bcr Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description breakpoint cluster region|A reciprocal translocation between chromosomes 22 and 9 produces the Philadelphia chromosome, which is often found in patients with chronic myelogenous leukemia. The chromosome 22 breakpoint for this translocation is located within the BCR gene. The translocation produces a fusion protein which is encoded by sequence from both BCR and ABL, the gene at the chromosome 9 breakpoint. Although the BCR-ABL fusion protein has been extensively studied, the function of the normal BCR gene product is not clear. The protein has serine/threonine kinase activity and is a GTPase-activating protein for p21rac. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 613)
Similar Terms
Downloads & Tools

Genes

64 genes co-occuring with the biological term bcr in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ABR active BCR-related
APBA3 amyloid beta (A4) precursor protein-binding, family A, member 3
ARHGDIA Rho GDP dissociation inhibitor (GDI) alpha
BCL2L11 BCL2-like 11 (apoptosis facilitator)
BCR breakpoint cluster region
BHLHE40 basic helix-loop-helix family, member e40
BLNK B-cell linker
BTLA B and T lymphocyte associated
CCL3 chemokine (C-C motif) ligand 3
CCL4 chemokine (C-C motif) ligand 4
CD19 CD19 molecule
CD27 CD27 molecule
CD40 CD40 molecule, TNF receptor superfamily member 5
CD40LG CD40 ligand
CD79A CD79a molecule, immunoglobulin-associated alpha
CD79B CD79b molecule, immunoglobulin-associated beta
CR2 complement component (3d/Epstein Barr virus) receptor 2
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CXCR4 chemokine (C-X-C motif) receptor 4
DDX39B DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B
DSG1 desmoglein 1
EGR1 early growth response 1
FCGR2B Fc fragment of IgG, low affinity IIb, receptor (CD32)
FCMR Fc fragment of IgM receptor
FCRL4 Fc receptor-like 4
FGFR1 fibroblast growth factor receptor 1
GZMB granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)
HMGB1 high mobility group box 1
HNF1A HNF1 homeobox A
HRAS Harvey rat sarcoma viral oncogene homolog
IGKV3-20 immunoglobulin kappa variable 3-20
IL21 interleukin 21
IL6 interleukin 6
JAK2 Janus kinase 2
JUN jun proto-oncogene
KMT2A lysine (K)-specific methyltransferase 2A
LAT2 linker for activation of T cells family, member 2
LPXN leupaxin
MAL mal, T-cell differentiation protein
MCL1 myeloid cell leukemia 1
MIR155HG MIR155 host gene
MLLT4 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4
MS4A1 membrane-spanning 4-domains, subfamily A, member 1
MTDH metadherin
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2
NR2C2 nuclear receptor subfamily 2, group C, member 2
NRXN1 neurexin 1
NUCB2 nucleobindin 2
PDZK1 PDZ domain containing 1
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
PRKCB protein kinase C, beta
RALA v-ral simian leukemia viral oncogene homolog A (ras related)
RHOA ras homolog family member A
RHOH ras homolog family member H
SELL selectin L
SOD2 superoxide dismutase 2, mitochondrial
SRC SRC proto-oncogene, non-receptor tyrosine kinase
SYK spleen tyrosine kinase
TGM2 transglutaminase 2
TLR9 toll-like receptor 9
TNFSF13B tumor necrosis factor (ligand) superfamily, member 13b
TP53 tumor protein p53
ZAP70 zeta-chain (TCR) associated protein kinase 70kDa