bcl-2 Gene Set

Dataset Phosphosite Textmining Biological Term Annotations
Category structural or functional annotations
Type biological term
Description B-cell CLL/lymphoma 2|This gene encodes an integral outer mitochondrial membrane protein that blocks the apoptotic death of some cells such as lymphocytes. Constitutive expression of BCL2, such as in the case of translocation of BCL2 to Ig heavy chain locus, is thought to be the cause of follicular lymphoma. Two transcript variants, produced by alternate splicing, differ in their C-terminal ends. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 596)
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Genes

130 proteins co-occuring with the biological term bcl-2 in abstracts of publications describing phosphosites from the Phosphosite Textmining Biological Term Annotations dataset.

Symbol Name
ACACA acetyl-CoA carboxylase alpha
AKT1 v-akt murine thymoma viral oncogene homolog 1
AKT1S1 AKT1 substrate 1 (proline-rich)
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2
ATF1 activating transcription factor 1
ATM ATM serine/threonine kinase
BAD BCL2-associated agonist of cell death
BAG3 BCL2-associated athanogene 3
BAK1 BCL2-antagonist/killer 1
BAX BCL2-associated X protein
BBC3 BCL2 binding component 3
BCL2 B-cell CLL/lymphoma 2
BCL2L1 BCL2-like 1
BCL2L11 BCL2-like 11 (apoptosis facilitator)
BCL2L12 BCL2-like 12 (proline rich)
BCR breakpoint cluster region
BECN1 beclin 1, autophagy related
BID BH3 interacting domain death agonist
BIK BCL2-interacting killer (apoptosis-inducing)
BIRC5 baculoviral IAP repeat containing 5
BMF Bcl2 modifying factor
BMX BMX non-receptor tyrosine kinase
CAMK2A calcium/calmodulin-dependent protein kinase II alpha
CAMK2B calcium/calmodulin-dependent protein kinase II beta
CAMK2G calcium/calmodulin-dependent protein kinase II gamma
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase
CDC25A cell division cycle 25A
CDC25C cell division cycle 25C
CDK1 cyclin-dependent kinase 1
CDK2 cyclin-dependent kinase 2
CHEK1 checkpoint kinase 1
CHEK2 checkpoint kinase 2
CHUK conserved helix-loop-helix ubiquitous kinase
CREB1 cAMP responsive element binding protein 1
CRKL v-crk avian sarcoma virus CT10 oncogene homolog-like
CSF2RB colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)
CTBP1 C-terminal binding protein 1
DYNLL1 dynein, light chain, LC8-type 1
EGFR epidermal growth factor receptor
EIF2S1 eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa
EIF4E eukaryotic translation initiation factor 4E
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
ELK1 ELK1, member of ETS oncogene family
EPOR erythropoietin receptor
ERBB2 erb-b2 receptor tyrosine kinase 2
ESR1 estrogen receptor 1
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
FLT3 fms-related tyrosine kinase 3
FOXO1 forkhead box O1
FOXO3 forkhead box O3
GATA1 GATA binding protein 1 (globin transcription factor 1)
GSK3A glycogen synthase kinase 3 alpha
GSK3B glycogen synthase kinase 3 beta
H2AFX H2A histone family, member X
HIST1H3A histone cluster 1, H3a
HSPB1 heat shock 27kDa protein 1
HSPB6 heat shock protein, alpha-crystallin-related, B6
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma
IL7R interleukin 7 receptor
JAK1 Janus kinase 1
JAK2 Janus kinase 2
JUN jun proto-oncogene
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
LAT linker for activation of T cells
LCK LCK proto-oncogene, Src family tyrosine kinase
LGALS3 lectin, galactoside-binding, soluble, 3
MAP2K1 mitogen-activated protein kinase kinase 1
MAP2K2 mitogen-activated protein kinase kinase 2
MAP3K11 mitogen-activated protein kinase kinase kinase 11
MAP3K5 mitogen-activated protein kinase kinase kinase 5
MAPK1 mitogen-activated protein kinase 1
MAPK10 mitogen-activated protein kinase 10
MAPK14 mitogen-activated protein kinase 14
MAPK3 mitogen-activated protein kinase 3
MAPK8 mitogen-activated protein kinase 8
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2
MCL1 myeloid cell leukemia 1
MITF microphthalmia-associated transcription factor
MKNK1 MAP kinase interacting serine/threonine kinase 1
MTOR mechanistic target of rapamycin (serine/threonine kinase)
MYB v-myb avian myeloblastosis viral oncogene homolog
MYC v-myc avian myelocytomatosis viral oncogene homolog
NBN nibrin
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NR4A1 nuclear receptor subfamily 4, group A, member 1
PDPK1 3-phosphoinositide dependent protein kinase 1
PLCG1 phospholipase C, gamma 1
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa
PPP1CA protein phosphatase 1, catalytic subunit, alpha isozyme
PPP2R5A protein phosphatase 2, regulatory subunit B', alpha
PRKAA1 protein kinase, AMP-activated, alpha 1 catalytic subunit
PRKACA protein kinase, cAMP-dependent, catalytic, alpha
PRKCD protein kinase C, delta
PRKCI protein kinase C, iota
PRKD1 protein kinase D1
PRKDC protein kinase, DNA-activated, catalytic polypeptide
PTK2 protein tyrosine kinase 2
PTRH2 peptidyl-tRNA hydrolase 2
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
RAD9A RAD9 homolog A (S. pombe)
RAF1 Raf-1 proto-oncogene, serine/threonine kinase
RB1 retinoblastoma 1
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
RET ret proto-oncogene
RPS6 ribosomal protein S6
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1
RPS6KB1 ribosomal protein S6 kinase, 70kDa, polypeptide 1
SFN stratifin
SH3GLB1 SH3-domain GRB2-like endophilin B1
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SPI1 Spi-1 proto-oncogene
SRC SRC proto-oncogene, non-receptor tyrosine kinase
STAT1 signal transducer and activator of transcription 1, 91kDa
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
STAT5A signal transducer and activator of transcription 5A
TP53 tumor protein p53
TP73 tumor protein p73
TRIM28 tripartite motif containing 28
TSC2 tuberous sclerosis 2
WWOX WW domain containing oxidoreductase
XIAP X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6
YAP1 Yes-associated protein 1
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta
ZNF420 zinc finger protein 420
ZNHIT1 zinc finger, HIT-type containing 1