bax Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description BCL2-associated X protein|The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein forms a heterodimer with BCL2, and functions as an apoptotic activator. This protein is reported to interact with, and increase the opening of, the mitochondrial voltage-dependent anion channel (VDAC), which leads to the loss in membrane potential and the release of cytochrome c. The expression of this gene is regulated by the tumor suppressor P53 and has been shown to be involved in P53-mediated apoptosis. Multiple alternatively spliced transcript variants, which encode different isoforms, have been reported for this gene. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 581)
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Genes

244 genes co-occuring with the biological term bax in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ADM adrenomedullin
AKT1 v-akt murine thymoma viral oncogene homolog 1
ANXA2 annexin A2
APP amyloid beta (A4) precursor protein
AREG amphiregulin
ATR ATR serine/threonine kinase
ATXN3 ataxin 3
BAD BCL2-associated agonist of cell death
BAK1 BCL2-antagonist/killer 1
BANP BTG3 associated nuclear protein
BAX BCL2-associated X protein
BBC3 BCL2 binding component 3
BCL2 B-cell CLL/lymphoma 2
BCL2A1 BCL2-related protein A1
BCL2L1 BCL2-like 1
BCL2L10 BCL2-like 10 (apoptosis facilitator)
BCL2L11 BCL2-like 11 (apoptosis facilitator)
BCL2L12 BCL2-like 12 (proline rich)
BECN1 beclin 1, autophagy related
BID BH3 interacting domain death agonist
BIRC3 baculoviral IAP repeat containing 3
BIRC5 baculoviral IAP repeat containing 5
BRCA1 breast cancer 1, early onset
CAPN1 calpain 1, (mu/I) large subunit
CASP1 caspase 1, apoptosis-related cysteine peptidase
CASP2 caspase 2, apoptosis-related cysteine peptidase
CASP3 caspase 3, apoptosis-related cysteine peptidase
CASP5 caspase 5, apoptosis-related cysteine peptidase
CASP6 caspase 6, apoptosis-related cysteine peptidase
CASP8 caspase 8, apoptosis-related cysteine peptidase
CASP9 caspase 9, apoptosis-related cysteine peptidase
CAST calpastatin
CCL21 chemokine (C-C motif) ligand 21
CCND1 cyclin D1
CCNE1 cyclin E1
CCR7 chemokine (C-C motif) receptor 7
CD40 CD40 molecule, TNF receptor superfamily member 5
CD40LG CD40 ligand
CDK1 cyclin-dependent kinase 1
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CDKN2A cyclin-dependent kinase inhibitor 2A
CERS5 ceramide synthase 5
CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)
CGB chorionic gonadotropin, beta polypeptide
CHRNA3 cholinergic receptor, nicotinic, alpha 3 (neuronal)
CIAPIN1 cytokine induced apoptosis inhibitor 1
CKLF chemokine-like factor
CLIC4 chloride intracellular channel 4
CLU clusterin
COX6C cytochrome c oxidase subunit VIc
COX7B cytochrome c oxidase subunit VIIb
CPT1A carnitine palmitoyltransferase 1A (liver)
CREB1 cAMP responsive element binding protein 1
CTBP1 C-terminal binding protein 1
CTCF CCCTC-binding factor (zinc finger protein)
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CTSD cathepsin D
CYC1 cytochrome c-1
CYCS cytochrome c, somatic
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1
DEAF1 DEAF1 transcription factor
DIABLO diablo, IAP-binding mitochondrial protein
DNM1L dynamin 1-like
DYRK1B dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B
EGFR epidermal growth factor receptor
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2
ELAVL1 ELAV like RNA binding protein 1
ELK1 ELK1, member of ETS oncogene family
ENO2 enolase 2 (gamma, neuronal)
ERBB2 erb-b2 receptor tyrosine kinase 2
ERCC2 excision repair cross-complementation group 2
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
ETV4 ets variant 4
F2 coagulation factor II (thrombin)
FAS Fas cell surface death receptor
FASLG Fas ligand (TNF superfamily, member 6)
GADD45A growth arrest and DNA-damage-inducible, alpha
GAST gastrin
GFI1 growth factor independent 1 transcription repressor
GJA1 gap junction protein, alpha 1, 43kDa
GNL3L guanine nucleotide binding protein-like 3 (nucleolar)-like
GNRH1 gonadotropin-releasing hormone 1 (luteinizing-releasing hormone)
GPX1 glutathione peroxidase 1
GRAMD4 GRAM domain containing 4
GSK3B glycogen synthase kinase 3 beta
HDAC6 histone deacetylase 6
HEPN1 hepatocellular carcinoma, down-regulated 1
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HIST1H1C histone cluster 1, H1c
HMOX1 heme oxygenase 1
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A)
HRAS Harvey rat sarcoma viral oncogene homolog
HSPA1A heat shock 70kDa protein 1A
HSPA4 heat shock 70kDa protein 4
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HSPB2 heat shock 27kDa protein 2
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa
HTRA2 HtrA serine peptidase 2
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IFI27 interferon, alpha-inducible protein 27
IFNGR2 interferon gamma receptor 2 (interferon gamma transducer 1)
IGF1 insulin-like growth factor 1 (somatomedin C)
IGF2R insulin-like growth factor 2 receptor
IL4 interleukin 4
IL6 interleukin 6
IL7 interleukin 7
IL7R interleukin 7 receptor
INHBA inhibin, beta A
IRF3 interferon regulatory factor 3
JTB jumping translocation breakpoint
KAZN kazrin, periplakin interacting protein
KCNA3 potassium channel, voltage gated shaker related subfamily A, member 3
KRT7 keratin 7, type II
LCMT2 leucine carboxyl methyltransferase 2
LCN2 lipocalin 2
LEP leptin
LMNA lamin A/C
MAP2K3 mitogen-activated protein kinase kinase 3
MAP2K4 mitogen-activated protein kinase kinase 4
MAP4K3 mitogen-activated protein kinase kinase kinase kinase 3
MAPK1 mitogen-activated protein kinase 1
MAPK14 mitogen-activated protein kinase 14
MAPK3 mitogen-activated protein kinase 3
MCL1 myeloid cell leukemia 1
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MED19 mediator complex subunit 19
MFN1 mitofusin 1
MFN2 mitofusin 2
MIR19A microRNA 19a
MIR214 microRNA 214
MIR34A microRNA 34a
MIR365A microRNA 365a
MIR511 microRNA 511
MIR663A microRNA 663a
MOAP1 modulator of apoptosis 1
MS4A1 membrane-spanning 4-domains, subfamily A, member 1
MSH3 mutS homolog 3
MSH6 mutS homolog 6
MST1 macrophage stimulating 1
MTAP methylthioadenosine phosphorylase
MTCH2 mitochondrial carrier 2
MTOR mechanistic target of rapamycin (serine/threonine kinase)
MUC1 mucin 1, cell surface associated
MYC v-myc avian myelocytomatosis viral oncogene homolog
NES nestin
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain)
NOS2 nitric oxide synthase 2, inducible
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin)
NR4A1 nuclear receptor subfamily 4, group A, member 1
NRP1 neuropilin 1
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1
NUCLEOLIN nucleolin multifunctional protein
OLR1 oxidized low density lipoprotein (lectin-like) receptor 1
PARP1 poly (ADP-ribose) polymerase 1
PAX3 paired box 3
PDGFB platelet-derived growth factor beta polypeptide
PECAM1 platelet/endothelial cell adhesion molecule 1
PEG3 paternally expressed 3
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
PINK1 PTEN induced putative kinase 1
PLA2G3 phospholipase A2, group III
PLK1 polo-like kinase 1
PON1 paraoxonase 1
PPARG peroxisome proliferator-activated receptor gamma
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D
PPP1R13L protein phosphatase 1, regulatory subunit 13 like
PPP2R4 protein phosphatase 2A activator, regulatory subunit 4
PRKCA protein kinase C, alpha
PRKCB protein kinase C, beta
PRKCD protein kinase C, delta
PRKCE protein kinase C, epsilon
PRKCZ protein kinase C, zeta
PRL prolactin
PRNP prion protein
PSIP1 PC4 and SFRS1 interacting protein 1
PSMD10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10
PTEN phosphatase and tensin homolog
PTGES3 prostaglandin E synthase 3 (cytosolic)
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PURA purine-rich element binding protein A
PYCARD PYD and CARD domain containing
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
RAF1 Raf-1 proto-oncogene, serine/threonine kinase
RASSF1 Ras association (RalGDS/AF-6) domain family member 1
RB1 retinoblastoma 1
RND3 Rho family GTPase 3
RNF144B ring finger protein 144B
RUNX2 runt-related transcription factor 2
SALL2 spalt-like transcription factor 2
SEPT7 septin 7
SH3GLB1 SH3-domain GRB2-like endophilin B1
SIRT1 sirtuin 1
SLC25A4 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1
SMPD1 sphingomyelin phosphodiesterase 1, acid lysosomal
SOD1 superoxide dismutase 1, soluble
SRC SRC proto-oncogene, non-receptor tyrosine kinase
SST somatostatin
SSTR2 somatostatin receptor 2
STAR steroidogenic acute regulatory protein
STAT1 signal transducer and activator of transcription 1, 91kDa
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TGFB1 transforming growth factor, beta 1
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TGM2 transglutaminase 2
TIMP1 TIMP metallopeptidase inhibitor 1
TMBIM6 transmembrane BAX inhibitor motif containing 6
TMEM158 transmembrane protein 158 (gene/pseudogene)
TNF tumor necrosis factor
TNFRSF10A tumor necrosis factor receptor superfamily, member 10a
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TNFSF13 tumor necrosis factor (ligand) superfamily, member 13
TNFSF13B tumor necrosis factor (ligand) superfamily, member 13b
TOMM22 translocase of outer mitochondrial membrane 22 homolog (yeast)
TP53 tumor protein p53
TP63 tumor protein p63
TP73 tumor protein p73
TPPP tubulin polymerization promoting protein
TPT1 tumor protein, translationally-controlled 1
UTRN utrophin
UVRAG UV radiation resistance associated
VAV1 vav 1 guanine nucleotide exchange factor
VDAC2 voltage-dependent anion channel 2
VEGFA vascular endothelial growth factor A
VPS53 vacuolar protein sorting 53 homolog (S. cerevisiae)
VRK2 vaccinia related kinase 2
WISP1 WNT1 inducible signaling pathway protein 1
XAF1 XIAP associated factor 1
XIAP X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase
XRCC3 X-ray repair complementing defective repair in Chinese hamster cells 3
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6
XRCC6P2 X-ray repair complementing defective repair in Chinese hamster cells 6 pseudogene 2
YAP1 Yes-associated protein 1
YBX1 Y box binding protein 1
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta
ZKSCAN1 zinc finger with KRAB and SCAN domains 1