atr Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description ATR serine/threonine kinase|The protein encoded by this gene belongs the PI3/PI4-kinase family, and is most closely related to ATM, a protein kinase encoded by the gene mutated in ataxia telangiectasia. This protein and ATM share similarity with Schizosaccharomyces pombe rad3, a cell cycle checkpoint gene required for cell cycle arrest and DNA damage repair in response to DNA damage. This kinase has been shown to phosphorylate checkpoint kinase CHK1, checkpoint proteins RAD17, and RAD9, as well as tumor suppressor protein BRCA1. Mutations of this gene are associated with Seckel syndrome. An alternatively spliced transcript variant of this gene has been reported, however, its full length nature is not known. Transcript variants utilizing alternative polyA sites exist. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 545)
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Genes

96 genes co-occuring with the biological term atr in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
AGTR2 angiotensin II receptor, type 2
ASF1A anti-silencing function 1A histone chaperone
ATM ATM serine/threonine kinase
ATR ATR serine/threonine kinase
ATRIP ATR interacting protein
BAX BCL2-associated X protein
BCL6 B-cell CLL/lymphoma 6
BLM Bloom syndrome, RecQ helicase-like
BRCA1 breast cancer 1, early onset
BRCA2 breast cancer 2, early onset
CCNE1 cyclin E1
CDC6 cell division cycle 6
CDK1 cyclin-dependent kinase 1
CDK2 cyclin-dependent kinase 2
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN2A cyclin-dependent kinase inhibitor 2A
CDT1 chromatin licensing and DNA replication factor 1
CHEK1 checkpoint kinase 1
CHEK2 checkpoint kinase 2
CLSPN claspin
DBF4 DBF4 zinc finger
DCLRE1C DNA cross-link repair 1C
DDB2 damage-specific DNA binding protein 2, 48kDa
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
ELAVL1 ELAV like RNA binding protein 1
ERCC1 excision repair cross-complementation group 1
ETV1 ets variant 1
EXO1 exonuclease 1
FANCA Fanconi anemia, complementation group A
FANCD2 Fanconi anemia, complementation group D2
FHIT fragile histidine triad
GADD45A growth arrest and DNA-damage-inducible, alpha
GSK3B glycogen synthase kinase 3 beta
H2AFX H2A histone family, member X
HELQ helicase, POLQ-like
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HIPK2 homeodomain interacting protein kinase 2
HNRNPUL1 heterogeneous nuclear ribonucleoprotein U-like 1
ITFG1 integrin alpha FG-GAP repeat containing 1
ITGAV integrin, alpha V
MAPK1 mitogen-activated protein kinase 1
MAPK3 mitogen-activated protein kinase 3
MCPH1 microcephalin 1
MDC1 mediator of DNA-damage checkpoint 1
MIR185 microRNA 185
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type
MRE11A MRE11 meiotic recombination 11 homolog A (S. cerevisiae)
MSH2 mutS homolog 2
MSH6 mutS homolog 6
MUTYH mutY homolog
MYB v-myb avian myeloblastosis viral oncogene homolog
NBN nibrin
NEK1 NIMA-related kinase 1
NOS3 nitric oxide synthase 3 (endothelial cell)
PARP1 poly (ADP-ribose) polymerase 1
PAXIP1 PAX interacting (with transcription-activation domain) protein 1
PCNA proliferating cell nuclear antigen
PLK1 polo-like kinase 1
PML promyelocytic leukemia
POLH polymerase (DNA directed), eta
PPARG peroxisome proliferator-activated receptor gamma
PPP2CB protein phosphatase 2, catalytic subunit, beta isozyme
PPP2R1A protein phosphatase 2, regulatory subunit A, alpha
PRKDC protein kinase, DNA-activated, catalytic polypeptide
PTEN phosphatase and tensin homolog
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PVR poliovirus receptor
RAD17 RAD17 homolog (S. pombe)
RAD50 RAD50 homolog (S. cerevisiae)
RAD51 RAD51 recombinase
RAD9A RAD9 homolog A (S. pombe)
RHNO1 RAD9-HUS1-RAD1 interacting nuclear orphan 1
RPA1 replication protein A1, 70kDa
RPA2 replication protein A2, 32kDa
SIAH1 siah E3 ubiquitin protein ligase 1
SMARCAL1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a-like 1
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase
SRC SRC proto-oncogene, non-receptor tyrosine kinase
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
TERC telomerase RNA component
TERT telomerase reverse transcriptase
TIPIN TIMELESS interacting protein
TLK1 tousled-like kinase 1
TOP1 topoisomerase (DNA) I
TOPBP1 topoisomerase (DNA) II binding protein 1
TP53 tumor protein p53
TP53BP1 tumor protein p53 binding protein 1
UTP3 UTP3, small subunit (SSU) processome component, homolog (S. cerevisiae)
WEE1 WEE1 G2 checkpoint kinase
WRN Werner syndrome, RecQ helicase-like
XPA xeroderma pigmentosum, complementation group A
XPC xeroderma pigmentosum, complementation group C
XRCC1 X-ray repair complementing defective repair in Chinese hamster cells 1
XRCC3 X-ray repair complementing defective repair in Chinese hamster cells 3
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma
ZBTB17 zinc finger and BTB domain containing 17