baclofen Gene Set

Dataset LINCS L1000 CMAP Chemical Perturbation Consensus Signatures
Category transcriptomics
Type small molecule perturbation
Description A monocarboxylic acid that is butanoic acid substituted by an amino group at position 4 and a 4-chlorophenyl group at position 3. It acts as a central nervous system depressant, GABA agonist and muscle relaxant. (Chemical Entities of Biological Interest Ontology, CHEBI_2972)
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Genes

7 genes differentially expressed following the baclofen small molecule perturbation from the LINCS L1000 CMAP Chemical Perturbation Consensus Signatures dataset.

increased expression

Symbol Name Standardized Value
LMO3 LIM domain only 3 (rhombotin-like 2) 3.58896
SNAP25 synaptosomal-associated protein, 25kDa 3.29422
TLR4 toll-like receptor 4 3.20775
DFFB DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase) 3.1753

decreased expression

Symbol Name Standardized Value
E2F2 E2F transcription factor 2 -3.52872
CANT1 calcium activated nucleotidase 1 -3.09504
LINC00652 long intergenic non-protein coding RNA 652 -3.00065