benzthiazide-2989 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

197 genes differentially expressed following the benzthiazide-2989 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
A4GALT alpha 1,4-galactosyltransferase
ADRB1 adrenoceptor beta 1
AKT2 v-akt murine thymoma viral oncogene homolog 2
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
AP4E1 adaptor-related protein complex 4, epsilon 1 subunit
APPBP2 amyloid beta precursor protein (cytoplasmic tail) binding protein 2
ATP9A ATPase, class II, type 9A
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BRF1 BRF1, RNA polymerase III transcription initiation factor 90 kDa subunit
CD160 CD160 molecule
CD177 CD177 molecule
CD22 CD22 molecule
CD84 CD84 molecule
CDC42 cell division cycle 42
CFP complement factor properdin
CHMP6 charged multivesicular body protein 6
CNTFR ciliary neurotrophic factor receptor
CTDSPL CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like
DDAH2 dimethylarginine dimethylaminohydrolase 2
DESI2 desumoylating isopeptidase 2
DGKI diacylglycerol kinase, iota
DNAH3 dynein, axonemal, heavy chain 3
DNAI2 dynein, axonemal, intermediate chain 2
DNAJB12 DnaJ (Hsp40) homolog, subfamily B, member 12
DPT dermatopontin
DPY19L1P1 DPY19L1 pseudogene 1
EFR3B EFR3 homolog B (S. cerevisiae)
EGOT eosinophil granule ontogeny transcript (non-protein coding)
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
FGF18 fibroblast growth factor 18
FOXO4 forkhead box O4
GAS8 growth arrest-specific 8
GPATCH4 G patch domain containing 4
GRM4 glutamate receptor, metabotropic 4
GSN-AS1 GSN antisense RNA 1
H1F0 H1 histone family, member 0
HAO2 hydroxyacid oxidase 2 (long chain)
HES1 hes family bHLH transcription factor 1
HIPK3 homeodomain interacting protein kinase 3
HIST1H2BC histone cluster 1, H2bc
HIST2H2AA3 histone cluster 2, H2aa3
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HOXB3 homeobox B3
HRASLS2 HRAS-like suppressor 2
IFNA21 interferon, alpha 21
ITGA2B integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)
KIAA0125 KIAA0125
KLK5 kallikrein-related peptidase 5
LCMT2 leucine carboxyl methyltransferase 2
LIMD2 LIM domain containing 2
MASP1 mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor)
MBOAT2 membrane bound O-acyltransferase domain containing 2
MCTP2 multiple C2 domains, transmembrane 2
MED14 mediator complex subunit 14
MFAP3L microfibrillar-associated protein 3-like
MIR22HG MIR22 host gene
MOXD1 monooxygenase, DBH-like 1
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
NBR2 neighbor of BRCA1 gene 2 (non-protein coding)
OR2B2 olfactory receptor, family 2, subfamily B, member 2
PBX2 pre-B-cell leukemia homeobox 2
PCSK5 proprotein convertase subtilisin/kexin type 5
PDX1 pancreatic and duodenal homeobox 1
PLN phospholamban
POLR2L polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa
PPP5C protein phosphatase 5, catalytic subunit
PRB4 proline-rich protein BstNI subfamily 4
PTGDS prostaglandin D2 synthase 21kDa (brain)
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8
REM1 RAS (RAD and GEM)-like GTP-binding 1
RHBDF1 rhomboid 5 homolog 1 (Drosophila)
RPL23AP53 ribosomal protein L23a pseudogene 53
SEMG2 semenogelin II
SIGLEC1 sialic acid binding Ig-like lectin 1, sialoadhesin
SLC17A7 solute carrier family 17 (vesicular glutamate transporter), member 7
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SLC7A8 solute carrier family 7 (amino acid transporter light chain, L system), member 8
SLCO2A1 solute carrier organic anion transporter family, member 2A1
SNAPC2 small nuclear RNA activating complex, polypeptide 2, 45kDa
SNX13 sorting nexin 13
SRRM2 serine/arginine repetitive matrix 2
STK3 serine/threonine kinase 3
SULF1 sulfatase 1
SWAP70 SWAP switching B-cell complex 70kDa subunit
SYN2 synapsin II
TAS2R14 taste receptor, type 2, member 14
TEAD3 TEA domain family member 3
TEF thyrotrophic embryonic factor
TFF2 trefoil factor 2
TM4SF1 transmembrane 4 L six family member 1
TMEM63A transmembrane protein 63A
TNFRSF9 tumor necrosis factor receptor superfamily, member 9
TNFSF18 tumor necrosis factor (ligand) superfamily, member 18
TPM3 tropomyosin 3
TRPS1 trichorhinophalangeal syndrome I
WNT16 wingless-type MMTV integration site family, member 16
WWTR1 WW domain containing transcription regulator 1
ZNF34 zinc finger protein 34

decreased expression

Symbol Name
ABHD4 abhydrolase domain containing 4
ADAM15 ADAM metallopeptidase domain 15
ADGB androglobin
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AP5S1 adaptor-related protein complex 5, sigma 1 subunit
APBB3 amyloid beta (A4) precursor protein-binding, family B, member 3
BEST1 bestrophin 1
BHMT2 betaine--homocysteine S-methyltransferase 2
BTBD18 BTB (POZ) domain containing 18
CACNB4 calcium channel, voltage-dependent, beta 4 subunit
CD9 CD9 molecule
CDK20 cyclin-dependent kinase 20
CNN1 calponin 1, basic, smooth muscle
COPG2IT1 COPG2 imprinted transcript 1 (non-protein coding)
COQ6 coenzyme Q6 monooxygenase
CTAGE9 CTAGE family, member 9
CXCL2 chemokine (C-X-C motif) ligand 2
CYP2W1 cytochrome P450, family 2, subfamily W, polypeptide 1
CYP7B1 cytochrome P450, family 7, subfamily B, polypeptide 1
DAGLA diacylglycerol lipase, alpha
DSCAM Down syndrome cell adhesion molecule
EBF2 early B-cell factor 2
ERCC4 excision repair cross-complementation group 4
FAM106A family with sequence similarity 106, member A
FBXL7 F-box and leucine-rich repeat protein 7
FCGR1A Fc fragment of IgG, high affinity Ia, receptor (CD64)
FRMPD1 FERM and PDZ domain containing 1
GNRH1 gonadotropin-releasing hormone 1 (luteinizing-releasing hormone)
GPATCH2L G patch domain containing 2-like
GPR35 G protein-coupled receptor 35
GRPR gastrin-releasing peptide receptor
HDAC7 histone deacetylase 7
HIST1H3I histone cluster 1, H3i
HOXC10 homeobox C10
HOXD10 homeobox D10
HSPA1L heat shock 70kDa protein 1-like
IBSP integrin-binding sialoprotein
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IFT140 intraflagellar transport 140
IFT22 intraflagellar transport 22
ITGA10 integrin, alpha 10
JAM3 junctional adhesion molecule 3
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
KIAA1107 KIAA1107
KLK11 kallikrein-related peptidase 11
KPTN kaptin (actin binding protein)
KRT12 keratin 12, type I
LIN7A lin-7 homolog A (C. elegans)
LINC00260 long intergenic non-protein coding RNA 260
LOC57399 uncharacterized gastric protein ZA52P
LY6D lymphocyte antigen 6 complex, locus D
MMP9 matrix metallopeptidase 9
MUC2 mucin 2, oligomeric mucus/gel-forming
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
MYH15 myosin, heavy chain 15
N4BP2L2-IT2 N4BPL2 intronic transcript 2
NCS1 neuronal calcium sensor 1
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
NOD1 nucleotide-binding oligomerization domain containing 1
NPFFR1 neuropeptide FF receptor 1
NPPB natriuretic peptide B
PAK1 p21 protein (Cdc42/Rac)-activated kinase 1
PCBP4 poly(rC) binding protein 4
PELP1 proline, glutamate and leucine rich protein 1
PFN2 profilin 2
PLAT plasminogen activator, tissue
PLEKHS1 pleckstrin homology domain containing, family S member 1
PMFBP1 polyamine modulated factor 1 binding protein 1
PPCDC phosphopantothenoylcysteine decarboxylase
PPT2 palmitoyl-protein thioesterase 2
PRR7 proline rich 7 (synaptic)
RAB17 RAB17, member RAS oncogene family
RAB3A RAB3A, member RAS oncogene family
RAB3IL1 RAB3A interacting protein (rabin3)-like 1
SCRT1 scratch family zinc finger 1
SFRP5 secreted frizzled-related protein 5
SIGLEC15 sialic acid binding Ig-like lectin 15
SIX3 SIX homeobox 3
SLC16A4 solute carrier family 16, member 4
SLC25A10 solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 10
SLITRK5 SLIT and NTRK-like family, member 5
SMR3B submaxillary gland androgen regulated protein 3B
STAG3L4 stromal antigen 3-like 4 (pseudogene)
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2
TBXAS1 thromboxane A synthase 1 (platelet)
TCTN2 tectonic family member 2
TESK1 testis-specific kinase 1
TFDP3 transcription factor Dp family, member 3
THEM6 thioesterase superfamily member 6
TIAM2 T-cell lymphoma invasion and metastasis 2
TOM1 target of myb1 (chicken)
TRPC5 transient receptor potential cation channel, subfamily C, member 5
VWA1 von Willebrand factor A domain containing 1
ZNF177 zinc finger protein 177
ZNF280A zinc finger protein 280A
ZNF385D zinc finger protein 385D
ZNF408 zinc finger protein 408
ZNF675 zinc finger protein 675