bcl6 Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description B-cell CLL/lymphoma 6|The protein encoded by this gene is a zinc finger transcription factor and contains an N-terminal POZ domain. This protein acts as a sequence-specific repressor of transcription, and has been shown to modulate the transcription of START-dependent IL-4 responses of B cells. This protein can interact with a variety of POZ-containing proteins that function as transcription corepressors. This gene is found to be frequently translocated and hypermutated in diffuse large-cell lymphoma (DLCL), and may be involved in the pathogenesis of DLCL. Alternatively spliced transcript variants encoding different protein isoforms have been found for this gene. [provided by RefSeq, Sep 2008] (NCBI Entrez Gene Database, 604)
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Genes

91 genes co-occuring with the biological term bcl6 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
AICDA activation-induced cytidine deaminase
AKT1 v-akt murine thymoma viral oncogene homolog 1
ARF1 ADP-ribosylation factor 1
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein)
BCL2 B-cell CLL/lymphoma 2
BCL6 B-cell CLL/lymphoma 6
BCOR BCL6 corepressor
CCL2 chemokine (C-C motif) ligand 2
CCNB3 cyclin B3
CCND1 cyclin D1
CCND2 cyclin D2
CCNE1 cyclin E1
CD40 CD40 molecule, TNF receptor superfamily member 5
CD5 CD5 molecule
CD80 CD80 molecule
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like)
CDKN2A cyclin-dependent kinase inhibitor 2A
CHEK1 checkpoint kinase 1
CTBP1 C-terminal binding protein 1
CTCF CCCTC-binding factor (zinc finger protein)
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CXCL13 chemokine (C-X-C motif) ligand 13
DDX6 DEAD (Asp-Glu-Ala-Asp) box helicase 6
FAIM Fas apoptotic inhibitory molecule
FBXO11 F-box protein 11
FOXO3 forkhead box O3
FOXO4 forkhead box O4
FOXP1 forkhead box P1
GAS5 growth arrest-specific 5 (non-protein coding)
GCSAM germinal center-associated, signaling and motility
GH1 growth hormone 1
HBEGF heparin-binding EGF-like growth factor
HDAC5 histone deacetylase 5
HDAC7 histone deacetylase 7
HIC1 hypermethylated in cancer 1
IFNA2 interferon, alpha 2
IGH immunoglobulin heavy locus
IL21 interleukin 21
IL5 interleukin 5
IRF4 interferon regulatory factor 4
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit)
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
JAK2 Janus kinase 2
KRT5 keratin 5, type II
LITAF lipopolysaccharide-induced TNF factor
LMO2 LIM domain only 2 (rhombotin-like 1)
LPP LIM domain containing preferred translocation partner in lipoma
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MALT1 MALT1 paracaspase
MAPK14 mitogen-activated protein kinase 14
MEF2B myocyte enhancer factor 2B
MIR127 microRNA 127
MIR155 microRNA 155
MIR28 microRNA 28
MITF microphthalmia-associated transcription factor
MME membrane metallo-endopeptidase
MS4A1 membrane-spanning 4-domains, subfamily A, member 1
MTOR mechanistic target of rapamycin (serine/threonine kinase)
MUM1 melanoma associated antigen (mutated) 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
NCAM1 neural cell adhesion molecule 1
NCOR2 nuclear receptor corepressor 2
NFYA nuclear transcription factor Y, alpha
PATZ1 POZ (BTB) and AT hook containing zinc finger 1
PAX5 paired box 5
PDCD2 programmed cell death 2
PELI1 pellino E3 ubiquitin protein ligase 1
PIM1 Pim-1 proto-oncogene, serine/threonine kinase
POU2AF1 POU class 2 associating factor 1
POU2F2 POU class 2 homeobox 2
PRDM1 PR domain containing 1, with ZNF domain
PRL prolactin
PTPRO protein tyrosine phosphatase, receptor type, O
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
RGS4 regulator of G-protein signaling 4
SDC1 syndecan 1
SLC22A6 solute carrier family 22 (organic anion transporter), member 6
SMARCD3 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3
SPI1 Spi-1 proto-oncogene
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
STAT5A signal transducer and activator of transcription 5A
STAT5B signal transducer and activator of transcription 5B
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced
T T, brachyury homolog (mouse)
TCL1A T-cell leukemia/lymphoma 1A
TP53 tumor protein p53
TXNIP thioredoxin interacting protein
ZBTB17 zinc finger and BTB domain containing 17
ZEB1 zinc finger E-box binding homeobox 1
ZXDC ZXD family zinc finger C