baclofen-1536 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

196 genes differentially expressed following the baclofen-1536 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
A1CF APOBEC1 complementation factor
ABHD2 abhydrolase domain containing 2
ADPRM ADP-ribose/CDP-alcohol diphosphatase, manganese-dependent
ADTRP androgen-dependent TFPI-regulating protein
AHNAK2 AHNAK nucleoprotein 2
AKAP8L A kinase (PRKA) anchor protein 8-like
ANKRD12 ankyrin repeat domain 12
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited)
ARHGAP33 Rho GTPase activating protein 33
ARHGAP4 Rho GTPase activating protein 4
ARHGEF17 Rho guanine nucleotide exchange factor (GEF) 17
ARHGEF28 Rho guanine nucleotide exchange factor (GEF) 28
BHLHE41 basic helix-loop-helix family, member e41
C9ORF156 chromosome 9 open reading frame 156
CA9 carbonic anhydrase IX
CACNA1H calcium channel, voltage-dependent, T type, alpha 1H subunit
CACNA2D2 calcium channel, voltage-dependent, alpha 2/delta subunit 2
CD200 CD200 molecule
CEP41 centrosomal protein 41kDa
COL17A1 collagen, type XVII, alpha 1
COL1A1 collagen, type I, alpha 1
DDX3X DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked
DEAF1 DEAF1 transcription factor
DEPDC5 DEP domain containing 5
DGCR2 DiGeorge syndrome critical region gene 2
DNAJB12 DnaJ (Hsp40) homolog, subfamily B, member 12
DNAJC4 DnaJ (Hsp40) homolog, subfamily C, member 4
DNPEP aspartyl aminopeptidase
DPF1 D4, zinc and double PHD fingers family 1
DTX2 deltex 2, E3 ubiquitin ligase
DVL3 dishevelled segment polarity protein 3
EHMT1 euchromatic histone-lysine N-methyltransferase 1
EMID1 EMI domain containing 1
FBXO9 F-box protein 9
GPR137 G protein-coupled receptor 137
HCRP1 hepatocellular carcinoma-related HCRP1
HDAC4 histone deacetylase 4
HOMER3 homer scaffolding protein 3
IFIT5 interferon-induced protein with tetratricopeptide repeats 5
IRS2 insulin receptor substrate 2
JAG1 jagged 1
KCNJ5 potassium channel, inwardly rectifying subfamily J, member 5
KIR3DX1 killer cell immunoglobulin-like receptor, three domains, X1
KLF15 Kruppel-like factor 15
LMAN1 lectin, mannose-binding, 1
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1
METTL16 methyltransferase like 16
MPPE1 metallophosphoesterase 1
MTA1 metastasis associated 1
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric
MYL4 myosin, light chain 4, alkali; atrial, embryonic
MYO1F myosin IF
NBEAL2 neurobeachin-like 2
NEK9 NIMA-related kinase 9
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NRSN2 neurensin 2
NUDT18 nudix (nucleoside diphosphate linked moiety X)-type motif 18
NUDT4 nudix (nucleoside diphosphate linked moiety X)-type motif 4
ORAI2 ORAI calcium release-activated calcium modulator 2
OSGIN2 oxidative stress induced growth inhibitor family member 2
PBX2 pre-B-cell leukemia homeobox 2
PDK2 pyruvate dehydrogenase kinase, isozyme 2
PLA2G4C phospholipase A2, group IVC (cytosolic, calcium-independent)
PML promyelocytic leukemia
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
RAB6B RAB6B, member RAS oncogene family
RALGPS2 Ral GEF with PH domain and SH3 binding motif 2
RGS2 regulator of G-protein signaling 2
RNF126P1 ring finger protein 126 pseudogene 1
RWDD3 RWD domain containing 3
SDC2 syndecan 2
SEC24A SEC24 family member A
SEMA6D sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D
SIGLEC15 sialic acid binding Ig-like lectin 15
SIK2 salt-inducible kinase 2
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37
SLC4A8 solute carrier family 4, sodium bicarbonate cotransporter, member 8
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLN sarcolipin
SMC1A structural maintenance of chromosomes 1A
SORT1 sortilin 1
SOX15 SRY (sex determining region Y)-box 15
SPG20 spastic paraplegia 20 (Troyer syndrome)
SPOCK2 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2
SPTBN1 spectrin, beta, non-erythrocytic 1
SRD5A3 steroid 5 alpha-reductase 3
SYNJ2 synaptojanin 2
TAF9B TAF9B RNA polymerase II, TATA box binding protein (TBP)-associated factor, 31kDa
TBC1D19 TBC1 domain family, member 19
TBC1D2 TBC1 domain family, member 2
TIMELESS timeless circadian clock
TLN1 talin 1
TMEM184C transmembrane protein 184C
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TRD T cell receptor delta locus
TRIB2 tribbles pseudokinase 2
TTLL5 tubulin tyrosine ligase-like family member 5
USP48 ubiquitin specific peptidase 48
VAC14 Vac14 homolog (S. cerevisiae)
ZNF675 zinc finger protein 675

decreased expression

Symbol Name
ACADS acyl-CoA dehydrogenase, C-2 to C-3 short chain
ACYP2 acylphosphatase 2, muscle type
ALPK1 alpha-kinase 1
ANKRD2 ankyrin repeat domain 2 (stretch responsive muscle)
ANKZF1 ankyrin repeat and zinc finger domain containing 1
APLP1 amyloid beta (A4) precursor-like protein 1
ARRB1 arrestin, beta 1
ART1 ADP-ribosyltransferase 1
ATHL1 ATH1, acid trehalase-like 1 (yeast)
C1ORF105 chromosome 1 open reading frame 105
C22ORF29 chromosome 22 open reading frame 29
C3 complement component 3
C6ORF47 chromosome 6 open reading frame 47
CAMKMT calmodulin-lysine N-methyltransferase
CCNT1 cyclin T1
CGA glycoprotein hormones, alpha polypeptide
CHST7 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 7
CIDEC cell death-inducing DFFA-like effector c
CNNM1 cyclin and CBS domain divalent metal cation transport mediator 1
CTDP1 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1
CUEDC1 CUE domain containing 1
CYP20A1 cytochrome P450, family 20, subfamily A, polypeptide 1
DAPP1 dual adaptor of phosphotyrosine and 3-phosphoinositides
ENO3 enolase 3 (beta, muscle)
FBRS fibrosin
FLRT3 fibronectin leucine rich transmembrane protein 3
FMOD fibromodulin
FURIN furin (paired basic amino acid cleaving enzyme)
GAMT guanidinoacetate N-methyltransferase
GLS2 glutaminase 2 (liver, mitochondrial)
GMPR guanosine monophosphate reductase
GRPR gastrin-releasing peptide receptor
HEY2 hes-related family bHLH transcription factor with YRPW motif 2
HIRA histone cell cycle regulator
HIST1H2AJ histone cluster 1, H2aj
HIST1H2BJ histone cluster 1, H2bj
HMOX1 heme oxygenase 1
IL17RA interleukin 17 receptor A
INPP5E inositol polyphosphate-5-phosphatase, 72 kDa
KAT2A K(lysine) acetyltransferase 2A
LINC00339 long intergenic non-protein coding RNA 339
LRCH1 leucine-rich repeats and calponin homology (CH) domain containing 1
LSM14B LSM14B, SCD6 homolog B (S. cerevisiae)
LTBP2 latent transforming growth factor beta binding protein 2
LZTFL1 leucine zipper transcription factor-like 1
LZTS3 leucine zipper, putative tumor suppressor family member 3
MAPKBP1 mitogen-activated protein kinase binding protein 1
MMP2 matrix metallopeptidase 2
MSI1 musashi RNA-binding protein 1
MXD3 MAX dimerization protein 3
NACA2 nascent polypeptide-associated complex alpha subunit 2
NAT6 N-acetyltransferase 6 (GCN5-related)
NIPAL2 NIPA-like domain containing 2
NKX3-2 NK3 homeobox 2
NLRX1 NLR family member X1
NPFFR1 neuropeptide FF receptor 1
OR2F1 olfactory receptor, family 2, subfamily F, member 1 (gene/pseudogene)
OSMR oncostatin M receptor
OXTR oxytocin receptor
P2RY6 pyrimidinergic receptor P2Y, G-protein coupled, 6
PDPR pyruvate dehydrogenase phosphatase regulatory subunit
PLEKHG6 pleckstrin homology domain containing, family G (with RhoGef domain) member 6
PMM1 phosphomannomutase 1
PPP1R14D protein phosphatase 1, regulatory (inhibitor) subunit 14D
PPT2 palmitoyl-protein thioesterase 2
RAB30 RAB30, member RAS oncogene family
RIBC2 RIB43A domain with coiled-coils 2
RIN2 Ras and Rab interactor 2
ROM1 retinal outer segment membrane protein 1
RPH3AL rabphilin 3A-like (without C2 domains)
RRNAD1 ribosomal RNA adenine dimethylase domain containing 1
SAYSD1 SAYSVFN motif domain containing 1
SCGB2A2 secretoglobin, family 2A, member 2
SDC3 syndecan 3
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1
SLC9A5 solute carrier family 9, subfamily A (NHE5, cation proton antiporter 5), member 5
STRA6 stimulated by retinoic acid 6
SULT4A1 sulfotransferase family 4A, member 1
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa
TCTN2 tectonic family member 2
THBS3 thrombospondin 3
TICAM1 toll-like receptor adaptor molecule 1
TMC5 transmembrane channel-like 5
TMCC2 transmembrane and coiled-coil domain family 2
TMEM104 transmembrane protein 104
TNRC6B trinucleotide repeat containing 6B
TRAIP TRAF interacting protein
TUT1 terminal uridylyl transferase 1, U6 snRNA-specific
UNC93B1 unc-93 homolog B1 (C. elegans)
UPP1 uridine phosphorylase 1
WDR62 WD repeat domain 62
XRCC3 X-ray repair complementing defective repair in Chinese hamster cells 3
YY2 YY2 transcription factor
ZNF329 zinc finger protein 329
ZNF76 zinc finger protein 76
ZSCAN31 zinc finger and SCAN domain containing 31