benfotiamine-6032 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

197 genes differentially expressed following the benfotiamine-6032 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
A4GNT alpha-1,4-N-acetylglucosaminyltransferase
ADAM12 ADAM metallopeptidase domain 12
ADAM22 ADAM metallopeptidase domain 22
AGAP2 ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
ALOX5 arachidonate 5-lipoxygenase
ALX3 ALX homeobox 3
AMT aminomethyltransferase
ANK1 ankyrin 1, erythrocytic
ARID3B AT rich interactive domain 3B (BRIGHT-like)
ATN1 atrophin 1
BIN1 bridging integrator 1
BIRC7 baculoviral IAP repeat containing 7
BRF1 BRF1, RNA polymerase III transcription initiation factor 90 kDa subunit
BSN bassoon presynaptic cytomatrix protein
BST2 bone marrow stromal cell antigen 2
BTF3P11 basic transcription factor 3 pseudogene 11
C17ORF53 chromosome 17 open reading frame 53
C19ORF66 chromosome 19 open reading frame 66
CA10 carbonic anhydrase X
CACFD1 calcium channel flower domain containing 1
CCPG1 cell cycle progression 1
CD200 CD200 molecule
CD40LG CD40 ligand
CD58 CD58 molecule
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney)
CHD5 chromodomain helicase DNA binding protein 5
CHRNA10 cholinergic receptor, nicotinic, alpha 10 (neuronal)
CLCN7 chloride channel, voltage-sensitive 7
CLEC3B C-type lectin domain family 3, member B
COL13A1 collagen, type XIII, alpha 1
CPB2 carboxypeptidase B2 (plasma)
CPNE7 copine VII
CROCC ciliary rootlet coiled-coil, rootletin
CYP2A7 cytochrome P450, family 2, subfamily A, polypeptide 7
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DOK4 docking protein 4
EBI3 Epstein-Barr virus induced 3
ECE1 endothelin converting enzyme 1
EFS embryonal Fyn-associated substrate
FAM212B family with sequence similarity 212, member B
FAM46C family with sequence similarity 46, member C
FGF9 fibroblast growth factor 9
FLI1 Fli-1 proto-oncogene, ETS transcription factor
FLOT1 flotillin 1
FN1 fibronectin 1
GABRR2 gamma-aminobutyric acid (GABA) A receptor, rho 2
GCNT4 glucosaminyl (N-acetyl) transferase 4, core 2
GNAS GNAS complex locus
GPR37 G protein-coupled receptor 37 (endothelin receptor type B-like)
GRM7 glutamate receptor, metabotropic 7
GSTA3 glutathione S-transferase alpha 3
HOXA11 homeobox A11
HRASLS HRAS-like suppressor
ICOSLG inducible T-cell co-stimulator ligand
JPH3 junctophilin 3
KCNJ15 potassium channel, inwardly rectifying subfamily J, member 15
KEL Kell blood group, metallo-endopeptidase
KIF1C kinesin family member 1C
KIF25-AS1 KIF25 antisense RNA 1
KIR2DS1 killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 1
LHX3 LIM homeobox 3
LYZL6 lysozyme-like 6
MAPK14 mitogen-activated protein kinase 14
MED25 mediator complex subunit 25
MIER2 mesoderm induction early response 1, family member 2
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10
MRPL41 mitochondrial ribosomal protein L41
MS4A1 membrane-spanning 4-domains, subfamily A, member 1
MS4A6A membrane-spanning 4-domains, subfamily A, member 6A
NCAM1 neural cell adhesion molecule 1
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
NTN1 netrin 1
OGDHL oxoglutarate dehydrogenase-like
OR1F2P olfactory receptor, family 1, subfamily F, member 2, pseudogene
PDE10A phosphodiesterase 10A
PDE2A phosphodiesterase 2A, cGMP-stimulated
PML promyelocytic leukemia
POU2F2 POU class 2 homeobox 2
PRDM1 PR domain containing 1, with ZNF domain
RGS5 regulator of G-protein signaling 5
RHEB Ras homolog enriched in brain
RIC3 RIC3 acetylcholine receptor chaperone
SIT1 signaling threshold regulating transmembrane adaptor 1
SLC25A30 solute carrier family 25, member 30
SLC35D1 solute carrier family 35 (UDP-GlcA/UDP-GalNAc transporter), member D1
SLC6A16 solute carrier family 6, member 16
SLC9A7 solute carrier family 9, subfamily A (NHE7, cation proton antiporter 7), member 7
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SNCAIP synuclein, alpha interacting protein
SPOCK2 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2
STK24 serine/threonine kinase 24
TAOK2 TAO kinase 2
TBL1Y transducin (beta)-like 1, Y-linked
TRIM15 tripartite motif containing 15
TTC38 tetratricopeptide repeat domain 38
UNC5B unc-5 homolog B (C. elegans)
UPK3A uroplakin 3A
WDR55 WD repeat domain 55
ZNF446 zinc finger protein 446

decreased expression

Symbol Name
ACTL8 actin-like 8
ADGRE5 adhesion G protein-coupled receptor E5
ADM adrenomedullin
AES amino-terminal enhancer of split
ALPK1 alpha-kinase 1
ANKRD36 ankyrin repeat domain 36
ANP32A-IT1 ANP32A intronic transcript 1
APBB3 amyloid beta (A4) precursor protein-binding, family B, member 3
ATP7A ATPase, Cu++ transporting, alpha polypeptide
AUTS2 autism susceptibility candidate 2
B3GNT3 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3
C14ORF93 chromosome 14 open reading frame 93
C1QTNF3 C1q and tumor necrosis factor related protein 3
C22ORF29 chromosome 22 open reading frame 29
CAPG capping protein (actin filament), gelsolin-like
CAPRIN2 caprin family member 2
CCBL1 cysteine conjugate-beta lyase, cytoplasmic
CHST10 carbohydrate sulfotransferase 10
CHST8 carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8
CRYBB2P1 crystallin, beta B2 pseudogene 1
CXORF56 chromosome X open reading frame 56
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha
DYSF dysferlin
EHMT1 euchromatic histone-lysine N-methyltransferase 1
ELOVL4 ELOVL fatty acid elongase 4
FAN1 FANCD2/FANCI-associated nuclease 1
FILIP1L filamin A interacting protein 1-like
FKBP1B FK506 binding protein 1B, 12.6 kDa
FLCN folliculin
FMO4 flavin containing monooxygenase 4
FMOD fibromodulin
FOSL1 FOS-like antigen 1
FOXN2 forkhead box N2
GABRB2 gamma-aminobutyric acid (GABA) A receptor, beta 2
GADD45G growth arrest and DNA-damage-inducible, gamma
GATA4 GATA binding protein 4
GLS2 glutaminase 2 (liver, mitochondrial)
GNG4 guanine nucleotide binding protein (G protein), gamma 4
GPR19 G protein-coupled receptor 19
GRB7 growth factor receptor-bound protein 7
GRPR gastrin-releasing peptide receptor
GSTCD glutathione S-transferase, C-terminal domain containing
HOXA4 homeobox A4
HOXC5 homeobox C5
IFITM1 interferon induced transmembrane protein 1
INO80D INO80 complex subunit D
IQSEC2 IQ motif and Sec7 domain 2
JMJD4 jumonji domain containing 4
KIAA0319L KIAA0319-like
LMO2 LIM domain only 2 (rhombotin-like 1)
LRP5L low density lipoprotein receptor-related protein 5-like
LY6D lymphocyte antigen 6 complex, locus D
MALL mal, T-cell differentiation protein-like
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase
MID1IP1 MID1 interacting protein 1
MINOS1P1 mitochondrial inner membrane organizing system 1 pseudogene 1
MXD3 MAX dimerization protein 3
MYO1E myosin IE
NDE1 nudE neurodevelopment protein 1
NPIPB15 nuclear pore complex interacting protein family, member B15
NPIPB3 nuclear pore complex interacting protein family, member B3
PLEKHG6 pleckstrin homology domain containing, family G (with RhoGef domain) member 6
PLEKHO2 pleckstrin homology domain containing, family O member 2
POLL polymerase (DNA directed), lambda
POMT2 protein-O-mannosyltransferase 2
POR P450 (cytochrome) oxidoreductase
PQLC2 PQ loop repeat containing 2
PTPN13 protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)
R3HCC1L R3H domain and coiled-coil containing 1-like
RAB3IL1 RAB3A interacting protein (rabin3)-like 1
RGS2 regulator of G-protein signaling 2
RHOBTB2 Rho-related BTB domain containing 2
RNF2 ring finger protein 2
SETD8 SET domain containing (lysine methyltransferase) 8
SHARPIN SHANK-associated RH domain interactor
SLIT2 slit homolog 2 (Drosophila)
SNAPC2 small nuclear RNA activating complex, polypeptide 2, 45kDa
SND1-IT1 SND1 intronic transcript 1
SPAG4 sperm associated antigen 4
SPSB1 splA/ryanodine receptor domain and SOCS box containing 1
SUSD4 sushi domain containing 4
TBC1D17 TBC1 domain family, member 17
TESC tescalcin
THBS3 thrombospondin 3
TICAM1 toll-like receptor adaptor molecule 1
TRDMT1 tRNA aspartic acid methyltransferase 1
UBTD1 ubiquitin domain containing 1
UNC119 unc-119 homolog (C. elegans)
USP27X ubiquitin specific peptidase 27, X-linked
VPS9D1 VPS9 domain containing 1
WDR33 WD repeat domain 33
ZBTB48 zinc finger and BTB domain containing 48
ZDHHC11 zinc finger, DHHC-type containing 11
ZKSCAN3 zinc finger with KRAB and SCAN domains 3
ZNF286A zinc finger protein 286A
ZNF324 zinc finger protein 324
ZNF552 zinc finger protein 552
ZNF770 zinc finger protein 770