atorvastatin Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description A dihydroxy monocarboxylic acid that is a member of the drug class known as statins, used primarily for lowering blood cholesterol and for preventing cardiovascular diseases. (Chemical Entities of Biological Interest Ontology, CHEBI_39548)
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Genes

66 genes co-occuring with the biological term atorvastatin in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
ABCG5 ATP-binding cassette, sub-family G (WHITE), member 5
ABCG8 ATP-binding cassette, sub-family G (WHITE), member 8
ACE angiotensin I converting enzyme
ANGPT2 angiopoietin 2
APOA1 apolipoprotein A-I
APOA2 apolipoprotein A-II
APOB apolipoprotein B
APOC3 apolipoprotein C-III
APOE apolipoprotein E
BGLAP bone gamma-carboxyglutamate (gla) protein
CASP3 caspase 3, apoptosis-related cysteine peptidase
CASP9 caspase 9, apoptosis-related cysteine peptidase
CCL2 chemokine (C-C motif) ligand 2
CD38 CD38 molecule
CD40LG CD40 ligand
CD59 CD59 molecule, complement regulatory protein
CETP cholesteryl ester transfer protein, plasma
COL1A1 collagen, type I, alpha 1
CRP C-reactive protein, pentraxin-related
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5
DKK1 dickkopf WNT signaling pathway inhibitor 1
FOXO1 forkhead box O1
HGF hepatocyte growth factor (hepapoietin A; scatter factor)
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMOX1 heme oxygenase 1
HSF1 heat shock transcription factor 1
ICAM1 intercellular adhesion molecule 1
IL6 interleukin 6
KIF6 kinesin family member 6
KLF2 Kruppel-like factor 2
LEP leptin
LIPG lipase, endothelial
LPL lipoprotein lipase
MAPK8 mitogen-activated protein kinase 8
MMP1 matrix metallopeptidase 1
MMP2 matrix metallopeptidase 2
MMP9 matrix metallopeptidase 9
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYD88 myeloid differentiation primary response 88
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NOS3 nitric oxide synthase 3 (endothelial cell)
NR1H3 nuclear receptor subfamily 1, group H, member 3
NR1I2 nuclear receptor subfamily 1, group I, member 2
OLR1 oxidized low density lipoprotein (lectin-like) receptor 1
PCSK9 proprotein convertase subtilisin/kexin type 9
PLAUR plasminogen activator, urokinase receptor
POR P450 (cytochrome) oxidoreductase
PPARG peroxisome proliferator-activated receptor gamma
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
SCARB1 scavenger receptor class B, member 1
SELP selectin P (granule membrane protein 140kDa, antigen CD62)
SLCO1B1 solute carrier organic anion transporter family, member 1B1
SREBF1 sterol regulatory element binding transcription factor 1
TGM1 transglutaminase 1
TIMP1 TIMP metallopeptidase inhibitor 1
TLR4 toll-like receptor 4
TNF tumor necrosis factor
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
TSC2 tuberous sclerosis 2
UGT1A1 UDP glucuronosyltransferase 1 family, polypeptide A1
VCAM1 vascular cell adhesion molecule 1
VEGFA vascular endothelial growth factor A