subunit 2
PPP2R5C protein phosphatase 2, regulatory subunit B', gamma
PRKAA1 protein kinase, AMP-activated, alpha 1 catalytic subunit
PRKDC protein kinase, DNA-activated, catalytic polypeptide
PRPF19 pre-mRNA processing factor 19
PTEN phosphatase and tensin homolog
RAD17 RAD17 homolog (S. pombe)
RAD50 RAD50 homolog (S. cerevisiae)
RAD51 RAD51 recombinase
RAD9A RAD9 homolog A (S. pombe)
RASSF1 Ras association (RalGDS/AF-6) domain family member 1
RB1 retinoblastoma 1
RBBP8 retinoblastoma binding protein 8
RFWD2 ring finger and WD repeat domain 2, E3 ubiquitin protein ligase
RNF20 ring finger protein 20, E3 ubiquitin protein ligase
RNF40 ring finger protein 40, E3 ubiquitin protein ligase
RPA2 replication protein A2, 32kDa
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1
RRM2B ribonucleotide reductase M2 B (TP53 inducible)
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SMAD1 SMAD family member 1
SMC1A structural maintenance of chromosomes 1A
SMC3 structural maintenance of chromosomes 3
SP1 Sp1 transcription factor
STAT1 signal transducer and activator of transcription 1, 91kDa
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
STK11 serine/threonine kinase 11
STT3A STT3A, subunit of the oligosaccharyltransferase complex (catalytic)
SYN1 synapsin I
TAOK1 TAO kinase 1
TAOK3 TAO kinase 3
TDP1 tyrosyl-DNA phosphodiesterase 1
TERF1 telomeric repeat binding factor (NIMA-interacting) 1
TERF2 telomeric repeat binding factor 2
THOC5 THO complex 5
THRAP3 thyroid hormone receptor associated protein 3
TLK1 tousled-like kinase 1
TOPBP1 topoisomerase (DNA) II binding protein 1
TP53 tumor protein p53
TP53BP1 tumor protein p53 binding protein 1
TP63 tumor protein p63
TRIM28 tripartite motif containing 28
TTC5 tetratricopeptide repeat domain 5
UIMC1 ubiquitin interaction motif containing 1
USP10 ubiquitin specific peptidase 10
VAMP2 vesicle-associated membrane protein 2 (synaptobrevin 2)
VCP valosin containing protein
WRN Werner syndrome, RecQ helicase-like
XPA xeroderma pigmentosum, complementation group A
XRCC3 X-ray repair complementing defective repair in Chinese hamster cells 3
XRCC4 X-ray repair complementing defective repair in Chinese hamster cells 4
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6
ZNF148 zinc finger protein 148
ZNF420 zinc finger protein 420