axin2 Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description axin 2|The Axin-related protein, Axin2, presumably plays an important role in the regulation of the stability of beta-catenin in the Wnt signaling pathway, like its rodent homologs, mouse conductin/rat axil. In mouse, conductin organizes a multiprotein complex of APC (adenomatous polyposis of the colon), beta-catenin, glycogen synthase kinase 3-beta, and conductin, which leads to the degradation of beta-catenin. Apparently, the deregulation of beta-catenin is an important event in the genesis of a number of malignancies. The AXIN2 gene has been mapped to 17q23-q24, a region that shows frequent loss of heterozygosity in breast cancer, neuroblastoma, and other tumors. Mutations in this gene have been associated with colorectal cancer with defective mismatch repair. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 8313)
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Genes

25 genes co-occuring with the biological term axin2 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
APC adenomatous polyposis coli
AXIN1 axin 1
AXIN2 axin 2
BRAF B-Raf proto-oncogene, serine/threonine kinase
BTRC beta-transducin repeat containing E3 ubiquitin protein ligase
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDX2 caudal type homeobox 2
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
DKK4 dickkopf WNT signaling pathway inhibitor 4
EDARADD EDAR-associated death domain
IDO1 indoleamine 2,3-dioxygenase 1
IGF1R insulin-like growth factor 1 receptor
LEF1 lymphoid enhancer-binding factor 1
MEN1 multiple endocrine neoplasia I
MIR205 microRNA 205
MIR34A microRNA 34a
MLH1 mutL homolog 1
MSX1 msh homeobox 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
PAX9 paired box 9
SNAI1 snail family zinc finger 1
SOX4 SRY (sex determining region Y)-box 4
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TP53 tumor protein p53
WNT10A wingless-type MMTV integration site family, member 10A