bcl-2 family protein complex Gene Set

Dataset COMPARTMENTS Text-mining Protein Localization Evidence Scores
Category structural or functional annotations
Type cellular component
Description A protein complex that consists of members of the Bcl-2 family of anti- and proapoptotic regulators. Bcl-2 proteins respond to cues from various forms of intracellular stress, such as DNA damage or cytokine deprivation, and interact with opposing family members to determine whether or not the caspase proteolytic cascade should be unleashed. (Gene Ontology, GO_0097136)
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67 proteins co-occuring with the bcl-2 family protein complex cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.

Symbol Name Standardized Value
BAX BCL2-associated X protein 1.23348
BECN1 beclin 1, autophagy related 1.10205
BAD BCL2-associated agonist of cell death 1.10103
BCL2L1 BCL2-like 1 0.923728
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6 0.838728
CASP3 caspase 3, apoptosis-related cysteine peptidase 0.715014
BCL2L11 BCL2-like 11 (apoptosis facilitator) 0.659913
VDAC2 voltage-dependent anion channel 2 0.626909
DRAM1 DNA-damage regulated autophagy modulator 1 0.592652
TP53 tumor protein p53 0.54936
WISP1 WNT1 inducible signaling pathway protein 1 0.54771
MTCH2 mitochondrial carrier 2 0.546472
HRK harakiri, BCL2 interacting protein 0.524704
EGLN3 egl-9 family hypoxia-inducible factor 3 0.514085
WNT1 wingless-type MMTV integration site family, member 1 0.512862
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.468401
CD70 CD70 molecule 0.452029
UVRAG UV radiation resistance associated 0.427891
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.382354
SQSTM1 sequestosome 1 0.375434
NR4A1 nuclear receptor subfamily 4, group A, member 1 0.352522
TMEM173 transmembrane protein 173 0.335864
CASP8 caspase 8, apoptosis-related cysteine peptidase 0.323825
RNASEL ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent) 0.296972
NRAS neuroblastoma RAS viral (v-ras) oncogene homolog 0.293267
S100A8 S100 calcium binding protein A8 0.268969
SAMHD1 SAM domain and HD domain 1 0.260202
DIABLO diablo, IAP-binding mitochondrial protein 0.249664
CD27 CD27 molecule 0.224558
CASP9 caspase 9, apoptosis-related cysteine peptidase 0.211587
ROCK1P1 Rho-associated, coiled-coil containing protein kinase 1 pseudogene 1 0.21124
L1CAM L1 cell adhesion molecule 0.205059
BCL2 B-cell CLL/lymphoma 2 0.192423
TOMM40 translocase of outer mitochondrial membrane 40 homolog (yeast) 0.183935
CLU clusterin 0.180634
KRAS Kirsten rat sarcoma viral oncogene homolog 0.177154
MAPK8 mitogen-activated protein kinase 8 0.161905
ROCK1 Rho-associated, coiled-coil containing protein kinase 1 0.161484
CDC25C cell division cycle 25C 0.159268
GCK glucokinase (hexokinase 4) 0.120294
CD40LG CD40 ligand 0.118082
ADM adrenomedullin 0.113719
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.109947
ATR ATR serine/threonine kinase 0.105869
CA2 carbonic anhydrase II 0.103916
IGFBP1 insulin-like growth factor binding protein 1 0.103509
ESR2 estrogen receptor 2 (ER beta) 0.103155
MET MET proto-oncogene, receptor tyrosine kinase 0.101924
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble 0.099062
COL18A1 collagen, type XVIII, alpha 1 0.098069
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3 0.097943
VDAC1 voltage-dependent anion channel 1 0.096797
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 0.096115
HRAS Harvey rat sarcoma viral oncogene homolog 0.095324
RAD50 RAD50 homolog (S. cerevisiae) 0.094316
PAK1 p21 protein (Cdc42/Rac)-activated kinase 1 0.093908
IRF3 interferon regulatory factor 3 0.093704
CD68 CD68 molecule 0.093185
H2AFX H2A histone family, member X 0.091032
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10 0.090889
CDSN corneodesmosin 0.090599
MRE11A MRE11 meiotic recombination 11 homolog A (S. cerevisiae) 0.090381
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.090163
DNTT DNA nucleotidylexotransferase 0.086529
FOXP3 forkhead box P3 0.086336
ATM ATM serine/threonine kinase 0.083673
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial 0.083633