bcr Gene Set

Dataset Phosphosite Textmining Biological Term Annotations
Category structural or functional annotations
Type biological term
Description breakpoint cluster region|A reciprocal translocation between chromosomes 22 and 9 produces the Philadelphia chromosome, which is often found in patients with chronic myelogenous leukemia. The chromosome 22 breakpoint for this translocation is located within the BCR gene. The translocation produces a fusion protein which is encoded by sequence from both BCR and ABL, the gene at the chromosome 9 breakpoint. Although the BCR-ABL fusion protein has been extensively studied, the function of the normal BCR gene product is not clear. The protein has serine/threonine kinase activity and is a GTPase-activating protein for p21rac. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 613)
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Genes

50 proteins co-occuring with the biological term bcr in abstracts of publications describing phosphosites from the Phosphosite Textmining Biological Term Annotations dataset.

Symbol Name
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
AKT1 v-akt murine thymoma viral oncogene homolog 1
BCR breakpoint cluster region
BLNK B-cell linker
BRAF B-Raf proto-oncogene, serine/threonine kinase
BTK Bruton agammaglobulinemia tyrosine kinase
CARD11 caspase recruitment domain family, member 11
CD19 CD19 molecule
CD22 CD22 molecule
CD40 CD40 molecule, TNF receptor superfamily member 5
CD5 CD5 molecule
CD79A CD79a molecule, immunoglobulin-associated alpha
CHUK conserved helix-loop-helix ubiquitous kinase
CREB1 cAMP responsive element binding protein 1
DAPP1 dual adaptor of phosphotyrosine and 3-phosphoinositides
EZR ezrin
FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32)
FCGR2B Fc fragment of IgG, low affinity IIb, receptor (CD32)
FCGR2C Fc fragment of IgG, low affinity IIc, receptor for (CD32) (gene/pseudogene)
FCRL4 Fc receptor-like 4
FES FES proto-oncogene, tyrosine kinase
GP1BA glycoprotein Ib (platelet), alpha polypeptide
HCLS1 hematopoietic cell-specific Lyn substrate 1
IBTK inhibitor of Bruton agammaglobulinemia tyrosine kinase
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
INPP5D inositol polyphosphate-5-phosphatase, 145kDa
LIME1 Lck interacting transmembrane adaptor 1
LPXN leupaxin
LYN LYN proto-oncogene, Src family tyrosine kinase
MAP4K1 mitogen-activated protein kinase kinase kinase kinase 1
MAPK1 mitogen-activated protein kinase 1
MAPK14 mitogen-activated protein kinase 14
MAPK3 mitogen-activated protein kinase 3
MAPK8 mitogen-activated protein kinase 8
MLLT4 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
PLCG2 phospholipase C, gamma 2 (phosphatidylinositol-specific)
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated)
RASGRP3 RAS guanyl releasing protein 3 (calcium and DAG-regulated)
RB1 retinoblastoma 1
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1
RPS6KA5 ribosomal protein S6 kinase, 90kDa, polypeptide 5
SH3BP2 SH3-domain binding protein 2
STAP2 signal transducing adaptor family member 2
STAT1 signal transducer and activator of transcription 1, 91kDa
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
SYK spleen tyrosine kinase
TP53 tumor protein p53
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta