bendroflumethiazide-3415 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

196 genes differentially expressed following the bendroflumethiazide-3415 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADAM15 ADAM metallopeptidase domain 15
ADAP1 ArfGAP with dual PH domains 1
AEN apoptosis enhancing nuclease
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2
APOM apolipoprotein M
ARHGDIA Rho GDP dissociation inhibitor (GDI) alpha
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12
ARMC4 armadillo repeat containing 4
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
BRPF1 bromodomain and PHD finger containing, 1
C9ORF9 chromosome 9 open reading frame 9
CD82 CD82 molecule
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney)
CDK13 cyclin-dependent kinase 13
COMT catechol-O-methyltransferase
CTTN cortactin
DOC2A double C2-like domains, alpha
EGR3 early growth response 3
EXOC7 exocyst complex component 7
EXPH5 exophilin 5
FADS3 fatty acid desaturase 3
FKBP8 FK506 binding protein 8, 38kDa
GBP1 guanylate binding protein 1, interferon-inducible
GBP2 guanylate binding protein 2, interferon-inducible
GIF gastric intrinsic factor (vitamin B synthesis)
GIT2 G protein-coupled receptor kinase interacting ArfGAP 2
GPATCH4 G patch domain containing 4
GPR4 G protein-coupled receptor 4
HIST1H1D histone cluster 1, H1d
HIST1H2AL histone cluster 1, H2al
HIST1H4D histone cluster 1, H4d
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
ICAM1 intercellular adhesion molecule 1
IDI2-AS1 IDI2 antisense RNA 1
IL1B interleukin 1, beta
INCENP inner centromere protein antigens 135/155kDa
INSR insulin receptor
ITPK1 inositol-tetrakisphosphate 1-kinase
ITPKB inositol-trisphosphate 3-kinase B
KATNB1 katanin p80 (WD repeat containing) subunit B 1
LIG3 ligase III, DNA, ATP-dependent
LMAN1 lectin, mannose-binding, 1
MAP4K2 mitogen-activated protein kinase kinase kinase kinase 2
MAP9 microtubule-associated protein 9
MCAM melanoma cell adhesion molecule
MDM4 MDM4, p53 regulator
MEFV Mediterranean fever
MFSD11 major facilitator superfamily domain containing 11
MIIP migration and invasion inhibitory protein
MSMB microseminoprotein, beta-
MTA2 metastasis associated 1 family, member 2
MUC3A mucin 3A, cell surface associated
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
NEURL1 neuralized E3 ubiquitin protein ligase 1
NFIB nuclear factor I/B
NPFFR1 neuropeptide FF receptor 1
NR4A1 nuclear receptor subfamily 4, group A, member 1
NT5E 5'-nucleotidase, ecto (CD73)
NUP188 nucleoporin 188kDa
OLFML2A olfactomedin-like 2A
PARD6B par-6 family cell polarity regulator beta
PCGF3 polycomb group ring finger 3
PIM2 Pim-2 proto-oncogene, serine/threonine kinase
PLAUR plasminogen activator, urokinase receptor
PLEKHG3 pleckstrin homology domain containing, family G (with RhoGef domain) member 3
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
POLR3C polymerase (RNA) III (DNA directed) polypeptide C (62kD)
PTPRM protein tyrosine phosphatase, receptor type, M
RARA retinoic acid receptor, alpha
RASAL2 RAS protein activator like 2
RGS12 regulator of G-protein signaling 12
SAFB scaffold attachment factor B
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2
SMIM8 small integral membrane protein 8
SNAPC2 small nuclear RNA activating complex, polypeptide 2, 45kDa
SOGA1 suppressor of glucose, autophagy associated 1
STEAP4 STEAP family member 4
STK4 serine/threonine kinase 4
STRN3 striatin, calmodulin binding protein 3
SUN2 Sad1 and UNC84 domain containing 2
TDRKH tudor and KH domain containing
TFPI2 tissue factor pathway inhibitor 2
TGM2 transglutaminase 2
TK2 thymidine kinase 2, mitochondrial
TMCO6 transmembrane and coiled-coil domains 6
TMOD1 tropomodulin 1
TMPRSS3 transmembrane protease, serine 3
TNFRSF10C tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain
TPP1 tripeptidyl peptidase I
TSGA10 testis specific, 10
TUBA3C tubulin, alpha 3c
UNC119 unc-119 homolog (C. elegans)
VPS33A vacuolar protein sorting 33 homolog A (S. cerevisiae)
WDR55 WD repeat domain 55
WDR62 WD repeat domain 62
WSCD1 WSC domain containing 1
ZNF444 zinc finger protein 444

decreased expression

Symbol Name
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2
AGO1 argonaute RISC catalytic component 1
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
AP1B1 adaptor-related protein complex 1, beta 1 subunit
ARMC7 armadillo repeat containing 7
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1
BCL11B B-cell CLL/lymphoma 11B (zinc finger protein)
BCL9 B-cell CLL/lymphoma 9
BTBD3 BTB (POZ) domain containing 3
C11ORF95 chromosome 11 open reading frame 95
C4ORF29 chromosome 4 open reading frame 29
C5ORF45 chromosome 5 open reading frame 45
CALCOCO1 calcium binding and coiled-coil domain 1
CAPN1 calpain 1, (mu/I) large subunit
CASD1 CAS1 domain containing 1
CBX7 chromobox homolog 7
CEP72 centrosomal protein 72kDa
CEP97 centrosomal protein 97kDa
CLMN calmin (calponin-like, transmembrane)
CNKSR1 connector enhancer of kinase suppressor of Ras 1
CNP 2',3'-cyclic nucleotide 3' phosphodiesterase
COL4A5 collagen, type IV, alpha 5
CXORF56 chromosome X open reading frame 56
DGKD diacylglycerol kinase, delta 130kDa
E2F1 E2F transcription factor 1
EFNA3 ephrin-A3
ENC1 ectodermal-neural cortex 1 (with BTB domain)
EPB41L5 erythrocyte membrane protein band 4.1 like 5
EPHA4 EPH receptor A4
ERCC4 excision repair cross-complementation group 4
EVPL envoplakin
FANCE Fanconi anemia, complementation group E
FBXL2 F-box and leucine-rich repeat protein 2
FGD6 FYVE, RhoGEF and PH domain containing 6
FKBP14 FK506 binding protein 14, 22 kDa
FMO4 flavin containing monooxygenase 4
FOXK2 forkhead box K2
FURIN furin (paired basic amino acid cleaving enzyme)
FUZ fuzzy planar cell polarity protein
GBF1 golgi brefeldin A resistant guanine nucleotide exchange factor 1
GIPC1 GIPC PDZ domain containing family, member 1
GLS2 glutaminase 2 (liver, mitochondrial)
GRAMD4 GRAM domain containing 4
GTF2IRD1 GTF2I repeat domain containing 1
GTF3C5 general transcription factor IIIC, polypeptide 5, 63kDa
HIRA histone cell cycle regulator
HOXC13 homeobox C13
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
IGFBP6 insulin-like growth factor binding protein 6
IGSF1 immunoglobulin superfamily, member 1
IREB2 iron-responsive element binding protein 2
KDM5C lysine (K)-specific demethylase 5C
LINC00339 long intergenic non-protein coding RNA 339
LRP5L low density lipoprotein receptor-related protein 5-like
LZTR1 leucine-zipper-like transcription regulator 1
MBOAT2 membrane bound O-acyltransferase domain containing 2
MED15 mediator complex subunit 15
MID1IP1 MID1 interacting protein 1
MPP6 membrane protein, palmitoylated 6 (MAGUK p55 subfamily member 6)
MTHFSD methenyltetrahydrofolate synthetase domain containing
NEO1 neogenin 1
OGDH oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)
P2RY6 pyrimidinergic receptor P2Y, G-protein coupled, 6
PANK4 pantothenate kinase 4
PGPEP1 pyroglutamyl-peptidase I
PRRG2 proline rich Gla (G-carboxyglutamic acid) 2
RIPK4 receptor-interacting serine-threonine kinase 4
RNF170 ring finger protein 170
RPRM reprimo, TP53 dependent G2 arrest mediator candidate
SCAP SREBF chaperone
SCML2 sex comb on midleg-like 2 (Drosophila)
SHARPIN SHANK-associated RH domain interactor
SHPK sedoheptulokinase
SIK1 salt-inducible kinase 1
SIRT2 sirtuin 2
SLC20A2 solute carrier family 20 (phosphate transporter), member 2
SLC37A1 solute carrier family 37 (glucose-6-phosphate transporter), member 1
SLC38A10 solute carrier family 38, member 10
SLC41A3 solute carrier family 41, member 3
SLC4A2 solute carrier family 4 (anion exchanger), member 2
SPSB1 splA/ryanodine receptor domain and SOCS box containing 1
SUSD6 sushi domain containing 6
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1
TEAD3 TEA domain family member 3
TESK2 testis-specific kinase 2
THBS3 thrombospondin 3
TPRA1 transmembrane protein, adipocyte asscociated 1
TRAPPC11 trafficking protein particle complex 11
TRIM28 tripartite motif containing 28
TSPYL2 TSPY-like 2
TTC23 tetratricopeptide repeat domain 23
UBL4A ubiquitin-like 4A
VPS39 vacuolar protein sorting 39 homolog (S. cerevisiae)
VWA1 von Willebrand factor A domain containing 1
WDR76 WD repeat domain 76
ZFP30 ZFP30 zinc finger protein
ZNF268 zinc finger protein 268
ZNF350 zinc finger protein 350
ZNF652 zinc finger protein 652