bdnf Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description brain-derived neurotrophic factor|The protein encoded by this gene is a member of the nerve growth factor family. It is induced by cortical neurons, and is necessary for survival of striatal neurons in the brain. Expression of this gene is reduced in both Alzheimer's and Huntington disease patients. This gene may play a role in the regulation of stress response and in the biology of mood disorders. Multiple transcript variants encoding distinct isoforms have been described for this gene. [provided by RefSeq, Jan 2009] (NCBI Entrez Gene Database, 627)
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Genes

124 genes co-occuring with the biological term bdnf in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ADORA2A adenosine A2a receptor
ADRA2A adrenoceptor alpha 2A
AKT1 v-akt murine thymoma viral oncogene homolog 1
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
APOE apolipoprotein E
BDNF brain-derived neurotrophic factor
CALCA calcitonin-related polypeptide alpha
CAMK1 calcium/calmodulin-dependent protein kinase I
CARF calcium responsive transcription factor
CCL5 chemokine (C-C motif) ligand 5
CD40 CD40 molecule, TNF receptor superfamily member 5
CHRNA5 cholinergic receptor, nicotinic, alpha 5 (neuronal)
CHUK conserved helix-loop-helix ubiquitous kinase
CLDN5 claudin 5
CNR1 cannabinoid receptor 1 (brain)
CNTF ciliary neurotrophic factor
COMT catechol-O-methyltransferase
CREB1 cAMP responsive element binding protein 1
CREM cAMP responsive element modulator
CRHR1 corticotropin releasing hormone receptor 1
DCX doublecortin
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DRD2 dopamine receptor D2
DRD3 dopamine receptor D3
DTNBP1 dystrobrevin binding protein 1
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A
EGFR epidermal growth factor receptor
ERVW-1 endogenous retrovirus group W, member 1
FAIM2 Fas apoptotic inhibitory molecule 2
FGF2 fibroblast growth factor 2 (basic)
FOXO3 forkhead box O3
FTO fat mass and obesity associated
GABRA1 gamma-aminobutyric acid (GABA) A receptor, alpha 1
GABRA2 gamma-aminobutyric acid (GABA) A receptor, alpha 2
GAD1 glutamate decarboxylase 1 (brain, 67kDa)
GCG glucagon
GDNF glial cell derived neurotrophic factor
GHRL ghrelin/obestatin prepropeptide
GNB2L1 guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1
GNPDA2 glucosamine-6-phosphate deaminase 2
GSK3B glycogen synthase kinase 3 beta
HAP1 huntingtin-associated protein 1
HIST4H4 histone cluster 4, H4
HK2 hexokinase 2
HMOX1 heme oxygenase 1
HTR1A 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled
HTR2A 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled
HTT huntingtin
IFNA1 interferon, alpha 1
IGF1 insulin-like growth factor 1 (somatomedin C)
IGF2 insulin-like growth factor 2
IL2 interleukin 2
IL6 interleukin 6
ITGB5 integrin, beta 5
KITLG KIT ligand
LEP leptin
LGALS1 lectin, galactoside-binding, soluble, 1
LIN7A lin-7 homolog A (C. elegans)
LIN7B lin-7 homolog B (C. elegans)
LIN7C lin-7 homolog C (C. elegans)
LRRK2 leucine-rich repeat kinase 2
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MAP2K1 mitogen-activated protein kinase kinase 1
MAPK8IP3 mitogen-activated protein kinase 8 interacting protein 3
MC4R melanocortin 4 receptor
MECP2 methyl CpG binding protein 2
MIR16-1 microRNA 16-1
MIR206 microRNA 206
MIR22 microRNA 22
MIR26A1 microRNA 26a-1
MIR26B microRNA 26b
MIR30A microRNA 30a
MMP9 matrix metallopeptidase 9
MTCH2 mitochondrial carrier 2
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
NCAM1 neural cell adhesion molecule 1
NEGR1 neuronal growth regulator 1
NGF nerve growth factor (beta polypeptide)
NGFR nerve growth factor receptor
NOS3 nitric oxide synthase 3 (endothelial cell)
NPY neuropeptide Y
NR4A2 nuclear receptor subfamily 4, group A, member 2
NRG1 neuregulin 1
NSFL1C NSFL1 (p97) cofactor (p47)
NTF3 neurotrophin 3
NTF4 neurotrophin 4
NTRK1 neurotrophic tyrosine kinase, receptor, type 1
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
NTRK3 neurotrophic tyrosine kinase, receptor, type 3
OPRM1 opioid receptor, mu 1
PARD6A par-6 family cell polarity regulator alpha
PDGFA platelet-derived growth factor alpha polypeptide
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
POU4F3 POU class 4 homeobox 3
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)
PPP1R1B protein phosphatase 1, regulatory (inhibitor) subunit 1B
PRODH proline dehydrogenase (oxidase) 1
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
RAI1 retinoic acid induced 1
RCOR1 REST corepressor 1
REST RE1-silencing transcription factor
RHOA ras homolog family member A
S100B S100 calcium binding protein B
SEC16B SEC16 homolog B (S. cerevisiae)
SH2B1 SH2B adaptor protein 1
SHH sonic hedgehog
SLC6A3 solute carrier family 6 (neurotransmitter transporter), member 3
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SORT1 sortilin 1
ST8SIA1 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
TGFB1 transforming growth factor, beta 1
TGFB2 transforming growth factor, beta 2
TGM1 transglutaminase 1
TH tyrosine hydroxylase
TMEM18 transmembrane protein 18
TNFSF11 tumor necrosis factor (ligand) superfamily, member 11
TRPC3 transient receptor potential cation channel, subfamily C, member 3
TSN translin
VCAM1 vascular cell adhesion molecule 1
VEGFA vascular endothelial growth factor A
VGF VGF nerve growth factor inducible
WT1 Wilms tumor 1