bad Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description BCL2-associated agonist of cell death|The protein encoded by this gene is a member of the BCL-2 family. BCL-2 family members are known to be regulators of programmed cell death. This protein positively regulates cell apoptosis by forming heterodimers with BCL-xL and BCL-2, and reversing their death repressor activity. Proapoptotic activity of this protein is regulated through its phosphorylation. Protein kinases AKT and MAP kinase, as well as protein phosphatase calcineurin were found to be involved in the regulation of this protein. Alternative splicing of this gene results in two transcript variants which encode the same isoform. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 572)
Similar Terms
Downloads & Tools

Genes

91 genes co-occuring with the biological term bad in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
AKT1 v-akt murine thymoma viral oncogene homolog 1
ALOX5 arachidonate 5-lipoxygenase
ANGPT2 angiopoietin 2
APAF1 apoptotic peptidase activating factor 1
AREG amphiregulin
ARRB2 arrestin, beta 2
BAD BCL2-associated agonist of cell death
BAK1 BCL2-antagonist/killer 1
BAX BCL2-associated X protein
BBC3 BCL2 binding component 3
BCL2 B-cell CLL/lymphoma 2
BCL2L1 BCL2-like 1
BCL2L11 BCL2-like 11 (apoptosis facilitator)
BCL2L14 BCL2-like 14 (apoptosis facilitator)
BID BH3 interacting domain death agonist
BIRC3 baculoviral IAP repeat containing 3
BIRC5 baculoviral IAP repeat containing 5
BMF Bcl2 modifying factor
BRAF B-Raf proto-oncogene, serine/threonine kinase
CASR calcium-sensing receptor
CAV1 caveolin 1, caveolae protein, 22kDa
CCND1 cyclin D1
CDK2AP1 cyclin-dependent kinase 2 associated protein 1
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CRP C-reactive protein, pentraxin-related
DEPDC1 DEP domain containing 1
EGF epidermal growth factor
EGFR epidermal growth factor receptor
ENDOG endonuclease G
ERBB2 erb-b2 receptor tyrosine kinase 2
ESR2 estrogen receptor 2 (ER beta)
FAM32A family with sequence similarity 32, member A
FAS Fas cell surface death receptor
FGFR1 fibroblast growth factor receptor 1
FHIT fragile histidine triad
FOXO3 forkhead box O3
GSTP1 glutathione S-transferase pi 1
HDGF hepatoma-derived growth factor
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HMOX1 heme oxygenase 1
HSPA4 heat shock 70kDa protein 4
HSPB2 heat shock 27kDa protein 2
HUS1 HUS1 checkpoint homolog (S. pombe)
IGF1 insulin-like growth factor 1 (somatomedin C)
IGF1R insulin-like growth factor 1 receptor
IL4 interleukin 4
IL6 interleukin 6
LGALS1 lectin, galactoside-binding, soluble, 1
MAP4K3 mitogen-activated protein kinase kinase kinase kinase 3
MAPK1 mitogen-activated protein kinase 1
MAPT microtubule-associated protein tau
MCL1 myeloid cell leukemia 1
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MN1 meningioma (disrupted in balanced translocation) 1
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
NME1 NME/NM23 nucleoside diphosphate kinase 1
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin)
PAK1 p21 protein (Cdc42/Rac)-activated kinase 1
PARP1 poly (ADP-ribose) polymerase 1
PDGFC platelet derived growth factor C
PHB prohibitin
PIM1 Pim-1 proto-oncogene, serine/threonine kinase
PIM2 Pim-2 proto-oncogene, serine/threonine kinase
PPARA peroxisome proliferator-activated receptor alpha
PRKCDBP protein kinase C, delta binding protein
PRKCI protein kinase C, iota
PRKG1 protein kinase, cGMP-dependent, type I
PRMT1 protein arginine methyltransferase 1
PTH parathyroid hormone
RAF1 Raf-1 proto-oncogene, serine/threonine kinase
REG1A regenerating islet-derived 1 alpha
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
RELN reelin
S100B S100 calcium binding protein B
SMYD2 SET and MYND domain containing 2
SNCA synuclein, alpha (non A4 component of amyloid precursor)
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
THEM4 thioesterase superfamily member 4
TNF tumor necrosis factor
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TP53 tumor protein p53
TP73 tumor protein p73
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
VIM vimentin
VIP vasoactive intestinal peptide
XIAP X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta
ZMYM2 zinc finger, MYM-type 2