azurophil granule lumen Gene Set

Dataset GO Cellular Component Annotations 2025
Category structural or functional annotations
Type cellular component
Description The volume enclosed by the membrane of an azurophil granule, a primary lysosomal granule found in neutrophil granulocytes that contains a wide range of hydrolytic enzymes and is released into the extracellular fluid. (Gene Ontology, GO_0035578)
External Link http://amigo.geneontology.org/amigo/term/GO:0035578
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Genes

90 proteins localized to the azurophil granule lumen cellular component from the curated GO Cellular Component Annotations 2025 dataset.

Symbol Name
ACLY ATP citrate lyase
ACTR10 actin-related protein 10 homolog (S. cerevisiae)
ACTR2 ARP2 actin-related protein 2 homolog (yeast)
ADA2 adenosine deaminase 2
AGA aspartylglucosaminidase
ANKRD44 ankyrin repeat domain 44
ANXA2 annexin A2
ARHGAP45 Rho GTPase activating protein 45
ARSA arylsulfatase A
AZU1 azurocidin 1
BPI bactericidal/permeability-increasing protein
C3 complement component 3
C6ORF120 chromosome 6 open reading frame 120
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast)
CCT2 chaperonin containing TCP1, subunit 2 (beta)
CCT8 chaperonin containing TCP1, subunit 8 (theta)
CPPED1 calcineurin-like phosphoesterase domain containing 1
CREG1 cellular repressor of E1A-stimulated genes 1
CTSA cathepsin A
CTSC cathepsin C
CTSG cathepsin G
CYB5R3 cytochrome b5 reductase 3
DEFA1 defensin, alpha 1
DEFA3 defensin, alpha 3, neutrophil-specific
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3
DPP7 dipeptidyl-peptidase 7
DSN1 DSN1, MIS12 kinetochore complex component
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1
ELANE elastase, neutrophil expressed
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAF2 Fas associated factor family member 2
FRK fyn-related Src family tyrosine kinase
FTL ferritin, light polypeptide
FUCA1 fucosidase, alpha-L- 1, tissue
FUCA2 fucosidase, alpha-L- 2, plasma
GALNS galactosamine (N-acetyl)-6-sulfatase
GCA grancalcin, EF-hand calcium binding protein
GDI2 GDP dissociation inhibitor 2
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
GLB1 galactosidase, beta 1
GM2A GM2 ganglioside activator
GNS glucosamine (N-acetyl)-6-sulfatase
GRN granulin
GUSB glucuronidase, beta
HEBP2 heme binding protein 2
HEXB hexosaminidase B (beta polypeptide)
HRNR hornerin
IMPDH1 IMP (inosine 5'-monophosphate) dehydrogenase 1
IST1 increased sodium tolerance 1 homolog (yeast)
LYZ lysozyme
MAN2B1 mannosidase, alpha, class 2B, member 1
MAPK1 mitogen-activated protein kinase 1
MNDA myeloid cell nuclear differentiation antigen
MPO myeloperoxidase
NAPRT nicotinate phosphoribosyltransferase
NAT8 N-acetyltransferase 8 (GCN5-related, putative)
NHLRC3 NHL repeat containing 3
NPC2 Niemann-Pick disease, type C2
ORM2 orosomucoid 2
PA2G4 proliferation-associated 2G4, 38kDa
PADI2 peptidyl arginine deiminase, type II
PLAC8 placenta-specific 8
PRDX5 peroxiredoxin 5
PRKCD protein kinase C, delta
PRSS2 protease, serine, 2 (trypsin 2)
PRSS57 protease, serine, 57
PRTN3 proteinase 3
PSMD1 proteasome (prosome, macropain) 26S subunit, non-ATPase, 1
PTGES2 prostaglandin E synthase 2
PYCARD PYD and CARD domain containing
PYGB phosphorylase, glycogen; brain
RETN resistin
RNASE2 ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin)
RNASE3 ribonuclease, RNase A family, 3
RNASET2 ribonuclease T2
S100A7 S100 calcium binding protein A7
SDCBP syndecan binding protein (syntenin)
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3
STK11IP serine/threonine kinase 11 interacting protein
TINAGL1 tubulointerstitial nephritis antigen-like 1
TOLLIP toll interacting protein
TRAPPC1 trafficking protein particle complex 1
TTR transthyretin
TUBB tubulin, beta class I
TUBB4B tubulin, beta 4B class IVb
TXNDC5 thioredoxin domain containing 5 (endoplasmic reticulum)
UNC13D unc-13 homolog D (C. elegans)
VAT1 vesicle amine transport 1
VCP valosin containing protein