baclofen-6313 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

198 genes differentially expressed following the baclofen-6313 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCC6 ATP-binding cassette, sub-family C (CFTR/MRP), member 6
ABHD2 abhydrolase domain containing 2
ACSM3 acyl-CoA synthetase medium-chain family member 3
ALDH6A1 aldehyde dehydrogenase 6 family, member A1
ARHGEF11 Rho guanine nucleotide exchange factor (GEF) 11
ATN1 atrophin 1
BCL2 B-cell CLL/lymphoma 2
BRF2 BRF2, RNA polymerase III transcription initiation factor 50 kDa subunit
BTF3P11 basic transcription factor 3 pseudogene 11
C14ORF105 chromosome 14 open reading frame 105
CACNA1G calcium channel, voltage-dependent, T type, alpha 1G subunit
CD52 CD52 molecule
CD79B CD79b molecule, immunoglobulin-associated beta
CDH8 cadherin 8, type 2
CIDEB cell death-inducing DFFA-like effector b
CLEC11A C-type lectin domain family 11, member A
CLUHP3 clustered mitochondria (cluA/CLU1) homolog pseudogene 3
COL10A1 collagen, type X, alpha 1
CTNS cystinosin, lysosomal cystine transporter
DCTN1 dynactin 1
EFNA3 ephrin-A3
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2
ERC1 ELKS/RAB6-interacting/CAST family member 1
ESR1 estrogen receptor 1
EXOSC1 exosome component 1
FRMPD1 FERM and PDZ domain containing 1
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
GABRR2 gamma-aminobutyric acid (GABA) A receptor, rho 2
GLRX3 glutaredoxin 3
GPRC5D G protein-coupled receptor, class C, group 5, member D
HABP4 hyaluronan binding protein 4
HIST1H4D histone cluster 1, H4d
HMG20B high mobility group 20B
INO80B INO80 complex subunit B
IRF4 interferon regulatory factor 4
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
KCNAB1 potassium channel, voltage gated subfamily A regulatory beta subunit 1
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KCNV1 potassium channel, voltage gated modifier subfamily V, member 1
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1
KIAA1456 KIAA1456
KIF1A kinesin family member 1A
KIR2DS1 killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 1
KLHL4 kelch-like family member 4
KYNU kynureninase
LAMB4 laminin, beta 4
LDLRAD4 low density lipoprotein receptor class A domain containing 4
LLPH LLP homolog, long-term synaptic facilitation (Aplysia)
LOXL3 lysyl oxidase-like 3
LRCH4 leucine-rich repeats and calponin homology (CH) domain containing 4
LRP2 low density lipoprotein receptor-related protein 2
LY6D lymphocyte antigen 6 complex, locus D
MAL mal, T-cell differentiation protein
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2
MAPRE2 microtubule-associated protein, RP/EB family, member 2
METTL7A methyltransferase like 7A
MKL1 megakaryoblastic leukemia (translocation) 1
MMRN2 multimerin 2
MPZL2 myelin protein zero-like 2
MRAS muscle RAS oncogene homolog
MTRF1L mitochondrial translational release factor 1-like
MXD3 MAX dimerization protein 3
NAB2 NGFI-A binding protein 2 (EGR1 binding protein 2)
PAK6 p21 protein (Cdc42/Rac)-activated kinase 6
PECAM1 platelet/endothelial cell adhesion molecule 1
PIN1P1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1 pseudogene 1
PKNOX1 PBX/knotted 1 homeobox 1
PLEKHG6 pleckstrin homology domain containing, family G (with RhoGef domain) member 6
PLXNC1 plexin C1
PPARD peroxisome proliferator-activated receptor delta
PRB3 proline-rich protein BstNI subfamily 3
PROL1 proline rich, lacrimal 1
PRPH2 peripherin 2 (retinal degeneration, slow)
PTPN18 protein tyrosine phosphatase, non-receptor type 18 (brain-derived)
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5
RIMS2 regulating synaptic membrane exocytosis 2
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SMARCA2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
SMG5 SMG5 nonsense mediated mRNA decay factor
SNRK SNF related kinase
SOGA1 suppressor of glucose, autophagy associated 1
SSH3 slingshot protein phosphatase 3
SSTR2 somatostatin receptor 2
STS steroid sulfatase (microsomal), isozyme S
SVEP1 sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1
SYK spleen tyrosine kinase
SYNJ2 synaptojanin 2
TACR1 tachykinin receptor 1
TAP2 transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)
TCP10 t-complex 10
TMEM63A transmembrane protein 63A
TMPRSS6 transmembrane protease, serine 6
TNIK TRAF2 and NCK interacting kinase
TRABD TraB domain containing
USP19 ubiquitin specific peptidase 19
UTP14A UTP14, U3 small nucleolar ribonucleoprotein, homolog A (yeast)
WWOX WW domain containing oxidoreductase
ZFAND6 zinc finger, AN1-type domain 6
ZMIZ2 zinc finger, MIZ-type containing 2

decreased expression

Symbol Name
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2
ACTR8 ARP8 actin-related protein 8 homolog (yeast)
ALKBH4 alkB, alkylation repair homolog 4 (E. coli)
APIP APAF1 interacting protein
ARID3B AT rich interactive domain 3B (BRIGHT-like)
BAG4 BCL2-associated athanogene 4
BCAS3 breast carcinoma amplified sequence 3
BGLAP bone gamma-carboxyglutamate (gla) protein
C1QTNF1 C1q and tumor necrosis factor related protein 1
CAPN15 calpain 15
CCDC68 coiled-coil domain containing 68
CCNT1 cyclin T1
CCZ1B CCZ1 vacuolar protein trafficking and biogenesis associated homolog B (S. cerevisiae)
CEP131 centrosomal protein 131kDa
COLGALT2 collagen beta(1-O)galactosyltransferase 2
CPOX coproporphyrinogen oxidase
DHX8 DEAH (Asp-Glu-Ala-His) box polypeptide 8
ECM1 extracellular matrix protein 1
EDC4 enhancer of mRNA decapping 4
ELOVL4 ELOVL fatty acid elongase 4
F8 coagulation factor VIII, procoagulant component
FAM50B family with sequence similarity 50, member B
FKBP1B FK506 binding protein 1B, 12.6 kDa
GJC1 gap junction protein, gamma 1, 45kDa
GNA13 guanine nucleotide binding protein (G protein), alpha 13
HAUS6 HAUS augmin-like complex, subunit 6
HIRA histone cell cycle regulator
HLX H2.0-like homeobox
HOXC13 homeobox C13
HSPB8 heat shock 22kDa protein 8
KDELC1 KDEL (Lys-Asp-Glu-Leu) containing 1
LBR lamin B receptor
LIG1 ligase I, DNA, ATP-dependent
LOC202181 SUMO-interacting motifs containing 1 pseudogene
LRFN3 leucine rich repeat and fibronectin type III domain containing 3
MAGOHB mago-nashi homolog B (Drosophila)
MAMLD1 mastermind-like domain containing 1
MAST3 microtubule associated serine/threonine kinase 3
MCRS1 microspherule protein 1
MEIS1 Meis homeobox 1
MICAL1 microtubule associated monooxygenase, calponin and LIM domain containing 1
MICAL3 microtubule associated monooxygenase, calponin and LIM domain containing 3
MLST8 MTOR associated protein, LST8 homolog (S. cerevisiae)
MN1 meningioma (disrupted in balanced translocation) 1
MNS1 meiosis-specific nuclear structural 1
MUC3B mucin 3B, cell surface associated
MUC7 mucin 7, secreted
MYL5 myosin, light chain 5, regulatory
MYO1E myosin IE
NADSYN1 NAD synthetase 1
NARFL nuclear prelamin A recognition factor-like
NOTCH1 notch 1
NT5E 5'-nucleotidase, ecto (CD73)
P2RX5 purinergic receptor P2X, ligand gated ion channel, 5
PACS1 phosphofurin acidic cluster sorting protein 1
PALB2 partner and localizer of BRCA2
PCYT2 phosphate cytidylyltransferase 2, ethanolamine
PEPD peptidase D
PER3 period circadian clock 3
PIEZO1 piezo-type mechanosensitive ion channel component 1
PLCD1 phospholipase C, delta 1
PLIN3 perilipin 3
PLSCR4 phospholipid scramblase 4
POM121 POM121 transmembrane nucleoporin
PRR3 proline rich 3
PRR7 proline rich 7 (synaptic)
PTPN13 protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)
RANBP17 RAN binding protein 17
RARS arginyl-tRNA synthetase
RASA2 RAS p21 protein activator 2
RNF31 ring finger protein 31
RRN3 RRN3 RNA polymerase I transcription factor homolog (S. cerevisiae)
SGMS1 sphingomyelin synthase 1
SH3TC2 SH3 domain and tetratricopeptide repeats 2
SLC10A3 solute carrier family 10, member 3
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10
SLC39A1 solute carrier family 39 (zinc transporter), member 1
SLC43A1 solute carrier family 43 (amino acid system L transporter), member 1
SLC4A2 solute carrier family 4 (anion exchanger), member 2
SMEK2 SMEK homolog 2, suppressor of mek1 (Dictyostelium)
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase
SNORA21 small nucleolar RNA, H/ACA box 21
SPATA2L spermatogenesis associated 2-like
TGIF1 TGFB-induced factor homeobox 1
THAP1 THAP domain containing, apoptosis associated protein 1
TIMM50 translocase of inner mitochondrial membrane 50 homolog (S. cerevisiae)
TMEM121 transmembrane protein 121
TMEM156 transmembrane protein 156
TMEM159 transmembrane protein 159
TMEM2 transmembrane protein 2
TMUB2 transmembrane and ubiquitin-like domain containing 2
TUBA3C tubulin, alpha 3c
UQCC1 ubiquinol-cytochrome c reductase complex assembly factor 1
USP5 ubiquitin specific peptidase 5 (isopeptidase T)
WDR5B WD repeat domain 5B
ZFYVE16 zinc finger, FYVE domain containing 16
ZNF442 zinc finger protein 442
ZNF552 zinc finger protein 552
ZNF571 zinc finger protein 571