atovaquone-4201 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

196 genes differentially expressed following the atovaquone-4201 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADCK2 aarF domain containing kinase 2
ADRB3 adrenoceptor beta 3
AIRE autoimmune regulator
AK5 adenylate kinase 5
ART1 ADP-ribosyltransferase 1
BTBD18 BTB (POZ) domain containing 18
BTRC beta-transducin repeat containing E3 ubiquitin protein ligase
C1ORF105 chromosome 1 open reading frame 105
C2ORF27A chromosome 2 open reading frame 27A
CDH19 cadherin 19, type 2
CHRNA2 cholinergic receptor, nicotinic, alpha 2 (neuronal)
CLEC4E C-type lectin domain family 4, member E
CLIC5 chloride intracellular channel 5
COL4A6 collagen, type IV, alpha 6
COMMD4 COMM domain containing 4
CYHR1 cysteine/histidine-rich 1
DMBT1 deleted in malignant brain tumors 1
DNAJA4 DnaJ (Hsp40) homolog, subfamily A, member 4
DNASE1L3 deoxyribonuclease I-like 3
DRD2 dopamine receptor D2
DTNA dystrobrevin, alpha
EFR3B EFR3 homolog B (S. cerevisiae)
EGR1 early growth response 1
EPB41L1 erythrocyte membrane protein band 4.1-like 1
ERAP1 endoplasmic reticulum aminopeptidase 1
ERC1 ELKS/RAB6-interacting/CAST family member 1
FOXN3 forkhead box N3
FPR1 formyl peptide receptor 1
FRMD1 FERM domain containing 1
FRMD4B FERM domain containing 4B
FUT6 fucosyltransferase 6 (alpha (1,3) fucosyltransferase)
GPR182 G protein-coupled receptor 182
GSTT2 glutathione S-transferase theta 2 (gene/pseudogene)
HAP1 huntingtin-associated protein 1
IFITM1 interferon induced transmembrane protein 1
IGHG1 immunoglobulin heavy constant gamma 1 (G1m marker)
KIF13A kinesin family member 13A
LCMT2 leucine carboxyl methyltransferase 2
LILRA1 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 1
LINC00312 long intergenic non-protein coding RNA 312
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
LY6G6C lymphocyte antigen 6 complex, locus G6C
MEF2D myocyte enhancer factor 2D
MEFV Mediterranean fever
MFAP5 microfibrillar associated protein 5
MMP25 matrix metallopeptidase 25
MMP3 matrix metallopeptidase 3
MST1 macrophage stimulating 1
MX2 MX dynamin-like GTPase 2
NCF4 neutrophil cytosolic factor 4, 40kDa
NDRG2 NDRG family member 2
NF1 neurofibromin 1
NFX1 nuclear transcription factor, X-box binding 1
NPHP1 nephronophthisis 1 (juvenile)
NRP1 neuropilin 1
OAZ3 ornithine decarboxylase antizyme 3
OLR1 oxidized low density lipoprotein (lectin-like) receptor 1
OR1D2 olfactory receptor, family 1, subfamily D, member 2
OSR2 odd-skipped related transciption factor 2
PCSK6 proprotein convertase subtilisin/kexin type 6
PDPR pyruvate dehydrogenase phosphatase regulatory subunit
PKP4 plakophilin 4
PLCH2 phospholipase C, eta 2
PLK4 polo-like kinase 4
PMS2P3 postmeiotic segregation increased 2 pseudogene 3
PNMA3 paraneoplastic Ma antigen 3
PON1 paraoxonase 1
RANBP1 RAN binding protein 1
RARB retinoic acid receptor, beta
RBFOX1 RNA binding protein, fox-1 homolog (C. elegans) 1
RETN resistin
RGS5 regulator of G-protein signaling 5
RHOBTB3 Rho-related BTB domain containing 3
RUFY3 RUN and FYVE domain containing 3
SATB2 SATB homeobox 2
SCAPER S-phase cyclin A-associated protein in the ER
SCD5 stearoyl-CoA desaturase 5
SLC16A10 solute carrier family 16 (aromatic amino acid transporter), member 10
SLCO4C1 solute carrier organic anion transporter family, member 4C1
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1)
SPEG SPEG complex locus
SSTR5 somatostatin receptor 5
STX7 syntaxin 7
SYCP1 synaptonemal complex protein 1
TBRG4 transforming growth factor beta regulator 4
TFCP2L1 transcription factor CP2-like 1
TNFRSF25 tumor necrosis factor receptor superfamily, member 25
TRIM10 tripartite motif containing 10
TTLL4 tubulin tyrosine ligase-like family member 4
UTS2 urotensin 2
VWA5A von Willebrand factor A domain containing 5A
WNK1 WNK lysine deficient protein kinase 1
WSB1 WD repeat and SOCS box containing 1
ZBTB20 zinc finger and BTB domain containing 20
ZIM2 zinc finger, imprinted 2
ZNF287 zinc finger protein 287
ZNF334 zinc finger protein 334
ZNF343 zinc finger protein 343
ZNF639 zinc finger protein 639
ZNF688 zinc finger protein 688

decreased expression

Symbol Name
ABHD8 abhydrolase domain containing 8
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase
ACE angiotensin I converting enzyme
ADAM2 ADAM metallopeptidase domain 2
ARHGAP22 Rho GTPase activating protein 22
ARHGEF16 Rho guanine nucleotide exchange factor (GEF) 16
ARHGEF26 Rho guanine nucleotide exchange factor (GEF) 26
ATAD5 ATPase family, AAA domain containing 5
C1QTNF9B-AS1 C1QTNF9B antisense RNA 1
C22ORF46 chromosome 22 open reading frame 46
CAPN15 calpain 15
CASP5 caspase 5, apoptosis-related cysteine peptidase
CASS4 Cas scaffolding protein family member 4
CBX8 chromobox homolog 8
CCDC106 coiled-coil domain containing 106
CCNT1 cyclin T1
CD68 CD68 molecule
CLDN1 claudin 1
CORO1A coronin, actin binding protein, 1A
CPSF7 cleavage and polyadenylation specific factor 7, 59kDa
CXCL3 chemokine (C-X-C motif) ligand 3
DDIT3 DNA-damage-inducible transcript 3
DMTN dematin actin binding protein
DSPP dentin sialophosphoprotein
ENTPD5 ectonucleoside triphosphate diphosphohydrolase 5
FLJ21369 uncharacterized protein FLJ21369
FOXA1 forkhead box A1
FRMPD1 FERM and PDZ domain containing 1
GALNT14 polypeptide N-acetylgalactosaminyltransferase 14
GIF gastric intrinsic factor (vitamin B synthesis)
GRINA glutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1 (glutamate binding)
GSTA3 glutathione S-transferase alpha 3
HIST1H2AI histone cluster 1, H2ai
HIST1H2AJ histone cluster 1, H2aj
HIST1H2AK histone cluster 1, H2ak
HIST1H2BN histone cluster 1, H2bn
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3
HOXC13 homeobox C13
IRF2BP1 interferon regulatory factor 2 binding protein 1
KANSL3 KAT8 regulatory NSL complex subunit 3
KHDRBS2 KH domain containing, RNA binding, signal transduction associated 2
KIAA0319L KIAA0319-like
KIAA1456 KIAA1456
KLF13 Kruppel-like factor 13
KRT20 keratin 20, type I
KRT86 keratin 86, type II
LIME1 Lck interacting transmembrane adaptor 1
LIMS2 LIM and senescent cell antigen-like domains 2
LOC100287590 uncharacterized LOC100287590
LPAR4 lysophosphatidic acid receptor 4
LRRC61 leucine rich repeat containing 61
LY6D lymphocyte antigen 6 complex, locus D
MAP4K2 mitogen-activated protein kinase kinase kinase kinase 2
MBL1P mannose-binding lectin (protein A) 1, pseudogene
MGP matrix Gla protein
MTCP1 mature T-cell proliferation 1
MTSS1L metastasis suppressor 1-like
MVP major vault protein
MXRA8 matrix-remodelling associated 8
MYL9 myosin, light chain 9, regulatory
MYO1F myosin IF
NARFL nuclear prelamin A recognition factor-like
NOL6 nucleolar protein 6 (RNA-associated)
NOTCH1 notch 1
NSUN6 NOP2/Sun domain family, member 6
NUDT2 nudix (nucleoside diphosphate linked moiety X)-type motif 2
PCDH12 protocadherin 12
PCOLCE procollagen C-endopeptidase enhancer
PCYT2 phosphate cytidylyltransferase 2, ethanolamine
PHC1 polyhomeotic homolog 1 (Drosophila)
PPP2R3B protein phosphatase 2, regulatory subunit B'', beta
PRICKLE3 prickle homolog 3 (Drosophila)
PRSS12 protease, serine, 12 (neurotrypsin, motopsin)
PRSS53 protease, serine, 53
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RUNX1-IT1 RUNX1 intronic transcript 1
S1PR1 sphingosine-1-phosphate receptor 1
SAYSD1 SAYSVFN motif domain containing 1
SBNO2 strawberry notch homolog 2 (Drosophila)
SCIN scinderin
SLN sarcolipin
STEAP4 STEAP family member 4
STIM1 stromal interaction molecule 1
SUGCT succinyl-CoA:glutarate-CoA transferase
TINAGL1 tubulointerstitial nephritis antigen-like 1
TLN1 talin 1
TMPRSS4 transmembrane protease, serine 4
TNS2 tensin 2
TTLL1 tubulin tyrosine ligase-like family member 1
TUBA3C tubulin, alpha 3c
VEGFB vascular endothelial growth factor B
ZNF205 zinc finger protein 205
ZNF408 zinc finger protein 408
ZNF574 zinc finger protein 574
ZNF667 zinc finger protein 667
ZYX zyxin