azacyclonol-6298 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

198 genes differentially expressed following the azacyclonol-6298 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AMACR alpha-methylacyl-CoA racemase
APOM apolipoprotein M
ARC activity-regulated cytoskeleton-associated protein
ATF3 activating transcription factor 3
BAGE B melanoma antigen
CACNG4 calcium channel, voltage-dependent, gamma subunit 4
CALD1 caldesmon 1
CASZ1 castor zinc finger 1
CD83 CD83 molecule
CD8B CD8b molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CFH complement factor H
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CTNS cystinosin, lysosomal cystine transporter
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL3 chemokine (C-X-C motif) ligand 3
CXCL8 chemokine (C-X-C motif) ligand 8
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DDX58 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
DMBT1 deleted in malignant brain tumors 1
DMTN dematin actin binding protein
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DTX2 deltex 2, E3 ubiquitin ligase
DUSP1 dual specificity phosphatase 1
DUSP10 dual specificity phosphatase 10
EFNA3 ephrin-A3
EGR1 early growth response 1
ELOVL2 ELOVL fatty acid elongase 2
FAM46A family with sequence similarity 46, member A
FASLG Fas ligand (TNF superfamily, member 6)
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila)
GABRR2 gamma-aminobutyric acid (GABA) A receptor, rho 2
GATA2 GATA binding protein 2
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HMOX1 heme oxygenase 1
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HSPA6 heat shock 70kDa protein 6 (HSP70B')
ICAM1 intercellular adhesion molecule 1
IDS iduronate 2-sulfatase
IFI44 interferon-induced protein 44
IFI6 interferon, alpha-inducible protein 6
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IFIT2 interferon-induced protein with tetratricopeptide repeats 2
IFIT3 interferon-induced protein with tetratricopeptide repeats 3
IGHG1 immunoglobulin heavy constant gamma 1 (G1m marker)
IL6 interleukin 6
IL6ST interleukin 6 signal transducer
ISG15 ISG15 ubiquitin-like modifier
JAK2 Janus kinase 2
JUN jun proto-oncogene
KLF4 Kruppel-like factor 4 (gut)
KLF6 Kruppel-like factor 6
KRT34 keratin 34, type I
KRT8P12 keratin 8 pseudogene 12
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2
MT1M metallothionein 1M
MT1X metallothionein 1X
MUC1 mucin 1, cell surface associated
MX1 MX dynamin-like GTPase 1
NEBL nebulette
NPEPL1 aminopeptidase-like 1
NT5M 5',3'-nucleotidase, mitochondrial
NUPR1 nuclear protein, transcriptional regulator, 1
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa
OASL 2'-5'-oligoadenylate synthetase-like
OVOL1 ovo-like zinc finger 1
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
POU5F1B POU class 5 homeobox 1B
PPFIA3 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 3
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PRSS16 protease, serine, 16 (thymus)
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTPN21 protein tyrosine phosphatase, non-receptor type 21
RAD54L2 RAD54-like 2 (S. cerevisiae)
RPP25 ribonuclease P/MRP 25kDa subunit
SAT1 spermidine/spermine N1-acetyltransferase 1
SATB2 SATB homeobox 2
SEC24D SEC24 family member D
SETD8 SET domain containing (lysine methyltransferase) 8
SIGLEC6 sialic acid binding Ig-like lectin 6
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SNAPC4 small nuclear RNA activating complex, polypeptide 4, 190kDa
SUGCT succinyl-CoA:glutarate-CoA transferase
SUGP1 SURP and G patch domain containing 1
TMPRSS15 transmembrane protease, serine 15
TRANK1 tetratricopeptide repeat and ankyrin repeat containing 1
TRIB3 tribbles pseudokinase 3
ULBP1 UL16 binding protein 1
WWOX WW domain containing oxidoreductase
ZBTB7A zinc finger and BTB domain containing 7A
ZC3HAV1 zinc finger CCCH-type, antiviral 1

decreased expression

Symbol Name
ACKR3 atypical chemokine receptor 3
ACOX2 acyl-CoA oxidase 2, branched chain
ACTR3B ARP3 actin-related protein 3 homolog B (yeast)
ARHGAP11A Rho GTPase activating protein 11A
ARHGEF6 Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
ARID3B AT rich interactive domain 3B (BRIGHT-like)
ARSJ arylsulfatase family, member J
BAG4 BCL2-associated athanogene 4
BAHD1 bromo adjacent homology domain containing 1
BCAS4 breast carcinoma amplified sequence 4
BGLAP bone gamma-carboxyglutamate (gla) protein
BLOC1S1 biogenesis of lysosomal organelles complex-1, subunit 1
BOLA1 bolA family member 1
C11ORF73 chromosome 11 open reading frame 73
C11ORF80 chromosome 11 open reading frame 80
C5 complement component 5
CASD1 CAS1 domain containing 1
CASP8AP2 caspase 8 associated protein 2
CCBL1 cysteine conjugate-beta lyase, cytoplasmic
CDADC1 cytidine and dCMP deaminase domain containing 1
CDC42BPB CDC42 binding protein kinase beta (DMPK-like)
CENPQ centromere protein Q
CEP85 centrosomal protein 85kDa
CFAP44 cilia and flagella associated protein 44
CGREF1 cell growth regulator with EF-hand domain 1
CHCHD3 coiled-coil-helix-coiled-coil-helix domain containing 3
CLSPN claspin
CNN2 calponin 2
CNTNAP1 contactin associated protein 1
CNTNAP3B contactin associated protein-like 3B
CRYBB2P1 crystallin, beta B2 pseudogene 1
CST6 cystatin E/M
DCAF17 DDB1 and CUL4 associated factor 17
DCAF4 DDB1 and CUL4 associated factor 4
DLEU2 deleted in lymphocytic leukemia 2 (non-protein coding)
DNA2 DNA replication helicase/nuclease 2
DOLPP1 dolichyldiphosphatase 1
E2F8 E2F transcription factor 8
EAF2 ELL associated factor 2
EEF2KMT eukaryotic elongation factor 2 lysine methyltransferase
EGF epidermal growth factor
FAM50B family with sequence similarity 50, member B
FCHSD2 FCH and double SH3 domains 2
FSD1 fibronectin type III and SPRY domain containing 1
FZD3 frizzled class receptor 3
GNB1L guanine nucleotide binding protein (G protein), beta polypeptide 1-like
GUF1 GUF1 GTPase homolog (S. cerevisiae)
HAUS6 HAUS augmin-like complex, subunit 6
HIST1H3H histone cluster 1, H3h
IGFLR1 IGF-like family receptor 1
KIF16B kinesin family member 16B
KIFC1 kinesin family member C1
LMNB1 lamin B1
LOC202181 SUMO-interacting motifs containing 1 pseudogene
MAGEA6 melanoma antigen family A6
MAPK12 mitogen-activated protein kinase 12
MECR mitochondrial trans-2-enoyl-CoA reductase
MUC7 mucin 7, secreted
MYL5 myosin, light chain 5, regulatory
NDUFAF7 NADH dehydrogenase (ubiquinone) complex I, assembly factor 7
NPM3 nucleophosmin/nucleoplasmin 3
NSUN3 NOP2/Sun domain family, member 3
PACS1 phosphofurin acidic cluster sorting protein 1
PALMD palmdelphin
PCYOX1L prenylcysteine oxidase 1 like
PDSS2 prenyl (decaprenyl) diphosphate synthase, subunit 2
PER3 period circadian clock 3
PIP5K1C phosphatidylinositol-4-phosphate 5-kinase, type I, gamma
PRR7 proline rich 7 (synaptic)
RAB23 RAB23, member RAS oncogene family
RARS arginyl-tRNA synthetase
RASA2 RAS p21 protein activator 2
RBL1 retinoblastoma-like 1
RPE ribulose-5-phosphate-3-epimerase
SCN1B sodium channel, voltage gated, type I beta subunit
SDC3 syndecan 3
SH3BGR SH3 domain binding glutamate-rich protein
SLC12A8 solute carrier family 12, member 8
SLC35C2 solute carrier family 35 (GDP-fucose transporter), member C2
SLC39A1 solute carrier family 39 (zinc transporter), member 1
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase
SNIP1 Smad nuclear interacting protein 1
SPATA7 spermatogenesis associated 7
SPEG SPEG complex locus
TARS2 threonyl-tRNA synthetase 2, mitochondrial (putative)
TENM4 teneurin transmembrane protein 4
TINF2 TERF1 (TRF1)-interacting nuclear factor 2
TLN1 talin 1
TMEM2 transmembrane protein 2
TMEM242 transmembrane protein 242
TRAIP TRAF interacting protein
TTC31 tetratricopeptide repeat domain 31
UGGT2 UDP-glucose glycoprotein glucosyltransferase 2
UXS1 UDP-glucuronate decarboxylase 1
VPS33A vacuolar protein sorting 33 homolog A (S. cerevisiae)
XPNPEP3 X-prolyl aminopeptidase 3, mitochondrial
XYLT2 xylosyltransferase II
ZNF675 zinc finger protein 675
ZNF770 zinc finger protein 770