baclofen-5414 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

200 genes differentially expressed following the baclofen-5414 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCA7 ATP-binding cassette, sub-family A (ABC1), member 7
ALDH1L1 aldehyde dehydrogenase 1 family, member L1
AOC2 amine oxidase, copper containing 2 (retina-specific)
APOBEC3C apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3C
ATXN2L ataxin 2-like
B3GNT4 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 4
BHLHE40 basic helix-loop-helix family, member e40
BRD7P3 bromodomain containing 7 pseudogene 3
BRF1 BRF1, RNA polymerase III transcription initiation factor 90 kDa subunit
C5ORF42 chromosome 5 open reading frame 42
CACNA1I calcium channel, voltage-dependent, T type, alpha 1I subunit
CBFA2T2 core-binding factor, runt domain, alpha subunit 2; translocated to, 2
CCDC71 coiled-coil domain containing 71
CCL21 chemokine (C-C motif) ligand 21
CDC42 cell division cycle 42
CFAP45 cilia and flagella associated protein 45
CFLAR CASP8 and FADD-like apoptosis regulator
CGA glycoprotein hormones, alpha polypeptide
CLCN7 chloride channel, voltage-sensitive 7
COL1A1 collagen, type I, alpha 1
COL6A1 collagen, type VI, alpha 1
CORO7 coronin 7
CREBZF CREB/ATF bZIP transcription factor
CYR61 cysteine-rich, angiogenic inducer, 61
DAPK2 death-associated protein kinase 2
DST dystonin
DTNA dystrobrevin, alpha
EDA ectodysplasin A
EDNRA endothelin receptor type A
EHD2 EH-domain containing 2
EML2 echinoderm microtubule associated protein like 2
ENTPD3 ectonucleoside triphosphate diphosphohydrolase 3
EPS15L1 epidermal growth factor receptor pathway substrate 15-like 1
FAM105A family with sequence similarity 105, member A
FCGBP Fc fragment of IgG binding protein
FGF2 fibroblast growth factor 2 (basic)
FPR1 formyl peptide receptor 1
FRMD4A FERM domain containing 4A
FSCN1 fascin actin-bundling protein 1
FUT6 fucosyltransferase 6 (alpha (1,3) fucosyltransferase)
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
GK glycerol kinase
GLUD2 glutamate dehydrogenase 2
GLYR1 glyoxylate reductase 1 homolog (Arabidopsis)
GM2A GM2 ganglioside activator
GPR21 G protein-coupled receptor 21
HAMP hepcidin antimicrobial peptide
HRASLS2 HRAS-like suppressor 2
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IL9R interleukin 9 receptor
KCNN1 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 1
KIF1C kinesin family member 1C
LDLRAD4 low density lipoprotein receptor class A domain containing 4
LILRB2 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2
LIN7B lin-7 homolog B (C. elegans)
LINC00260 long intergenic non-protein coding RNA 260
MAN1A2 mannosidase, alpha, class 1A, member 2
MAN1C1 mannosidase, alpha, class 1C, member 1
MC5R melanocortin 5 receptor
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MECOM MDS1 and EVI1 complex locus
METTL16 methyltransferase like 16
MKL1 megakaryoblastic leukemia (translocation) 1
MMP24 matrix metallopeptidase 24 (membrane-inserted)
NCAM1 neural cell adhesion molecule 1
NFATC1 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
NMT1 N-myristoyltransferase 1
NPFF neuropeptide FF-amide peptide precursor
NR6A1 nuclear receptor subfamily 6, group A, member 1
OGFR opioid growth factor receptor
OR2B6 olfactory receptor, family 2, subfamily B, member 6
PCLO piccolo presynaptic cytomatrix protein
PDE3B phosphodiesterase 3B, cGMP-inhibited
POFUT1 protein O-fucosyltransferase 1
PPP3R1 protein phosphatase 3, regulatory subunit B, alpha
PPP5C protein phosphatase 5, catalytic subunit
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8
RB1 retinoblastoma 1
RPS6KA6 ribosomal protein S6 kinase, 90kDa, polypeptide 6
RUNX1 runt-related transcription factor 1
RUNX2 runt-related transcription factor 2
SAG S-antigen; retina and pineal gland (arrestin)
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin)
SHOX2 short stature homeobox 2
SKI SKI proto-oncogene
SLC25A21 solute carrier family 25 (mitochondrial oxoadipate carrier), member 21
SORBS3 sorbin and SH3 domain containing 3
SPTBN1 spectrin, beta, non-erythrocytic 1
STX7 syntaxin 7
TAS2R10 taste receptor, type 2, member 10
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
THNSL2 threonine synthase-like 2 (S. cerevisiae)
TICAM1 toll-like receptor adaptor molecule 1
TNFRSF8 tumor necrosis factor receptor superfamily, member 8
TRBC1 T cell receptor beta constant 1
TSPAN9 tetraspanin 9
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
WNK1 WNK lysine deficient protein kinase 1
XDH xanthine dehydrogenase
ZNF253 zinc finger protein 253

decreased expression

Symbol Name
ACTL8 actin-like 8
ADAP2 ArfGAP with dual PH domains 2
AKR1C2 aldo-keto reductase family 1, member C2
ALKBH4 alkB, alkylation repair homolog 4 (E. coli)
ATAD5 ATPase family, AAA domain containing 5
C14ORF93 chromosome 14 open reading frame 93
C1ORF159 chromosome 1 open reading frame 159
C5ORF45 chromosome 5 open reading frame 45
C7ORF43 chromosome 7 open reading frame 43
CAMK1 calcium/calmodulin-dependent protein kinase I
CAPN5 calpain 5
CD82 CD82 molecule
CD8A CD8a molecule
CHKB choline kinase beta
CLIC2 chloride intracellular channel 2
CLSTN2 calsyntenin 2
CORO2A coronin, actin binding protein, 2A
CPPED1 calcineurin-like phosphoesterase domain containing 1
CUZD1 CUB and zona pellucida-like domains 1
CXADR coxsackie virus and adenovirus receptor
CYP4F11 cytochrome P450, family 4, subfamily F, polypeptide 11
DHRS3 dehydrogenase/reductase (SDR family) member 3
DUSP13 dual specificity phosphatase 13
ENO2 enolase 2 (gamma, neuronal)
ETAA1 Ewing tumor-associated antigen 1
FAM204A family with sequence similarity 204, member A
FLCN folliculin
GMPR guanosine monophosphate reductase
GNG7 guanine nucleotide binding protein (G protein), gamma 7
GTF3C5 general transcription factor IIIC, polypeptide 5, 63kDa
HIST1H2BJ histone cluster 1, H2bj
HIST1H3B histone cluster 1, H3b
HOXC5 homeobox C5
IFI27 interferon, alpha-inducible protein 27
IFT54 intraflagellar transport 54
INF2 inverted formin, FH2 and WH2 domain containing
INO80D INO80 complex subunit D
INPP1 inositol polyphosphate-1-phosphatase
IQCG IQ motif containing G
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
KIF13A kinesin family member 13A
LARP6 La ribonucleoprotein domain family, member 6
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase
MBIP MAP3K12 binding inhibitory protein 1
MCOLN1 mucolipin 1
MFAP2 microfibrillar-associated protein 2
MMP9 matrix metallopeptidase 9
MTERF4 mitochondrial transcription termination factor 4
NAT6 N-acetyltransferase 6 (GCN5-related)
NEK11 NIMA-related kinase 11
NLRX1 NLR family member X1
NPIPB3 nuclear pore complex interacting protein family, member B3
OLFML2A olfactomedin-like 2A
OXTR oxytocin receptor
PAOX polyamine oxidase (exo-N4-amino)
PCYOX1L prenylcysteine oxidase 1 like
PIGZ phosphatidylinositol glycan anchor biosynthesis, class Z
PIM1 Pim-1 proto-oncogene, serine/threonine kinase
PIM2 Pim-2 proto-oncogene, serine/threonine kinase
PITX2 paired-like homeodomain 2
PLD3 phospholipase D family, member 3
PLEK2 pleckstrin 2
PRSS22 protease, serine, 22
QPCT glutaminyl-peptide cyclotransferase
RAB3A RAB3A, member RAS oncogene family
RFTN1 raftlin, lipid raft linker 1
RHPN1-AS1 RHPN1 antisense RNA 1 (head to head)
RPAP1 RNA polymerase II associated protein 1
RPL23AP32 ribosomal protein L23a pseudogene 32
SCAI suppressor of cancer cell invasion
SEMA4A sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SLC12A5 solute carrier family 12 (potassium/chloride transporter), member 5
SLC41A3 solute carrier family 41, member 3
SLC44A1 solute carrier family 44 (choline transporter), member 1
SLC9A3R2 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 2
SLIT2 slit homolog 2 (Drosophila)
SPAG4 sperm associated antigen 4
TAGLN transgelin
TCEB3B transcription elongation factor B polypeptide 3B (elongin A2)
TCTN2 tectonic family member 2
TGFB1I1 transforming growth factor beta 1 induced transcript 1
TIMM50 translocase of inner mitochondrial membrane 50 homolog (S. cerevisiae)
TM6SF1 transmembrane 6 superfamily member 1
TMEM212 transmembrane protein 212
TMEM45A transmembrane protein 45A
TNFRSF11A tumor necrosis factor receptor superfamily, member 11a, NFKB activator
TRABD TraB domain containing
TRPV6 transient receptor potential cation channel, subfamily V, member 6
TTC30A tetratricopeptide repeat domain 30A
USB1 U6 snRNA biogenesis 1
VEGFB vascular endothelial growth factor B
VGF VGF nerve growth factor inducible
VIPR1 vasoactive intestinal peptide receptor 1
WDR25 WD repeat domain 25
XAB2 XPA binding protein 2
ZBTB48 zinc finger and BTB domain containing 48
ZNF551 zinc finger protein 551
ZNF639 zinc finger protein 639
ZNF862 zinc finger protein 862