bcl10 Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description B-cell CLL/lymphoma 10|This gene was identified by its translocation in a case of mucosa-associated lymphoid tissue (MALT) lymphoma. The protein encoded by this gene contains a caspase recruitment domain (CARD), and has been shown to induce apoptosis and to activate NF-kappaB. This protein is reported to interact with other CARD domain containing proteins including CARD9, 10, 11 and 14, which are thought to function as upstream regulators in NF-kappaB signaling. This protein is found to form a complex with MALT1, a protein encoded by another gene known to be translocated in MALT lymphoma. MALT1 and this protein are thought to synergize in the activation of NF-kappaB, and the deregulation of either of them may contribute to the same pathogenetic process that leads to the malignancy. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 8915)
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Genes

26 genes co-occuring with the biological term bcl10 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
BCL10 B-cell CLL/lymphoma 10
BCL2 B-cell CLL/lymphoma 2
BIRC3 baculoviral IAP repeat containing 3
CAMK2G calcium/calmodulin-dependent protein kinase II gamma
CARD10 caspase recruitment domain family, member 10
CARD11 caspase recruitment domain family, member 11
CRADD CASP2 and RIPK1 domain containing adaptor with death domain
CXCL8 chemokine (C-X-C motif) ligand 8
EPO erythropoietin
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma
IRAK1 interleukin-1 receptor-associated kinase 1
JUN jun proto-oncogene
MALT1 MALT1 paracaspase
MAP3K14 mitogen-activated protein kinase kinase kinase 14
MAP3K7 mitogen-activated protein kinase kinase kinase 7
MIB2 mindbomb E3 ubiquitin protein ligase 2
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
OCRL oculocerebrorenal syndrome of Lowe
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme
PPP3R1 protein phosphatase 3, regulatory subunit B, alpha
PRKCZ protein kinase C, zeta
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
STAT5B signal transducer and activator of transcription 5B
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase
VEGFA vascular endothelial growth factor A