bendroflumethiazide-3934 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

194 genes differentially expressed following the bendroflumethiazide-3934 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADRA1B adrenoceptor alpha 1B
AEBP1 AE binding protein 1
AFF1 AF4/FMR2 family, member 1
ALDH1B1 aldehyde dehydrogenase 1 family, member B1
ARHGEF28 Rho guanine nucleotide exchange factor (GEF) 28
ASIC4 acid sensing (proton gated) ion channel family member 4
ATP11A ATPase, class VI, type 11A
BNC2 basonuclin 2
C3 complement component 3
C4BPB complement component 4 binding protein, beta
C5AR1 complement component 5a receptor 1
CA9 carbonic anhydrase IX
CASP2 caspase 2, apoptosis-related cysteine peptidase
CCDC70 coiled-coil domain containing 70
CCL16 chemokine (C-C motif) ligand 16
CNKSR2 connector enhancer of kinase suppressor of Ras 2
COL1A1 collagen, type I, alpha 1
COMT catechol-O-methyltransferase
CYP2B7P cytochrome P450, family 2, subfamily B, polypeptide 7, pseudogene
DFNB31 deafness, autosomal recessive 31
DLK2 delta-like 2 homolog (Drosophila)
DRICH1 aspartate-rich 1
EFNB1 ephrin-B1
EMP1 epithelial membrane protein 1
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
ERCC2 excision repair cross-complementation group 2
FAM182B family with sequence similarity 182, member B
FCMR Fc fragment of IgM receptor
FGF16 fibroblast growth factor 16
FGF5 fibroblast growth factor 5
FSHB follicle stimulating hormone, beta polypeptide
FST follistatin
GDPD2 glycerophosphodiester phosphodiesterase domain containing 2
GFI1 growth factor independent 1 transcription repressor
GHRHR growth hormone releasing hormone receptor
GNAO1 guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O
GRIP2 glutamate receptor interacting protein 2
GRM4 glutamate receptor, metabotropic 4
HCLS1 hematopoietic cell-specific Lyn substrate 1
HGD homogentisate 1,2-dioxygenase
HIF3A hypoxia inducible factor 3, alpha subunit
HOXB5 homeobox B5
HSPG2 heparan sulfate proteoglycan 2
HTR6 5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled
ICA1 islet cell autoantigen 1, 69kDa
ICOSLG inducible T-cell co-stimulator ligand
IL22RA1 interleukin 22 receptor, alpha 1
IL36RN interleukin 36 receptor antagonist
INHBE inhibin, beta E
INPP5J inositol polyphosphate-5-phosphatase J
JMJD6 jumonji domain containing 6
KCNA5 potassium channel, voltage gated shaker related subfamily A, member 5
KIR2DS1 killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 1
LAG3 lymphocyte-activation gene 3
LIMK1 LIM domain kinase 1
LOC440895 two pore channel 3 pseudogene
LPAR3 lysophosphatidic acid receptor 3
MEGF6 multiple EGF-like-domains 6
MTSS1 metastasis suppressor 1
NDUFB7 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 7, 18kDa
NEUROG1 neurogenin 1
NMNAT2 nicotinamide nucleotide adenylyltransferase 2
NRP1 neuropilin 1
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
OR2H2 olfactory receptor, family 2, subfamily H, member 2
PIP prolactin-induced protein
PKD1 polycystic kidney disease 1 (autosomal dominant)
PLEKHF1 pleckstrin homology domain containing, family F (with FYVE domain) member 1
PLK3 polo-like kinase 3
PNPLA3 patatin-like phospholipase domain containing 3
PPARD peroxisome proliferator-activated receptor delta
PPP1R12B protein phosphatase 1, regulatory subunit 12B
PPP2R5B protein phosphatase 2, regulatory subunit B', beta
PRKAG2 protein kinase, AMP-activated, gamma 2 non-catalytic subunit
PSAT1 phosphoserine aminotransferase 1
REM1 RAS (RAD and GEM)-like GTP-binding 1
RNASE2 ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin)
SEMA6A sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A
SERHL2 serine hydrolase-like 2
SERPINB13 serpin peptidase inhibitor, clade B (ovalbumin), member 13
SFTPB surfactant protein B
SLC12A4 solute carrier family 12 (potassium/chloride transporter), member 4
SLC39A9 solute carrier family 39, member 9
SLC6A13 solute carrier family 6 (neurotransmitter transporter), member 13
SLC7A7 solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
SOX10 SRY (sex determining region Y)-box 10
SOX2 SRY (sex determining region Y)-box 2
STIM1 stromal interaction molecule 1
SYNDIG1 synapse differentiation inducing 1
TBCD tubulin folding cofactor D
TP63 tumor protein p63
TRIM38 tripartite motif containing 38
UBA6 ubiquitin-like modifier activating enzyme 6
URB1 URB1 ribosome biogenesis 1 homolog (S. cerevisiae)
WNT16 wingless-type MMTV integration site family, member 16
WNT8B wingless-type MMTV integration site family, member 8B
ZC3H7B zinc finger CCCH-type containing 7B

decreased expression

Symbol Name
ABCA7 ATP-binding cassette, sub-family A (ABC1), member 7
ADAM15 ADAM metallopeptidase domain 15
ALOX15 arachidonate 15-lipoxygenase
ALPK1 alpha-kinase 1
ANKRD2 ankyrin repeat domain 2 (stretch responsive muscle)
ATAT1 alpha tubulin acetyltransferase 1
ATP10D ATPase, class V, type 10D
BAHCC1 BAH domain and coiled-coil containing 1
BCO1 beta-carotene oxygenase 1
BMP4 bone morphogenetic protein 4
BTF3P12 basic transcription factor 3 pseudogene 12
C16ORF45 chromosome 16 open reading frame 45
C5AR2 complement component 5a receptor 2
CAMK1 calcium/calmodulin-dependent protein kinase I
CARTPT CART prepropeptide
CD34 CD34 molecule
CD82 CD82 molecule
CDK3 cyclin-dependent kinase 3
CEP295 centrosomal protein 295kDa
CIDEB cell death-inducing DFFA-like effector b
CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
CNTFR ciliary neurotrophic factor receptor
CYP17A1 cytochrome P450, family 17, subfamily A, polypeptide 1
DAGLA diacylglycerol lipase, alpha
DHX35 DEAH (Asp-Glu-Ala-His) box polypeptide 35
DNAJA4 DnaJ (Hsp40) homolog, subfamily A, member 4
DYSF dysferlin
EXD3 exonuclease 3'-5' domain containing 3
EXO5 exonuclease 5
FAM76A family with sequence similarity 76, member A
FBXW4P1 F-box and WD repeat domain containing 4 pseudogene 1
FFAR2 free fatty acid receptor 2
FKBP10 FK506 binding protein 10, 65 kDa
FLJ11710 uncharacterized protein FLJ11710
FOXI1 forkhead box I1
GATA4 GATA binding protein 4
GFPT2 glutamine-fructose-6-phosphate transaminase 2
GNG4 guanine nucleotide binding protein (G protein), gamma 4
GPRC5D G protein-coupled receptor, class C, group 5, member D
HIST1H2AI histone cluster 1, H2ai
HIST1H2BC histone cluster 1, H2bc
HP1BP3 heterochromatin protein 1, binding protein 3
IFNA17 interferon, alpha 17
IL1RAPL2 interleukin 1 receptor accessory protein-like 2
IL4R interleukin 4 receptor
IRF6 interferon regulatory factor 6
ITIH2 inter-alpha-trypsin inhibitor heavy chain 2
JAM3 junctional adhesion molecule 3
KANSL1L KAT8 regulatory NSL complex subunit 1-like
KCNK2 potassium channel, two pore domain subfamily K, member 2
KCNMB1 potassium channel subfamily M regulatory beta subunit 1
KHDRBS3 KH domain containing, RNA binding, signal transduction associated 3
KLF8 Kruppel-like factor 8
LGALS4 lectin, galactoside-binding, soluble, 4
MAPKBP1 mitogen-activated protein kinase binding protein 1
MFGE8 milk fat globule-EGF factor 8 protein
MTA2 metastasis associated 1 family, member 2
MX2 MX dynamin-like GTPase 2
NLGN1 neuroligin 1
NOTCH4 notch 4
NPY4R neuropeptide Y receptor Y4
OR7E156P olfactory receptor, family 7, subfamily E, member 156 pseudogene
PCDHB13 protocadherin beta 13
QPCTL glutaminyl-peptide cyclotransferase-like
RAB30 RAB30, member RAS oncogene family
RAD54L2 RAD54-like 2 (S. cerevisiae)
RHBG Rh family, B glycoprotein (gene/pseudogene)
RHOBTB2 Rho-related BTB domain containing 2
RHPN1-AS1 RHPN1 antisense RNA 1 (head to head)
RIBC2 RIB43A domain with coiled-coils 2
RPL23AP32 ribosomal protein L23a pseudogene 32
SAG S-antigen; retina and pineal gland (arrestin)
SCGB2A2 secretoglobin, family 2A, member 2
SEMA6D sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SLC10A1 solute carrier family 10 (sodium/bile acid cotransporter), member 1
SLC7A9 solute carrier family 7 (amino acid transporter light chain, bo,+ system), member 9
TAS2R10 taste receptor, type 2, member 10
TBC1D19 TBC1 domain family, member 19
TEP1 telomerase-associated protein 1
TESC tescalcin
TLR2 toll-like receptor 2
TM4SF4 transmembrane 4 L six family member 4
TNFRSF8 tumor necrosis factor receptor superfamily, member 8
TOM1 target of myb1 (chicken)
TRPM4 transient receptor potential cation channel, subfamily M, member 4
UBQLN4 ubiquilin 4
USB1 U6 snRNA biogenesis 1
USP19 ubiquitin specific peptidase 19
VAV1 vav 1 guanine nucleotide exchange factor
WDR76 WD repeat domain 76
XDH xanthine dehydrogenase
ZDHHC14 zinc finger, DHHC-type containing 14
ZNF37BP zinc finger protein 37B, pseudogene
ZNF573 zinc finger protein 573
ZNF682 zinc finger protein 682
ZNF747 zinc finger protein 747