azoospermia Gene Set

Dataset DISEASES Text-mining Gene-Disease Association Evidence Scores
Category disease or phenotype associations
Type disease
Description A condition of suboptimal concentration of SPERMATOZOA in the ejaculated SEMEN to ensure successful FERTILIZATION of an OVUM. In humans, oligospermia is defined as a sperm count below 20 million per milliliter semen. (Experimental Factor Ontology, EFO_0000279)
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Genes

318 genes co-occuring with the disease azoospermia in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.

Symbol Name Standardized Value
DAZ2 deleted in azoospermia 2 2.56832
DAZ1 deleted in azoospermia 1 2.47369
CDY1B chromodomain protein, Y-linked, 1B 1.953
USP9Y ubiquitin specific peptidase 9, Y-linked 1.92576
CDY1 chromodomain protein, Y-linked, 1 1.8936
SRY sex determining region Y 1.89221
DAZL deleted in azoospermia-like 1.87653
GNRH1 gonadotropin-releasing hormone 1 (luteinizing-releasing hormone) 1.79886
PRM2 protamine 2 1.73778
RBMY1A1 RNA binding motif protein, Y-linked, family 1, member A1 1.71271
CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7) 1.69996
SYCP3 synaptonemal complex protein 3 1.59385
USP26 ubiquitin specific peptidase 26 1.5876
PRM1 protamine 1 1.56933
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked 1.55247
HSFY2 heat shock transcription factor, Y linked 2 1.50447
HSFY1 heat shock transcription factor, Y-linked 1 1.50447
CDY2A chromodomain protein, Y-linked, 2A 1.43464
FSHR follicle stimulating hormone receptor 1.42191
EIF1AY eukaryotic translation initiation factor 1A, Y-linked 1.34853
DDX25 DEAD (Asp-Glu-Ala-Asp) box helicase 25 1.34417
AR androgen receptor 1.32148
TNP2 transition protein 2 (during histone to protamine replacement) 1.32061
ZFY zinc finger protein, Y-linked 1.28785
PRDM9 PR domain containing 9 1.27388
KRTAP9-3 keratin associated protein 9-3 1.2656
H2BFWT H2B histone family, member W, testis-specific 1.26516
EPPIN epididymal peptidase inhibitor 1.2382
ZFX zinc finger protein, X-linked 1.16992
UTY ubiquitously transcribed tetratricopeptide repeat containing, Y-linked 1.16821
PRL prolactin 1.16307
DAZ3 deleted in azoospermia 3 1.15027
GDF6 growth differentiation factor 6 1.14602
AMH anti-Mullerian hormone 1.1439
SIRPG signal-regulatory protein gamma 1.13205
RBMXL2 RNA binding motif protein, X-linked-like 2 1.12867
TSSK6 testis-specific serine kinase 6 1.11687
SHBG sex hormone-binding globulin 1.10804
SPATA25 spermatogenesis associated 25 1.10132
STRA8 stimulated by retinoic acid 8 1.09167
TEX13B testis expressed 13B 1.07908
SPACA4 sperm acrosome associated 4 1.07908
GSG1 germ cell associated 1 1.07908
GTSF1L gametocyte specific factor 1-like 1.07908
FAM71F1 family with sequence similarity 71, member F1 1.07908
TMEM225 transmembrane protein 225 1.07908
RPS4Y2 ribosomal protein S4, Y-linked 2 1.07908
NANOS1 nanos homolog 1 (Drosophila) 1.0606
DDX4 DEAD (Asp-Glu-Ala-Asp) box polypeptide 4 1.04714
TMEM95 transmembrane protein 95 1.04335
DCAF12L1 DDB1 and CUL4 associated factor 12-like 1 1.04335
STPG2 sperm-tail PG-rich repeat containing 2 1.03451
OR2W3 olfactory receptor, family 2, subfamily W, member 3 1.0324
TSPY1 testis specific protein, Y-linked 1 1.02524
TSPYL1 TSPY-like 1 1.02355
RNASE10 ribonuclease, RNase A family, 10 (non-active) 1.01216
TEX15 testis expressed 15 1.00921
TGIF2LX TGFB-induced factor homeobox 2-like, X-linked 0.986849
DEPDC7 DEP domain containing 7 0.984743
TCP11L1 t-complex 11, testis-specific-like 1 0.984743
CCDC73 coiled-coil domain containing 73 0.984743
SEPT12 septin 12 0.981794
TSPY3 testis specific protein, Y-linked 3 0.974642
TSPY10 testis specific protein, Y-linked 10 0.974642
SLC10A7 solute carrier family 10, member 7 0.974642
AKAP4 A kinase (PRKA) anchor protein 4 0.97044
ZMYND15 zinc finger, MYND-type containing 15 0.960797
QSER1 glutamine and serine rich 1 0.960378
SPATA3 spermatogenesis associated 3 0.954108
PRMT6 protein arginine methyltransferase 6 0.951187
CRISP1 cysteine-rich secretory protein 1 0.947852
HORMAD1 HORMA domain containing 1 0.942443
MSH5 mutS homolog 5 0.939119
TNP1 transition protein 1 (during histone to protamine replacement) 0.939119
TEX13A testis expressed 13A 0.931656
LRWD1 leucine-rich repeats and WD repeat domain containing 1 0.929173
SPAG11B sperm associated antigen 11B 0.928759
TEX101 testis expressed 101 0.927105
PGAM4 phosphoglycerate mutase family member 4 0.924626
STAG3 stromal antigen 3 0.921323
DEFB106A defensin, beta 106A 0.918436
CAPN11 calpain 11 0.918436
AMELY amelogenin, Y-linked 0.917199
KLHL10 kelch-like family member 10 0.902389
WBSCR28 Williams-Beuren syndrome chromosome region 28 0.900335
CSTF3 cleavage stimulation factor, 3' pre-RNA, subunit 3, 77kDa 0.900335
SPATA22 spermatogenesis associated 22 0.894589
SOX5 SRY (sex determining region Y)-box 5 0.88475
GAPDHS glyceraldehyde-3-phosphate dehydrogenase, spermatogenic 0.880243
WIPF3 WAS/WASL interacting protein family, member 3 0.875329
RGS22 regulator of G-protein signaling 22 0.861409
TAF7L TAF7-like RNA polymerase II, TATA box binding protein (TBP)-associated factor, 50kDa 0.857315
PIWIL4 piwi-like RNA-mediated gene silencing 4 0.856905
GTF2A1L general transcription factor IIA, 1-like 0.849945
LDHC lactate dehydrogenase C 0.844621
MND1 meiotic nuclear divisions 1 homolog (S. cerevisiae) 0.834788
TGIF2LY TGFB-induced factor homeobox 2-like, Y-linked 0.826589
EDDM3B epididymal protein 3B 0.826589
TDRD9 tudor domain containing 9 0.813052
LMTK2 lemur tyrosine kinase 2 0.811411
MOV10L1 Mov10 RISC complex RNA helicase like 1 0.805667
MEI1 meiosis inhibitor 1 0.803616
SPATA17 spermatogenesis associated 17 0.801154
PANK2 pantothenate kinase 2 0.798282
KDM5D lysine (K)-specific demethylase 5D 0.791721
ACR acrosin 0.77207
SYCP2 synaptonemal complex protein 2 0.767985
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae) 0.767167
CLDN11 claudin 11 0.763494
TSSK4 testis-specific serine kinase 4 0.763086
PUM2 pumilio RNA-binding family member 2 0.759824
RPS4Y1 ribosomal protein S4, Y-linked 1 0.759824
NLRP14 NLR family, pyrin domain containing 14 0.759824
TSSK2 testis-specific serine kinase 2 0.759416
TF transferrin 0.755749
SBF1 SET binding factor 1 0.752492
CREM cAMP responsive element modulator 0.751271
ACPP acid phosphatase, prostate 0.75005
GAS8 growth arrest-specific 8 0.746798
CDH18 cadherin 18, type 2 0.74436
KATNAL1 katanin p60 subunit A-like 1 0.742735
NXF2B nuclear RNA export factor 2B 0.740299
NXF2 nuclear RNA export factor 2 0.740299
TXNDC8 thioredoxin domain containing 8 (spermatozoa) 0.738676
PEX10 peroxisomal biogenesis factor 10 0.720461
SHFM1 split hand/foot malformation (ectrodactyly) type 1 0.709975
SPAG8 sperm associated antigen 8 0.706351
NR0B1 nuclear receptor subfamily 0, group B, member 1 0.705547
MSH4 mutS homolog 4 0.705547
AMELX amelogenin, X-linked 0.698715
UBQLN3 ubiquilin 3 0.697109
FKBP6 FK506 binding protein 6, 36kDa 0.697109
CECR2 cat eye syndrome chromosome region, candidate 2 0.693098
SNRNP70 small nuclear ribonucleoprotein 70kDa (U1) 0.690694
SOHLH1 spermatogenesis and oogenesis specific basic helix-loop-helix 1 0.689492
PRM3 protamine 3 0.689092
TXNDC2 thioredoxin domain containing 2 (spermatozoa) 0.684692
BRDT bromodomain, testis-specific 0.679499
FTHL17 ferritin, heavy polypeptide-like 17 0.67551
MLH3 mutL homolog 3 0.675112
MTHFR methylenetetrahydrofolate reductase (NAD(P)H) 0.674315
DEFB129 defensin, beta 129 0.67312
MTRR 5-methyltetrahydrofolate-homocysteine methyltransferase reductase 0.669538
HSPA2 heat shock 70kDa protein 2 0.66755
TEX11 testis expressed 11 0.662387
PIWIL2 piwi-like RNA-mediated gene silencing 2 0.661594
C6ORF10 chromosome 6 open reading frame 10 0.658422
INSL3 insulin-like 3 (Leydig cell) 0.654463
HSFX2 heat shock transcription factor family, X linked 2 0.651694
HSFX1 heat shock transcription factor family, X linked 1 0.651694
SPATA4 spermatogenesis associated 4 0.649323
PIWIL3 piwi-like RNA-mediated gene silencing 3 0.646953
ESX1 ESX homeobox 1 0.644586
CLDN10 claudin 10 0.62885
ART3 ADP-ribosyltransferase 3 0.61866
FKBPL FK506 binding protein like 0.616312
HORMAD2 HORMA domain containing 2 0.609666
KRT18 keratin 18, type I 0.609276
NOSTRIN nitric oxide synthase trafficking 0.607714
PARD6B par-6 family cell polarity regulator beta 0.606933
YBX2 Y box binding protein 2 0.606543
DEFB126 defensin, beta 126 0.595623
CCNA1 cyclin A1 0.594843
MAEL maelstrom spermatogenic transposon silencer 0.591727
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) 0.588612
PSMA3 proteasome (prosome, macropain) subunit, alpha type, 3 0.585108
CLK3 CDC-like kinase 3 0.582773
DAZAP1 DAZ associated protein 1 0.569163
PARP2 poly (ADP-ribose) polymerase 2 0.561004
DEFB106B defensin, beta 106B 0.557897
DNMT3L DNA (cytosine-5-)-methyltransferase 3-like 0.550134
NANOS2 nanos homolog 2 (Drosophila) 0.548971
AHRR aryl-hydrocarbon receptor repressor 0.537731
KCNK17 potassium channel, two pore domain subfamily K, member 17 0.537731
UBR2 ubiquitin protein ligase E3 component n-recognin 2 0.526904
SLC13A3 solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 3 0.521502
EIF3M eukaryotic translation initiation factor 3, subunit M 0.519575
DYNLT3 dynein, light chain, Tctex-type 3 0.51611
DMRT1 doublesex and mab-3 related transcription factor 1 0.513033
PRRG4 proline rich Gla (G-carboxyglutamic acid) 4 (transmembrane) 0.508424
PSMC3IP PSMC3 interacting protein 0.50459
FSHB follicle stimulating hormone, beta polypeptide 0.503441
RBMXL1 RNA binding motif protein, X-linked-like 1 0.503058
LPAR4 lysophosphatidic acid receptor 4 0.500379
ADCY10 adenylate cyclase 10 (soluble) 0.500379
INHA inhibin, alpha 0.499997
SRSF6 serine/arginine-rich splicing factor 6 0.498849
AMHR2 anti-Mullerian hormone receptor, type II 0.498467
SEPT14 septin 14 0.498085
NANOS3 nanos homolog 3 (Drosophila) 0.490835
MLH1 mutL homolog 1 0.490454
GNAO1 guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O 0.484744
PATZ1 POZ (BTB) and AT hook containing zinc finger 1 0.482084
CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1 0.480945
GSTTP1 glutathione S-transferase theta pseudogene 1 0.480566
GSTT1 glutathione S-transferase theta 1 0.480186
MAP1S microtubule-associated protein 1S 0.465794
RBMX RNA binding motif protein, X-linked 0.465794
CPEB1 cytoplasmic polyadenylation element binding protein 1 0.464283
SPTA1 spectrin, alpha, erythrocytic 1 0.459751
GGN gametogenetin 0.458619
HGS hepatocyte growth factor-regulated tyrosine kinase substrate 0.455978
DDX19B DEAD (Asp-Glu-Ala-Asp) box polypeptide 19B 0.453716
GNA13 guanine nucleotide binding protein (G protein), alpha 13 0.452962
SRSF4 serine/arginine-rich splicing factor 4 0.447687
GNA12 guanine nucleotide binding protein (G protein) alpha 12 0.437154
PIWIL1 piwi-like RNA-mediated gene silencing 1 0.436402
LHB luteinizing hormone beta polypeptide 0.431894
PCDH17 protocadherin 17 0.431894
KLK3 kallikrein-related peptidase 3 0.428891
ODF1 outer dense fiber of sperm tails 1 0.427765
SOX3 SRY (sex determining region Y)-box 3 0.415024
GART phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase 0.411657
ZNF165 zinc finger protein 165 0.407919
ESR2 estrogen receptor 2 (ER beta) 0.406798
AVEN apoptosis, caspase activation inhibitor 0.403064
SPO11 SPO11 meiotic protein covalently bound to DSB 0.398216
LBR lamin B receptor 0.396353
DNTT DNA nucleotidylexotransferase 0.394863
PYGO2 pygopus family PHD finger 2 0.393746
ALPPL2 alkaline phosphatase, placental-like 2 0.387794
SLC6A20 solute carrier family 6 (proline IMINO transporter), member 20 0.383337
SYCP1 synaptonemal complex protein 1 0.380739
HIPK3 homeodomain interacting protein kinase 3 0.37592
SRSF9 serine/arginine-rich splicing factor 9 0.373698
CENPV centromere protein V 0.371847
TUBA1C tubulin, alpha 1c 0.365932
KITLG KIT ligand 0.365932
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) 0.364454
ALPP alkaline phosphatase, placental 0.356341
ALPL alkaline phosphatase, liver/bone/kidney 0.355972
CCL14 chemokine (C-C motif) ligand 14 0.346042
GANC glucosidase, alpha; neutral C 0.34384
RACGAP1 Rac GTPase activating protein 1 0.343473
RBM5 RNA binding motif protein 5 0.340539
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.340173
PRLH prolactin releasing hormone 0.337608
TRPC3 transient receptor potential cation channel, subfamily C, member 3 0.324094
GSTM1 glutathione S-transferase mu 1 0.321545
TTBK2 tau tubulin kinase 2 0.321545
RAB27B RAB27B, member RAS oncogene family 0.317909
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein 0.317545
DDX3X DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked 0.315729
MTR 5-methyltetrahydrofolate-homocysteine methyltransferase 0.31464
PA2G4 proliferation-associated 2G4, 38kDa 0.31464
FOXI1 forkhead box I1 0.313915
SEPT5 septin 5 0.31029
GJA1 gap junction protein, alpha 1, 43kDa 0.308118
POLG polymerase (DNA directed), gamma 0.30342
AASS aminoadipate-semialdehyde synthase 0.297651
COX10 COX10 heme A:farnesyltransferase cytochrome c oxidase assembly factor 0.295492
CBX3 chromobox homolog 3 0.292975
PTER phosphotriesterase related 0.291539
ESR1 estrogen receptor 1 0.290821
CIRBP cold inducible RNA binding protein 0.28831
DNAH14 dynein, axonemal, heavy chain 14 0.286519
DNAH12 dynein, axonemal, heavy chain 12 0.286519
PIP prolactin-induced protein 0.28616
HNRNPL heterogeneous nuclear ribonucleoprotein L 0.280796
TAS2R38 taste receptor, type 2, member 38 0.279724
LHCGR luteinizing hormone/choriogonadotropin receptor 0.278654
OVGP1 oviductal glycoprotein 1, 120kDa 0.278297
MYLIP myosin regulatory light chain interacting protein 0.27794
IGF1 insulin-like growth factor 1 (somatomedin C) 0.27687
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma) 0.274376
ESPL1 extra spindle pole bodies homolog 1 (S. cerevisiae) 0.272597
HSF2 heat shock transcription factor 2 0.271886
PACRG PARK2 co-regulated 0.266913
SNRPN small nuclear ribonucleoprotein polypeptide N 0.266913
LIMK2 LIM domain kinase 2 0.261599
BRD3 bromodomain containing 3 0.260538
RBM3 RNA binding motif (RNP1, RRM) protein 3 0.258064
EIF4B eukaryotic translation initiation factor 4B 0.257711
CYP26B1 cytochrome P450, family 26, subfamily B, polypeptide 1 0.257358
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5 0.251015
DBT dihydrolipoamide branched chain transacylase E2 0.243645
POMC proopiomelanocortin 0.243295
SIRPA signal-regulatory protein alpha 0.241196
SECISBP2 SECIS binding protein 2 0.239799
HIST1H1B histone cluster 1, H1b 0.238752
CLDN2 claudin 2 0.23492
FASLG Fas ligand (TNF superfamily, member 6) 0.229716
DPP6 dipeptidyl-peptidase 6 0.223165
CLDN3 claudin 3 0.212608
CLDN8 claudin 8 0.212271
GAS6 growth arrest-specific 6 0.211934
TBPL1 TBP-like 1 0.207245
RXFP2 relaxin/insulin-like family peptide receptor 2 0.20658
NR5A1 nuclear receptor subfamily 5, group A, member 1 0.205254
GYPE glycophorin E (MNS blood group) 0.203933
DDX20 DEAD (Asp-Glu-Ala-Asp) box polypeptide 20 0.203604
DDX47 DEAD (Asp-Glu-Ala-Asp) box polypeptide 47 0.200331
TKTL1 transketolase-like 1 0.199356
ATP6AP1 ATPase, H+ transporting, lysosomal accessory protein 1 0.193915
GLA galactosidase, alpha 0.192344
JAM3 junctional adhesion molecule 3 0.188938
PCDH10 protocadherin 10 0.183835
SMCP sperm mitochondria-associated cysteine-rich protein 0.183541
NRIP1 nuclear receptor interacting protein 1 0.182086
LIPE lipase, hormone-sensitive 0.177029
TSC22D3 TSC22 domain family, member 3 0.175947
CYP19A1 cytochrome P450, family 19, subfamily A, polypeptide 1 0.175411
TMEM245 transmembrane protein 245 0.171785
HSD17B3 hydroxysteroid (17-beta) dehydrogenase 3 0.171286
CYP21A2 cytochrome P450, family 21, subfamily A, polypeptide 2 0.170789
METTL13 methyltransferase like 13 0.166768
HLA-DPB1 major histocompatibility complex, class II, DP beta 1 0.165435
MTM1 myotubularin 1 0.164571
KDM5C lysine (K)-specific demethylase 5C 0.162908
TERT telomerase reverse transcriptase 0.162505
XRCC1 X-ray repair complementing defective repair in Chinese hamster cells 1 0.161716
NDUFA5 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 5 0.161523
ANOS1 anosmin 1 0.161139
DNAH9 dynein, axonemal, heavy chain 9 0.160761
SNRPA small nuclear ribonucleoprotein polypeptide A 0.159838
FST follistatin 0.159838
MNX1 motor neuron and pancreas homeobox 1 0.159124
CLCN2 chloride channel, voltage-sensitive 2 0.158778