axl Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description AXL receptor tyrosine kinase|The protein encoded by this gene is a member of the Tyro3-Axl-Mer (TAM) receptor tyrosine kinase subfamily. The encoded protein possesses an extracellular domain which is composed of two immunoglobulin-like motifs at the N-terminal, followed by two fibronectin type-III motifs. It transduces signals from the extracellular matrix into the cytoplasm by binding to the vitamin K-dependent protein growth arrest-specific 6 (Gas6). This gene may be involved in several cellular functions including growth, migration, aggregation and anti-inflammation in multiple cell types. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jul 2013] (NCBI Entrez Gene Database, 558)
Similar Terms
Downloads & Tools

Genes

42 genes co-occuring with the biological term axl in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ADAM10 ADAM metallopeptidase domain 10
ADAM17 ADAM metallopeptidase domain 17
AGO1 argonaute RISC catalytic component 1
AXL AXL receptor tyrosine kinase
BCL2 B-cell CLL/lymphoma 2
EGFR epidermal growth factor receptor
ELMO2 engulfment and cell motility 2
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FLT3 fms-related tyrosine kinase 3
FOSL1 FOS-like antigen 1
FURIN furin (paired basic amino acid cleaving enzyme)
GAS6 growth arrest-specific 6
GNRH1 gonadotropin-releasing hormone 1 (luteinizing-releasing hormone)
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
IFNA1 interferon, alpha 1
KDR kinase insert domain receptor
MERTK MER proto-oncogene, tyrosine kinase
MET MET proto-oncogene, receptor tyrosine kinase
MIR34A microRNA 34a
MIR374A microRNA 374a
MIR548B microRNA 548b
MZF1 myeloid zinc finger 1
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PRSS8 protease, serine, 8
RANBP9 RAN binding protein 9
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SNAI2 snail family zinc finger 2
SP1 Sp1 transcription factor
SP3 Sp3 transcription factor
SRC SRC proto-oncogene, non-receptor tyrosine kinase
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
TEK TEK tyrosine kinase, endothelial
TNF tumor necrosis factor
TNK2 tyrosine kinase, non-receptor, 2
TNS2 tensin 2
TWIST1 twist family bHLH transcription factor 1
TYRO3 TYRO3 protein tyrosine kinase
VIM vimentin
WWTR1 WW domain containing transcription regulator 1
YAP1 Yes-associated protein 1