axin1 Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description axin 1|This gene encodes a cytoplasmic protein which contains a regulation of G-protein signaling (RGS) domain and a dishevelled and axin (DIX) domain. The encoded protein interacts with adenomatosis polyposis coli, catenin beta-1, glycogen synthase kinase 3 beta, protein phosphate 2, and itself. This protein functions as a negative regulator of the wingless-type MMTV integration site family, member 1 (WNT) signaling pathway and can induce apoptosis. The crystal structure of a portion of this protein, alone and in a complex with other proteins, has been resolved. Mutations in this gene have been associated with hepatocellular carcinoma, hepatoblastomas, ovarian endometriod adenocarcinomas, and medullablastomas. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Dec 2010] (NCBI Entrez Gene Database, 8312)
Similar Terms
Downloads & Tools

Genes

13 genes co-occuring with the biological term axin1 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
AMER1 APC membrane recruitment protein 1
ANP32A acidic (leucine-rich) nuclear phosphoprotein 32 family, member A
APC adenomatous polyposis coli
AXIN1 axin 1
AXIN2 axin 2
CRMP1 collapsin response mediator protein 1
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
FGF19 fibroblast growth factor 19
LRP5 low density lipoprotein receptor-related protein 5
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase
MYC v-myc avian myelocytomatosis viral oncogene homolog
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
WNT1 wingless-type MMTV integration site family, member 1