atr Gene Set

Dataset Phosphosite Textmining Biological Term Annotations
Category structural or functional annotations
Type biological term
Description ATR serine/threonine kinase|The protein encoded by this gene belongs the PI3/PI4-kinase family, and is most closely related to ATM, a protein kinase encoded by the gene mutated in ataxia telangiectasia. This protein and ATM share similarity with Schizosaccharomyces pombe rad3, a cell cycle checkpoint gene required for cell cycle arrest and DNA damage repair in response to DNA damage. This kinase has been shown to phosphorylate checkpoint kinase CHK1, checkpoint proteins RAD17, and RAD9, as well as tumor suppressor protein BRCA1. Mutations of this gene are associated with Seckel syndrome. An alternatively spliced transcript variant of this gene has been reported, however, its full length nature is not known. Transcript variants utilizing alternative polyA sites exist. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 545)
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Genes

70 proteins co-occuring with the biological term atr in abstracts of publications describing phosphosites from the Phosphosite Textmining Biological Term Annotations dataset.

Symbol Name
AKT1 v-akt murine thymoma viral oncogene homolog 1
ATM ATM serine/threonine kinase
ATR ATR serine/threonine kinase
ATRIP ATR interacting protein
BLM Bloom syndrome, RecQ helicase-like
BRCA1 breast cancer 1, early onset
CBX1 chromobox homolog 1
CCNB1 cyclin B1
CCND1 cyclin D1
CDC25A cell division cycle 25A
CDC25C cell division cycle 25C
CDK1 cyclin-dependent kinase 1
CDK2 cyclin-dependent kinase 2
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN2A cyclin-dependent kinase inhibitor 2A
CEP164 centrosomal protein 164kDa
CHEK1 checkpoint kinase 1
CHEK2 checkpoint kinase 2
CLSPN claspin
CREB1 cAMP responsive element binding protein 1
DBF4 DBF4 zinc finger
DCLRE1C DNA cross-link repair 1C
E2F1 E2F transcription factor 1
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
FANCA Fanconi anemia, complementation group A
FANCD2 Fanconi anemia, complementation group D2
FUS FUS RNA binding protein
H2AFX H2A histone family, member X
HIST1H3A histone cluster 1, H3a
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A)
HORMAD1 HORMA domain containing 1
HORMAD2 HORMA domain containing 2
HSPB1 heat shock 27kDa protein 1
KMT2A lysine (K)-specific methyltransferase 2A
MAPK1 mitogen-activated protein kinase 1
MAPK3 mitogen-activated protein kinase 3
MCM2 minichromosome maintenance complex component 2
MCM3 minichromosome maintenance complex component 3
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MDM4 MDM4, p53 regulator
MRE11A MRE11 meiotic recombination 11 homolog A (S. cerevisiae)
NBN nibrin
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin)
POLH polymerase (DNA directed), eta
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa
PPM1G protein phosphatase, Mg2+/Mn2+ dependent, 1G
PRKDC protein kinase, DNA-activated, catalytic polypeptide
RAD17 RAD17 homolog (S. pombe)
RAD9A RAD9 homolog A (S. pombe)
RASSF1 Ras association (RalGDS/AF-6) domain family member 1
RB1 retinoblastoma 1
RBBP8 retinoblastoma binding protein 8
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
RPA2 replication protein A2, 32kDa
SMARCAL1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a-like 1
SMC1A structural maintenance of chromosomes 1A
SP1 Sp1 transcription factor
STK11 serine/threonine kinase 11
SYN1 synapsin I
THRAP3 thyroid hormone receptor associated protein 3
TICRR TOPBP1-interacting checkpoint and replication regulator
TOPBP1 topoisomerase (DNA) II binding protein 1
TP53 tumor protein p53
TTC5 tetratricopeptide repeat domain 5
VAMP2 vesicle-associated membrane protein 2 (synaptobrevin 2)
VCP valosin containing protein
VIM vimentin
WRN Werner syndrome, RecQ helicase-like
XPA xeroderma pigmentosum, complementation group A
XRCC3 X-ray repair complementing defective repair in Chinese hamster cells 3