aurka Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description aurora kinase A|The protein encoded by this gene is a cell cycle-regulated kinase that appears to be involved in microtubule formation and/or stabilization at the spindle pole during chromosome segregation. The encoded protein is found at the centrosome in interphase cells and at the spindle poles in mitosis. This gene may play a role in tumor development and progression. A processed pseudogene of this gene has been found on chromosome 1, and an unprocessed pseudogene has been found on chromosome 10. Multiple transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 6790)
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Genes

32 genes co-occuring with the biological term aurka in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
AKT1 v-akt murine thymoma viral oncogene homolog 1
AURKA aurora kinase A
AURKB aurora kinase B
AURKC aurora kinase C
BCR breakpoint cluster region
BRCA1 breast cancer 1, early onset
BRCA2 breast cancer 2, early onset
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
CCNE1 cyclin E1
CDK2 cyclin-dependent kinase 2
CHEK2 checkpoint kinase 2
EGFR epidermal growth factor receptor
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
FLT4 fms-related tyrosine kinase 4
GLIPR1 GLI pathogenesis-related 1
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HMMR hyaluronan-mediated motility receptor (RHAMM)
HSPA8 heat shock 70kDa protein 8
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MMP2 matrix metallopeptidase 2
MTDH metadherin
MYCN v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog
NOTCH1 notch 1
NPAT nuclear protein, ataxia-telangiectasia locus
NUPR1 nuclear protein, transcriptional regulator, 1
PDGFRB platelet-derived growth factor receptor, beta polypeptide
PLK1 polo-like kinase 1
PTK2 protein tyrosine kinase 2
PTPRD protein tyrosine phosphatase, receptor type, D
TPX2 TPX2, microtubule-associated