atovaquone-4786 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

197 genes differentially expressed following the atovaquone-4786 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AAGAB alpha- and gamma-adaptin binding protein
ADGB androglobin
AFF2 AF4/FMR2 family, member 2
AGO4 argonaute RISC catalytic component 4
ALS2CL ALS2 C-terminal like
APC adenomatous polyposis coli
APOL6 apolipoprotein L, 6
BTRC beta-transducin repeat containing E3 ubiquitin protein ligase
CA4 carbonic anhydrase IV
CA5BP1 carbonic anhydrase VB pseudogene 1
CACNA1H calcium channel, voltage-dependent, T type, alpha 1H subunit
CACNG1 calcium channel, voltage-dependent, gamma subunit 1
CADM4 cell adhesion molecule 4
CARD14 caspase recruitment domain family, member 14
CD40 CD40 molecule, TNF receptor superfamily member 5
CEACAM7 carcinoembryonic antigen-related cell adhesion molecule 7
CNTFR ciliary neurotrophic factor receptor
COL14A1 collagen, type XIV, alpha 1
COL1A1 collagen, type I, alpha 1
CSF1 colony stimulating factor 1 (macrophage)
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYP2C9 cytochrome P450, family 2, subfamily C, polypeptide 9
DHRS12 dehydrogenase/reductase (SDR family) member 12
DICER1 dicer 1, ribonuclease type III
DMC1 DNA meiotic recombinase 1
DMWD dystrophia myotonica, WD repeat containing
DOPEY2 dopey family member 2
DPYS dihydropyrimidinase
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
EPHB6 EPH receptor B6
EXOC7 exocyst complex component 7
F5 coagulation factor V (proaccelerin, labile factor)
FAM182B family with sequence similarity 182, member B
FOXL1 forkhead box L1
GABBR2 gamma-aminobutyric acid (GABA) B receptor, 2
GLP1R glucagon-like peptide 1 receptor
GSK3A glycogen synthase kinase 3 alpha
HECW1 HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1
HIST1H3B histone cluster 1, H3b
HOXC5 homeobox C5
HYAL4 hyaluronoglucosaminidase 4
HYMAI hydatidiform mole associated and imprinted (non-protein coding)
IGHG1 immunoglobulin heavy constant gamma 1 (G1m marker)
IL37 interleukin 37
IL5RA interleukin 5 receptor, alpha
ITGB7 integrin, beta 7
KCNH6 potassium channel, voltage gated eag related subfamily H, member 6
KCNJ1 potassium channel, inwardly rectifying subfamily J, member 1
KIAA0125 KIAA0125
KIF25-AS1 KIF25 antisense RNA 1
KLHL22 kelch-like family member 22
KLHL29 kelch-like family member 29
KRT83 keratin 83, type II
LGALS9 lectin, galactoside-binding, soluble, 9
LIMK2 LIM domain kinase 2
LINC00574 long intergenic non-protein coding RNA 574
LMX1B LIM homeobox transcription factor 1, beta
LOXL3 lysyl oxidase-like 3
MAP4K2 mitogen-activated protein kinase kinase kinase kinase 2
MEGF6 multiple EGF-like-domains 6
MXRA5 matrix-remodelling associated 5
NCKIPSD NCK interacting protein with SH3 domain
NDUFB7 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 7, 18kDa
NOX5 NADPH oxidase, EF-hand calcium binding domain 5
NR4A1 nuclear receptor subfamily 4, group A, member 1
NUDC nudC nuclear distribution protein
PHF8 PHD finger protein 8
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHTF2 putative homeodomain transcription factor 2
POLDIP3 polymerase (DNA-directed), delta interacting protein 3
PORCN porcupine homolog (Drosophila)
PRELP proline/arginine-rich end leucine-rich repeat protein
PRKACG protein kinase, cAMP-dependent, catalytic, gamma
RABGAP1L RAB GTPase activating protein 1-like
RAD51B RAD51 paralog B
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RTEL1 regulator of telomere elongation helicase 1
SEMA6A sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A
SGCD sarcoglycan, delta (35kDa dystrophin-associated glycoprotein)
SGK2 serum/glucocorticoid regulated kinase 2
SLAMF7 SLAM family member 7
SLC12A4 solute carrier family 12 (potassium/chloride transporter), member 4
SLC5A2 solute carrier family 5 (sodium/glucose cotransporter), member 2
SLC7A8 solute carrier family 7 (amino acid transporter light chain, L system), member 8
SPINK1 serine peptidase inhibitor, Kazal type 1
SPRR2B small proline-rich protein 2B
SPTLC2 serine palmitoyltransferase, long chain base subunit 2
TBC1D2 TBC1 domain family, member 2
THBS4 thrombospondin 4
TTC38 tetratricopeptide repeat domain 38
UGT2B17 UDP glucuronosyltransferase 2 family, polypeptide B17
VARS valyl-tRNA synthetase
ZFYVE9 zinc finger, FYVE domain containing 9
ZNF3 zinc finger protein 3
ZNF506 zinc finger protein 506
ZNF711 zinc finger protein 711
ZSCAN32 zinc finger and SCAN domain containing 32
ZZEF1 zinc finger, ZZ-type with EF-hand domain 1

decreased expression

Symbol Name
ABHD3 abhydrolase domain containing 3
AMIGO2 adhesion molecule with Ig-like domain 2
ANKRD28 ankyrin repeat domain 28
ANKRD40 ankyrin repeat domain 40
AP5M1 adaptor-related protein complex 5, mu 1 subunit
ARHGAP12 Rho GTPase activating protein 12
ARHGAP29 Rho GTPase activating protein 29
ATAD2B ATPase family, AAA domain containing 2B
AUH AU RNA binding protein/enoyl-CoA hydratase
BRIP1 BRCA1 interacting protein C-terminal helicase 1
C10ORF88 chromosome 10 open reading frame 88
C4ORF19 chromosome 4 open reading frame 19
CASP8AP2 caspase 8 associated protein 2
CCDC91 coiled-coil domain containing 91
CDC73 cell division cycle 73
CEP76 centrosomal protein 76kDa
CHCHD3 coiled-coil-helix-coiled-coil-helix domain containing 3
CHIC2 cysteine-rich hydrophobic domain 2
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1
CMAS cytidine monophosphate N-acetylneuraminic acid synthetase
COX7A2L cytochrome c oxidase subunit VIIa polypeptide 2 like
CRLF3 cytokine receptor-like factor 3
DLEU2 deleted in lymphocytic leukemia 2 (non-protein coding)
DONSON downstream neighbor of SON
E2F8 E2F transcription factor 8
ELOVL4 ELOVL fatty acid elongase 4
ERO1L ERO1-like (S. cerevisiae)
ETAA1 Ewing tumor-associated antigen 1
F8 coagulation factor VIII, procoagulant component
FOXA1 forkhead box A1
FOXJ2 forkhead box J2
GBAS glioblastoma amplified sequence
GHR growth hormone receptor
GPALPP1 GPALPP motifs containing 1
HDAC4 histone deacetylase 4
HNRNPF heterogeneous nuclear ribonucleoprotein F
HSPA2 heat shock 70kDa protein 2
ICK intestinal cell (MAK-like) kinase
ISOC1 isochorismatase domain containing 1
JMJD1C jumonji domain containing 1C
LGR4 leucine-rich repeat containing G protein-coupled receptor 4
LIN7C lin-7 homolog C (C. elegans)
LOC202181 SUMO-interacting motifs containing 1 pseudogene
LRRC16A leucine rich repeat containing 16A
MANEA mannosidase, endo-alpha
MICU2 mitochondrial calcium uptake 2
MOCS2 molybdenum cofactor synthesis 2
MORC3 MORC family CW-type zinc finger 3
MPC1 mitochondrial pyruvate carrier 1
MTERF1 mitochondrial transcription termination factor 1
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric
NCK2 NCK adaptor protein 2
NCSTN nicastrin
NEK4 NIMA-related kinase 4
NEK7 NIMA-related kinase 7
NUDT13 nudix (nucleoside diphosphate linked moiety X)-type motif 13
OAT ornithine aminotransferase
PCMTD2 protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2
PDZRN3 PDZ domain containing ring finger 3
PEX2 peroxisomal biogenesis factor 2
PLGRKT plasminogen receptor, C-terminal lysine transmembrane protein
PPIP5K2 diphosphoinositol pentakisphosphate kinase 2
PTPN13 protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)
QTRT1 queuine tRNA-ribosyltransferase 1
RNF11 ring finger protein 11
RNF141 ring finger protein 141
RPE ribulose-5-phosphate-3-epimerase
SCML1 sex comb on midleg-like 1 (Drosophila)
SELT selenoprotein T
SLBP stem-loop binding protein
SLC6A14 solute carrier family 6 (amino acid transporter), member 14
SNIP1 Smad nuclear interacting protein 1
SPSB1 splA/ryanodine receptor domain and SOCS box containing 1
STARD13 StAR-related lipid transfer (START) domain containing 13
STAU2 staufen double-stranded RNA binding protein 2
STK16 serine/threonine kinase 16
STXBP3 syntaxin binding protein 3
TCEAL1 transcription elongation factor A (SII)-like 1
TFG TRK-fused gene
TGDS TDP-glucose 4,6-dehydratase
TIGAR TP53 induced glycolysis regulatory phosphatase
TMC7 transmembrane channel-like 7
TMEM184C transmembrane protein 184C
TMEM2 transmembrane protein 2
TMEM260 transmembrane protein 260
WASF1 WAS protein family, member 1
WASF3 WAS protein family, member 3
WRB tryptophan rich basic protein
YAF2 YY1 associated factor 2
YEATS4 YEATS domain containing 4
YRDC yrdC N(6)-threonylcarbamoyltransferase domain containing
ZC3H12A zinc finger CCCH-type containing 12A
ZFYVE21 zinc finger, FYVE domain containing 21
ZNF107 zinc finger protein 107
ZNF273 zinc finger protein 273
ZNF652 zinc finger protein 652
ZNF654 zinc finger protein 654
ZNF7 zinc finger protein 7