azurophil granule Gene Set

Dataset GO Cellular Component Annotations 2025
Category structural or functional annotations
Type cellular component
Description Primary lysosomal granule found in neutrophil granulocytes. Contains a wide range of hydrolytic enzymes and is released into the extracellular fluid. (Gene Ontology, GO_0042582)
External Link http://amigo.geneontology.org/amigo/term/GO:0042582
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Genes

156 proteins localized to the azurophil granule cellular component from the curated GO Cellular Component Annotations 2025 dataset.

Symbol Name
ABCA13 ATP-binding cassette, sub-family A (ABC1), member 13
ACLY ATP citrate lyase
ACP3 acid phosphatase 3
ACTR10 actin-related protein 10 homolog (S. cerevisiae)
ACTR2 ARP2 actin-related protein 2 homolog (yeast)
ADA2 adenosine deaminase 2
AGA aspartylglucosaminidase
ANKRD44 ankyrin repeat domain 44
ANXA11 annexin A11
ANXA2 annexin A2
ARHGAP45 Rho GTPase activating protein 45
ARL8A ADP-ribosylation factor-like 8A
ARSA arylsulfatase A
ATP11B ATPase, class VI, type 11B
ATP6V0C ATPase, H+ transporting, lysosomal 16kDa, V0 subunit c
ATP8A1 ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1
AZU1 azurocidin 1
B4GALT1 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1
BPI bactericidal/permeability-increasing protein
BST2 bone marrow stromal cell antigen 2
C3 complement component 3
C3AR1 complement component 3a receptor 1
C6ORF120 chromosome 6 open reading frame 120
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast)
CCT2 chaperonin containing TCP1, subunit 2 (beta)
CCT8 chaperonin containing TCP1, subunit 8 (theta)
CD63 CD63 molecule
CD68 CD68 molecule
CDC50A cell division cycle 50 P4-ATPase accessory subunit A
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CEACAM8 carcinoembryonic antigen-related cell adhesion molecule 8
CKAP4 cytoskeleton-associated protein 4
CMTM6 CKLF-like MARVEL transmembrane domain containing 6
CPNE1 copine I
CPNE3 copine III
CPPED1 calcineurin-like phosphoesterase domain containing 1
CREG1 cellular repressor of E1A-stimulated genes 1
CTSA cathepsin A
CTSC cathepsin C
CTSG cathepsin G
CYB5R3 cytochrome b5 reductase 3
DDOST dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit (non-catalytic)
DEFA1 defensin, alpha 1
DEFA3 defensin, alpha 3, neutrophil-specific
DEFA4 defensin, alpha 4, corticostatin
DNAJC13 DnaJ (Hsp40) homolog, subfamily C, member 13
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5
DPP7 dipeptidyl-peptidase 7
DSN1 DSN1, MIS12 kinetochore complex component
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1
ELANE elastase, neutrophil expressed
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAF2 Fas associated factor family member 2
FPR1 formyl peptide receptor 1
FRK fyn-related Src family tyrosine kinase
FTL ferritin, light polypeptide
FUCA1 fucosidase, alpha-L- 1, tissue
FUCA2 fucosidase, alpha-L- 2, plasma
GAA glucosidase, alpha; acid
GALNS galactosamine (N-acetyl)-6-sulfatase
GCA grancalcin, EF-hand calcium binding protein
GDI2 GDP dissociation inhibitor 2
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
GLB1 galactosidase, beta 1
GLIPR1 GLI pathogenesis-related 1
GM2A GM2 ganglioside activator
GNS glucosamine (N-acetyl)-6-sulfatase
GRN granulin
GUSB glucuronidase, beta
HEBP2 heme binding protein 2
HEXA hexosaminidase A (alpha polypeptide)
HEXB hexosaminidase B (beta polypeptide)
HFE hemochromatosis
HRNR hornerin
IMPDH1 IMP (inosine 5'-monophosphate) dehydrogenase 1
IRAG2 inositol 1,4,5-triphosphate receptor associated 2
IST1 increased sodium tolerance 1 homolog (yeast)
ITM2C integral membrane protein 2C
LAMP1 lysosomal-associated membrane protein 1
LAMP2 lysosomal-associated membrane protein 2
LAMTOR1 late endosomal/lysosomal adaptor, MAPK and MTOR activator 1
LPCAT1 lysophosphatidylcholine acyltransferase 1
LYZ lysozyme
MAGT1 magnesium transporter 1
MAN2B1 mannosidase, alpha, class 2B, member 1
MANBA mannosidase, beta A, lysosomal
MAPK1 mitogen-activated protein kinase 1
MGST1 microsomal glutathione S-transferase 1
MNDA myeloid cell nuclear differentiation antigen
MPO myeloperoxidase
NAPRT nicotinate phosphoribosyltransferase
NAT8 N-acetyltransferase 8 (GCN5-related, putative)
NCSTN nicastrin
NDUFC2 NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 2, 14.5kDa
NFAM1 NFAT activating protein with ITAM motif 1
NHLRC3 NHL repeat containing 3
NPC2 Niemann-Pick disease, type C2
OLFM4 olfactomedin 4
ORM2 orosomucoid 2
PA2G4 proliferation-associated 2G4, 38kDa
PADI2 peptidyl arginine deiminase, type II
PIGR polymeric immunoglobulin receptor
PLAC8 placenta-specific 8
PRCP prolylcarboxypeptidase (angiotensinase C)
PRDX5 peroxiredoxin 5
PRKCD protein kinase C, delta
PRSS2 protease, serine, 2 (trypsin 2)
PRSS57 protease, serine, 57
PRTN3 proteinase 3
PSEN1 presenilin 1
PSMD1 proteasome (prosome, macropain) 26S subunit, non-ATPase, 1
PTGES2 prostaglandin E synthase 2
PYCARD PYD and CARD domain containing
PYGB phosphorylase, glycogen; brain
RAB37 RAB37, member RAS oncogene family
RAB3D RAB3D, member RAS oncogene family
RAB44 RAB44, member RAS oncogene family
RAB5C RAB5C, member RAS oncogene family
RAP1B RAP1B, member of RAS oncogene family
RETN resistin
RNASE2 ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin)
RNASE3 ribonuclease, RNase A family, 3
RNASET2 ribonuclease T2
S100A7 S100 calcium binding protein A7
SDCBP syndecan binding protein (syntenin)
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3
SFTPA2 surfactant protein A2
SLCO4C1 solute carrier organic anion transporter family, member 4C1
SNAP23 synaptosomal-associated protein, 23kDa
SNAP29 synaptosomal-associated protein, 29kDa
STK11IP serine/threonine kinase 11 interacting protein
STOM stomatin
STX3 syntaxin 3
STX7 syntaxin 7
STXBP2 syntaxin binding protein 2
SURF4 surfeit 4
SYNGR1 synaptogyrin 1
TINAGL1 tubulointerstitial nephritis antigen-like 1
TMEM179B transmembrane protein 179B
TOLLIP toll interacting protein
TOM1 target of myb1 (chicken)
TRAPPC1 trafficking protein particle complex 1
TTR transthyretin
TUBB tubulin, beta class I
TUBB4B tubulin, beta 4B class IVb
TXNDC5 thioredoxin domain containing 5 (endoplasmic reticulum)
UNC13D unc-13 homolog D (C. elegans)
VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1)
VAMP7 vesicle-associated membrane protein 7
VAMP8 vesicle-associated membrane protein 8
VAPA VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa
VAT1 vesicle amine transport 1
VCP valosin containing protein
VNN1 vanin 1