bepridil-5674 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

198 genes differentially expressed following the bepridil-5674 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADM adrenomedullin
ALPPL2 alkaline phosphatase, placental-like 2
ATF3 activating transcription factor 3
CCNA1 cyclin A1
CD163 CD163 molecule
CDK2 cyclin-dependent kinase 2
CELF2 CUGBP, Elav-like family member 2
CEP250 centrosomal protein 250kDa
CSHL1 chorionic somatomammotropin hormone-like 1
CXCR4 chemokine (C-X-C motif) receptor 4
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DIRAS3 DIRAS family, GTP-binding RAS-like 3
DNAJB12 DnaJ (Hsp40) homolog, subfamily B, member 12
DSCAM Down syndrome cell adhesion molecule
EGR1 early growth response 1
EGR4 early growth response 4
ELL2 elongation factor, RNA polymerase II, 2
FAM46C family with sequence similarity 46, member C
FGFR3 fibroblast growth factor receptor 3
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
GAD2 glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)
GEM GTP binding protein overexpressed in skeletal muscle
GLDC glycine dehydrogenase (decarboxylating)
HIF3A hypoxia inducible factor 3, alpha subunit
HRH1 histamine receptor H1
ICAM1 intercellular adhesion molecule 1
ICAM2 intercellular adhesion molecule 2
IER2 immediate early response 2
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IFIT2 interferon-induced protein with tetratricopeptide repeats 2
IFIT3 interferon-induced protein with tetratricopeptide repeats 3
IFNA16 interferon, alpha 16
IGKV1D-13 immunoglobulin kappa variable 1D-13
INHBE inhibin, beta E
IRF1 interferon regulatory factor 1
IRS2 insulin receptor substrate 2
JUN jun proto-oncogene
KCND1 potassium channel, voltage gated Shal related subfamily D, member 1
KCNJ5 potassium channel, inwardly rectifying subfamily J, member 5
KIR2DS2 killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 2
KLF2 Kruppel-like factor 2
KLF6 Kruppel-like factor 6
KLHL24 kelch-like family member 24
LIF leukemia inhibitory factor
LOXL3 lysyl oxidase-like 3
LPIN1 lipin 1
LY96 lymphocyte antigen 96
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2
MBL1P mannose-binding lectin (protein A) 1, pseudogene
MT1F metallothionein 1F
NCAM1 neural cell adhesion molecule 1
NFX1 nuclear transcription factor, X-box binding 1
NIPSNAP3B nipsnap homolog 3B (C. elegans)
NOL12 nucleolar protein 12
NPY6R neuropeptide Y receptor Y6 (pseudogene)
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NR4A3 nuclear receptor subfamily 4, group A, member 3
NR5A2 nuclear receptor subfamily 5, group A, member 2
NUP50 nucleoporin 50kDa
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa
OASL 2'-5'-oligoadenylate synthetase-like
OSGIN1 oxidative stress induced growth inhibitor 1
PCDHB12 protocadherin beta 12
PHLDA1 pleckstrin homology-like domain, family A, member 1
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PLEK pleckstrin
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PTCRA pre T-cell antigen receptor alpha
RGS5 regulator of G-protein signaling 5
RND1 Rho family GTPase 1
RNF17 ring finger protein 17
RQCD1 RCD1 required for cell differentiation1 homolog (S. pombe)
RUNX1 runt-related transcription factor 1
SLC17A7 solute carrier family 17 (vesicular glutamate transporter), member 7
SLC34A2 solute carrier family 34 (type II sodium/phosphate cotransporter), member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SOX9 SRY (sex determining region Y)-box 9
SRCAP Snf2-related CREBBP activator protein
STS steroid sulfatase (microsomal), isozyme S
TBX10 T-box 10
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
TOX3 TOX high mobility group box family member 3
TP63 tumor protein p63
UBXN1 UBX domain protein 1
VIPR1 vasoactive intestinal peptide receptor 1
VPRBP Vpr (HIV-1) binding protein
WIZ widely interspaced zinc finger motifs
YPEL1 yippee-like 1 (Drosophila)
ZNF419 zinc finger protein 419
ZNF442 zinc finger protein 442
ZZEF1 zinc finger, ZZ-type with EF-hand domain 1

decreased expression

Symbol Name
ACTL8 actin-like 8
ACTR3B ARP3 actin-related protein 3 homolog B (yeast)
ADGRG2 adhesion G protein-coupled receptor G2
AFAP1 actin filament associated protein 1
ALKBH4 alkB, alkylation repair homolog 4 (E. coli)
ALS2CL ALS2 C-terminal like
AP1S1 adaptor-related protein complex 1, sigma 1 subunit
ARRB1 arrestin, beta 1
ARSB arylsulfatase B
ASTN2 astrotactin 2
ATP8B2 ATPase, aminophospholipid transporter, class I, type 8B, member 2
BAHCC1 BAH domain and coiled-coil containing 1
BCL11B B-cell CLL/lymphoma 11B (zinc finger protein)
BPGM 2,3-bisphosphoglycerate mutase
C19ORF40 chromosome 19 open reading frame 40
C5ORF45 chromosome 5 open reading frame 45
C9ORF40 chromosome 9 open reading frame 40
CAPN5 calpain 5
CARD8 caspase recruitment domain family, member 8
CASS4 Cas scaffolding protein family member 4
CCBL1 cysteine conjugate-beta lyase, cytoplasmic
CDK3 cyclin-dependent kinase 3
CHST12 carbohydrate (chondroitin 4) sulfotransferase 12
CTDP1 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1
CYP26A1 cytochrome P450, family 26, subfamily A, polypeptide 1
DGAT1 diacylglycerol O-acyltransferase 1
DGKE diacylglycerol kinase, epsilon 64kDa
EAF2 ELL associated factor 2
EDAR ectodysplasin A receptor
EFHD2 EF-hand domain family, member D2
EHHADH enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase
FAM188A family with sequence similarity 188, member A
FAM53B family with sequence similarity 53, member B
FLCN folliculin
FOXRED2 FAD-dependent oxidoreductase domain containing 2
FSTL3 follistatin-like 3 (secreted glycoprotein)
GNL3LP1 guanine nucleotide binding protein-like 3 (nucleolar)-like pseudogene 1
GRTP1 growth hormone regulated TBC protein 1
GUSBP3 glucuronidase, beta pseudogene 3
HEATR3 HEAT repeat containing 3
HIRA histone cell cycle regulator
HIST1H2AJ histone cluster 1, H2aj
HPS6 Hermansky-Pudlak syndrome 6
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
L2HGDH L-2-hydroxyglutarate dehydrogenase
LAIR2 leukocyte-associated immunoglobulin-like receptor 2
LOC202181 SUMO-interacting motifs containing 1 pseudogene
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
LRRC20 leucine rich repeat containing 20
LRRC37A3 leucine rich repeat containing 37, member A3
MAGOH2P mago-nashi homolog 2, pseudogene
MAP3K6 mitogen-activated protein kinase kinase kinase 6
MATK megakaryocyte-associated tyrosine kinase
MBNL3 muscleblind-like splicing regulator 3
METTL2B methyltransferase like 2B
MGC12488
MRPL52 mitochondrial ribosomal protein L52
OLFML2A olfactomedin-like 2A
PARP16 poly (ADP-ribose) polymerase family, member 16
PC pyruvate carboxylase
PDPR pyruvate dehydrogenase phosphatase regulatory subunit
PGBD5 piggyBac transposable element derived 5
PHC1 polyhomeotic homolog 1 (Drosophila)
PIM2 Pim-2 proto-oncogene, serine/threonine kinase
PIP5K1C phosphatidylinositol-4-phosphate 5-kinase, type I, gamma
PLD3 phospholipase D family, member 3
PODNL1 podocan-like 1
POM121 POM121 transmembrane nucleoporin
PTPRE protein tyrosine phosphatase, receptor type, E
RAD54L2 RAD54-like 2 (S. cerevisiae)
RALGPS2 Ral GEF with PH domain and SH3 binding motif 2
RBL1 retinoblastoma-like 1
REM1 RAS (RAD and GEM)-like GTP-binding 1
RIN2 Ras and Rab interactor 2
RNPEPL1 arginyl aminopeptidase (aminopeptidase B)-like 1
RPRM reprimo, TP53 dependent G2 arrest mediator candidate
SLC12A5 solute carrier family 12 (potassium/chloride transporter), member 5
SLC25A21 solute carrier family 25 (mitochondrial oxoadipate carrier), member 21
SLC29A3 solute carrier family 29 (equilibrative nucleoside transporter), member 3
SLMO1 slowmo homolog 1 (Drosophila)
SMEK2 SMEK homolog 2, suppressor of mek1 (Dictyostelium)
SPINK5 serine peptidase inhibitor, Kazal type 5
SPTLC3 serine palmitoyltransferase, long chain base subunit 3
SRPX sushi-repeat containing protein, X-linked
STIM1 stromal interaction molecule 1
SUPT5H suppressor of Ty 5 homolog (S. cerevisiae)
TIMM50 translocase of inner mitochondrial membrane 50 homolog (S. cerevisiae)
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TMEM180 transmembrane protein 180
TMEM209 transmembrane protein 209
TRAIP TRAF interacting protein
UBQLN4 ubiquilin 4
WDR76 WD repeat domain 76
ZNF10 zinc finger protein 10
ZNF16 zinc finger protein 16
ZNF211 zinc finger protein 211
ZNF226 zinc finger protein 226
ZNF286A zinc finger protein 286A
ZNF74 zinc finger protein 74
ZSCAN26 zinc finger and SCAN domain containing 26