benzthiazide-6607 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

198 genes differentially expressed following the benzthiazide-6607 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
A1CF APOBEC1 complementation factor
ADAP1 ArfGAP with dual PH domains 1
ADGRE3 adhesion G protein-coupled receptor E3
APBB1 amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2
ASAP3 ArfGAP with SH3 domain, ankyrin repeat and PH domain 3
ATAT1 alpha tubulin acetyltransferase 1
BACH1 BTB and CNC homology 1, basic leucine zipper transcription factor 1
BATF basic leucine zipper transcription factor, ATF-like
BGN biglycan
BMP5 bone morphogenetic protein 5
CBFA2T3 core-binding factor, runt domain, alpha subunit 2; translocated to, 3
CCL5 chemokine (C-C motif) ligand 5
CD6 CD6 molecule
CD93 CD93 molecule
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CNPY4 canopy FGF signaling regulator 4
CYP2C9 cytochrome P450, family 2, subfamily C, polypeptide 9
DAPK2 death-associated protein kinase 2
DKKL1 dickkopf-like 1
EDA ectodysplasin A
EML2 echinoderm microtubule associated protein like 2
EYA3 EYA transcriptional coactivator and phosphatase 3
FABP3 fatty acid binding protein 3, muscle and heart
FCER1A Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide
FOXRED2 FAD-dependent oxidoreductase domain containing 2
FRMD4B FERM domain containing 4B
FRMD8 FERM domain containing 8
FUBP1 far upstream element (FUSE) binding protein 1
GFI1 growth factor independent 1 transcription repressor
GK glycerol kinase
GP1BA glycoprotein Ib (platelet), alpha polypeptide
GPLD1 glycosylphosphatidylinositol specific phospholipase D1
GUCY1A2 guanylate cyclase 1, soluble, alpha 2
HIP1 huntingtin interacting protein 1
HIRA histone cell cycle regulator
ICOS inducible T-cell co-stimulator
IFT54 intraflagellar transport 54
IL22 interleukin 22
IL2RG interleukin 2 receptor, gamma
INHBC inhibin, beta C
KCNAB1 potassium channel, voltage gated subfamily A regulatory beta subunit 1
KCNJ15 potassium channel, inwardly rectifying subfamily J, member 15
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
KLHL24 kelch-like family member 24
KLHL25 kelch-like family member 25
LAMA2 laminin, alpha 2
LILRB3 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3
LINC00260 long intergenic non-protein coding RNA 260
LOC157562 uncharacterized LOC157562
LOC202181 SUMO-interacting motifs containing 1 pseudogene
LRRC17 leucine rich repeat containing 17
LRRK1 leucine-rich repeat kinase 1
MBNL1 muscleblind-like splicing regulator 1
MFAP3L microfibrillar-associated protein 3-like
MIER2 mesoderm induction early response 1, family member 2
MINOS1P1 mitochondrial inner membrane organizing system 1 pseudogene 1
MS4A6A membrane-spanning 4-domains, subfamily A, member 6A
N4BP2L1 NEDD4 binding protein 2-like 1
NID2 nidogen 2 (osteonidogen)
NMT2 N-myristoyltransferase 2
PADI2 peptidyl arginine deiminase, type II
PALM paralemmin
PARP6 poly (ADP-ribose) polymerase family, member 6
PAX2 paired box 2
PAX8 paired box 8
PDE11A phosphodiesterase 11A
PDE4DIP phosphodiesterase 4D interacting protein
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha
PLXNB1 plexin B1
PODNL1 podocan-like 1
PROL1 proline rich, lacrimal 1
PSTPIP2 proline-serine-threonine phosphatase interacting protein 2
PTGDS prostaglandin D2 synthase 21kDa (brain)
PTN pleiotrophin
PTPRB protein tyrosine phosphatase, receptor type, B
RAD23B RAD23 homolog B (S. cerevisiae)
RAG2 recombination activating gene 2
RASSF4 Ras association (RalGDS/AF-6) domain family member 4
RIMS2 regulating synaptic membrane exocytosis 2
RND2 Rho family GTPase 2
RPLP2 ribosomal protein, large, P2
SGCD sarcoglycan, delta (35kDa dystrophin-associated glycoprotein)
SMG7 SMG7 nonsense mediated mRNA decay factor
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1)
SORBS2 sorbin and SH3 domain containing 2
SOS2 son of sevenless homolog 2 (Drosophila)
SPOCK2 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2
STS steroid sulfatase (microsomal), isozyme S
TAPBPL TAP binding protein-like
TCF4 transcription factor 4
TEX13A testis expressed 13A
THBD thrombomodulin
TIAM2 T-cell lymphoma invasion and metastasis 2
TJP3 tight junction protein 3
TNKS2 tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2
TRIM15 tripartite motif containing 15
ZC3H7B zinc finger CCCH-type containing 7B
ZFP64 ZFP64 zinc finger protein

decreased expression

Symbol Name
ABHD17B abhydrolase domain containing 17B
ADRB2 adrenoceptor beta 2, surface
AFF4 AF4/FMR2 family, member 4
AOC2 amine oxidase, copper containing 2 (retina-specific)
AP4M1 adaptor-related protein complex 4, mu 1 subunit
ARHGAP12 Rho GTPase activating protein 12
ARHGEF16 Rho guanine nucleotide exchange factor (GEF) 16
BOLA1 bolA family member 1
BSG basigin (Ok blood group)
C11ORF63 chromosome 11 open reading frame 63
C17ORF75 chromosome 17 open reading frame 75
C5ORF42 chromosome 5 open reading frame 42
CAMK1 calcium/calmodulin-dependent protein kinase I
CAMKMT calmodulin-lysine N-methyltransferase
CCT6B chaperonin containing TCP1, subunit 6B (zeta 2)
CDKN2D cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)
CLDN15 claudin 15
CYBRD1 cytochrome b reductase 1
CYP26B1 cytochrome P450, family 26, subfamily B, polypeptide 1
DCBLD2 discoidin, CUB and LCCL domain containing 2
DDN dendrin
DNAL4 dynein, axonemal, light chain 4
EHF ets homologous factor
EMP3 epithelial membrane protein 3
ERCC4 excision repair cross-complementation group 4
FAM184A family with sequence similarity 184, member A
FBXL7 F-box and leucine-rich repeat protein 7
FNTB farnesyltransferase, CAAX box, beta
FZD8 frizzled class receptor 8
GABRR2 gamma-aminobutyric acid (GABA) A receptor, rho 2
GEMIN8 gem (nuclear organelle) associated protein 8
GFPT2 glutamine-fructose-6-phosphate transaminase 2
GNA13 guanine nucleotide binding protein (G protein), alpha 13
GNAZ guanine nucleotide binding protein (G protein), alpha z polypeptide
GPR1 G protein-coupled receptor 1
GTF2I general transcription factor IIi
HIST1H2AJ histone cluster 1, H2aj
HIST1H2AK histone cluster 1, H2ak
HIST1H3G histone cluster 1, H3g
HIST1H4E histone cluster 1, H4e
HSPA1L heat shock 70kDa protein 1-like
IDI2-AS1 IDI2 antisense RNA 1
INO80D INO80 complex subunit D
IPO8 importin 8
KCNS3 potassium voltage-gated channel, modifier subfamily S, member 3
KDM7A lysine (K)-specific demethylase 7A
KIAA0319L KIAA0319-like
KRT6A keratin 6A, type II
LSM14B LSM14B, SCD6 homolog B (S. cerevisiae)
MAP3K2 mitogen-activated protein kinase kinase kinase 2
MAPK12 mitogen-activated protein kinase 12
MDM4 MDM4, p53 regulator
METTL16 methyltransferase like 16
MFSD12 major facilitator superfamily domain containing 12
MOCS3 molybdenum cofactor synthesis 3
NDE1 nudE neurodevelopment protein 1
NFKBIL1 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1
NR1H3 nuclear receptor subfamily 1, group H, member 3
NUDT6 nudix (nucleoside diphosphate linked moiety X)-type motif 6
NUS1P3 nuclear undecaprenyl pyrophosphate synthase 1 homolog (S. cerevisiae) pseudogene 3
OSMR oncostatin M receptor
PARM1 prostate androgen-regulated mucin-like protein 1
PCOLCE procollagen C-endopeptidase enhancer
PDE6B phosphodiesterase 6B, cGMP-specific, rod, beta
PDE6C phosphodiesterase 6C, cGMP-specific, cone, alpha prime
PDGFRL platelet-derived growth factor receptor-like
PRR7 proline rich 7 (synaptic)
PRSS8 protease, serine, 8
R3HCC1L R3H domain and coiled-coil containing 1-like
RAP1GAP2 RAP1 GTPase activating protein 2
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8
REM1 RAS (RAD and GEM)-like GTP-binding 1
RNF39 ring finger protein 39
RPGRIP1L RPGRIP1-like
SAYSD1 SAYSVFN motif domain containing 1
SERPIND1 serpin peptidase inhibitor, clade D (heparin cofactor), member 1
SLC17A5 solute carrier family 17 (acidic sugar transporter), member 5
SLC9A2 solute carrier family 9, subfamily A (NHE2, cation proton antiporter 2), member 2
SMEK2 SMEK homolog 2, suppressor of mek1 (Dictyostelium)
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase
STAG3 stromal antigen 3
STARD5 StAR-related lipid transfer (START) domain containing 5
SYNPO synaptopodin
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa
TAGLN3 transgelin 3
TBC1D19 TBC1 domain family, member 19
THBS3 thrombospondin 3
TMEM177 transmembrane protein 177
TNFSF12 tumor necrosis factor (ligand) superfamily, member 12
TUBA3C tubulin, alpha 3c
USP27X ubiquitin specific peptidase 27, X-linked
WDR62 WD repeat domain 62
ZFP30 ZFP30 zinc finger protein
ZNF10 zinc finger protein 10
ZNF107 zinc finger protein 107
ZNF141 zinc finger protein 141
ZNF428 zinc finger protein 428
ZNF675 zinc finger protein 675
ZNF816 zinc finger protein 816