berberine-2770 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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196 genes differentially expressed following the berberine-2770 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADGRL1 adhesion G protein-coupled receptor L1
ARAP1 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
ARHGEF17 Rho guanine nucleotide exchange factor (GEF) 17
ATP2C2 ATPase, Ca++ transporting, type 2C, member 2
ATP6V1G2 ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G2
BCL2L10 BCL2-like 10 (apoptosis facilitator)
BTF3P12 basic transcription factor 3 pseudogene 12
CACNA1I calcium channel, voltage-dependent, T type, alpha 1I subunit
CACNG4 calcium channel, voltage-dependent, gamma subunit 4
CAPN5 calpain 5
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
COL5A1 collagen, type V, alpha 1
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
CRMP1 collapsin response mediator protein 1
CSHL1 chorionic somatomammotropin hormone-like 1
CXXC4 CXXC finger protein 4
DAGLA diacylglycerol lipase, alpha
DDIT4 DNA-damage-inducible transcript 4
DYNC1LI2 dynein, cytoplasmic 1, light intermediate chain 2
E2F5 E2F transcription factor 5, p130-binding
ECE1 endothelin converting enzyme 1
EFEMP2 EGF containing fibulin-like extracellular matrix protein 2
EPHB6 EPH receptor B6
FBLN1 fibulin 1
FKBP8 FK506 binding protein 8, 38kDa
FRAS1 Fraser extracellular matrix complex subunit 1
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila)
HAP1 huntingtin-associated protein 1
HMGA1 high mobility group AT-hook 1
HOXA11 homeobox A11
IDS iduronate 2-sulfatase
IGHM immunoglobulin heavy constant mu
IL12RB1 interleukin 12 receptor, beta 1
INHBE inhibin, beta E
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)
KDM5A lysine (K)-specific demethylase 5A
KHSRP KH-type splicing regulatory protein
KLRG1 killer cell lectin-like receptor subfamily G, member 1
LOC100286895 cell division cycle 27 homolog pseudogene
LOC729164 hCG1732469
LRP4 low density lipoprotein receptor-related protein 4
LRRC23 leucine rich repeat containing 23
MAP2K5 mitogen-activated protein kinase kinase 5
MAPK14 mitogen-activated protein kinase 14
MARK2 MAP/microtubule affinity-regulating kinase 2
MBTD1 mbt domain containing 1
MIER2 mesoderm induction early response 1, family member 2
MYL10 myosin, light chain 10, regulatory
MZF1 myeloid zinc finger 1
NF2 neurofibromin 2 (merlin)
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
NR2C1 nuclear receptor subfamily 2, group C, member 1
NR4A1 nuclear receptor subfamily 4, group A, member 1
PAFAH2 platelet-activating factor acetylhydrolase 2, 40kDa
PCDHA5 protocadherin alpha 5
PCSK6 proprotein convertase subtilisin/kexin type 6
PGAP3 post-GPI attachment to proteins 3
PHF20 PHD finger protein 20
PKD1 polycystic kidney disease 1 (autosomal dominant)
PLEKHF1 pleckstrin homology domain containing, family F (with FYVE domain) member 1
PLK3 polo-like kinase 3
PLTP phospholipid transfer protein
POU2F2 POU class 2 homeobox 2
PPFIA3 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 3
PPP5C protein phosphatase 5, catalytic subunit
PRF1 perforin 1 (pore forming protein)
PRPH2 peripherin 2 (retinal degeneration, slow)
PRR4 proline rich 4 (lacrimal)
PTBP3 polypyrimidine tract binding protein 3
PTPN1 protein tyrosine phosphatase, non-receptor type 1
RFXAP regulatory factor X-associated protein
RRBP1 ribosome binding protein 1
RUFY3 RUN and FYVE domain containing 3
S100A8 S100 calcium binding protein A8
SCAND2P SCAN domain containing 2 pseudogene
SH2B1 SH2B adaptor protein 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLC9A8 solute carrier family 9, subfamily A (NHE8, cation proton antiporter 8), member 8
SNRNP200 small nuclear ribonucleoprotein 200kDa (U5)
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
STK24 serine/threonine kinase 24
SYNJ2 synaptojanin 2
SZT2 seizure threshold 2 homolog (mouse)
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
TAP2 transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)
TAS2R1 taste receptor, type 2, member 1
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TFF2 trefoil factor 2
TJAP1 tight junction associated protein 1 (peripheral)
TPMT thiopurine S-methyltransferase
TRBC1 T cell receptor beta constant 1
VEGFA vascular endothelial growth factor A
VPS13D vacuolar protein sorting 13 homolog D (S. cerevisiae)
WSB1 WD repeat and SOCS box containing 1
YIF1B Yip1 interacting factor homolog B (S. cerevisiae)
ZFP36L2 ZFP36 ring finger protein-like 2
ZFYVE9 zinc finger, FYVE domain containing 9
ZNF3 zinc finger protein 3
ZSWIM1 zinc finger, SWIM-type containing 1

decreased expression

Symbol Name
ACTL8 actin-like 8
ADCY6 adenylate cyclase 6
ADCY7 adenylate cyclase 7
AEN apoptosis enhancing nuclease
ARHGDIG Rho GDP dissociation inhibitor (GDI) gamma
ARHGEF10L Rho guanine nucleotide exchange factor (GEF) 10-like
ARID3B AT rich interactive domain 3B (BRIGHT-like)
B9D2 B9 protein domain 2
C16ORF59 chromosome 16 open reading frame 59
C1QTNF9B-AS1 C1QTNF9B antisense RNA 1
C2ORF44 chromosome 2 open reading frame 44
C2ORF54 chromosome 2 open reading frame 54
C7ORF43 chromosome 7 open reading frame 43
CA5BP1 carbonic anhydrase VB pseudogene 1
CBX7 chromobox homolog 7
CCDC68 coiled-coil domain containing 68
CCDC92 coiled-coil domain containing 92
CCNT1 cyclin T1
CEACAM4 carcinoembryonic antigen-related cell adhesion molecule 4
CHM choroideremia (Rab escort protein 1)
CHRM3 cholinergic receptor, muscarinic 3
CLCN5 chloride channel, voltage-sensitive 5
CTSV cathepsin V
DPH2 DPH2 homolog (S. cerevisiae)
EEF2KMT eukaryotic elongation factor 2 lysine methyltransferase
ELOVL4 ELOVL fatty acid elongase 4
EPPK1 epiplakin 1
ERN2 endoplasmic reticulum to nucleus signaling 2
ESRP2 epithelial splicing regulatory protein 2
FAM131A family with sequence similarity 131, member A
FAM189A2 family with sequence similarity 189, member A2
FAM212B family with sequence similarity 212, member B
FKBP10 FK506 binding protein 10, 65 kDa
FOXN2 forkhead box N2
FSD1 fibronectin type III and SPRY domain containing 1
FZD4 frizzled class receptor 4
GABRB2 gamma-aminobutyric acid (GABA) A receptor, beta 2
GAMT guanidinoacetate N-methyltransferase
GAN gigaxonin
GNG7 guanine nucleotide binding protein (G protein), gamma 7
GPX2 glutathione peroxidase 2
HIST1H2BJ histone cluster 1, H2bj
HLCS holocarboxylase synthetase (biotin-(proprionyl-CoA-carboxylase (ATP-hydrolysing)) ligase)
HSPA1L heat shock 70kDa protein 1-like
HYI hydroxypyruvate isomerase (putative)
IDI2-AS1 IDI2 antisense RNA 1
IFIT5 interferon-induced protein with tetratricopeptide repeats 5
IKZF5 IKAROS family zinc finger 5 (Pegasus)
KANSL1L KAT8 regulatory NSL complex subunit 1-like
KCNK12 potassium channel, two pore domain subfamily K, member 12
KLC2 kinesin light chain 2
KLHL25 kelch-like family member 25
KLHL26 kelch-like family member 26
LAMA3 laminin, alpha 3
LYPD3 LY6/PLAUR domain containing 3
MPP3 membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3)
MTCL1 microtubule crosslinking factor 1
MYO1F myosin IF
NOL12 nucleolar protein 12
NPFFR1 neuropeptide FF receptor 1
NRGN neurogranin (protein kinase C substrate, RC3)
OLFML3 olfactomedin-like 3
ORC1 origin recognition complex, subunit 1
PDPR pyruvate dehydrogenase phosphatase regulatory subunit
PGP phosphoglycolate phosphatase
PHKG2 phosphorylase kinase, gamma 2 (testis)
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)
PLEKHA2 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 2
POMT2 protein-O-mannosyltransferase 2
PRRG4 proline rich Gla (G-carboxyglutamic acid) 4 (transmembrane)
QTRT1 queuine tRNA-ribosyltransferase 1
RAD9A RAD9 homolog A (S. pombe)
RASSF1 Ras association (RalGDS/AF-6) domain family member 1
RBM38 RNA binding motif protein 38
RNF126P1 ring finger protein 126 pseudogene 1
RNF2 ring finger protein 2
SEMA4A sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A
SHPK sedoheptulokinase
SKIV2L superkiller viralicidic activity 2-like (S. cerevisiae)
SLC22A4 solute carrier family 22 (organic cation/zwitterion transporter), member 4
SLC25A23 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 23
SLC35C1 solute carrier family 35 (GDP-fucose transporter), member C1
SOX3 SRY (sex determining region Y)-box 3
STX1A syntaxin 1A (brain)
TCP10 t-complex 10
TICAM1 toll-like receptor adaptor molecule 1
TMC5 transmembrane channel-like 5
TMEM180 transmembrane protein 180
TMPRSS3 transmembrane protease, serine 3
TTLL1 tubulin tyrosine ligase-like family member 1
TXNIP thioredoxin interacting protein
WDR76 WD repeat domain 76
ZAK sterile alpha motif and leucine zipper containing kinase AZK
ZBTB48 zinc finger and BTB domain containing 48
ZDHHC11 zinc finger, DHHC-type containing 11
ZNF137P zinc finger protein 137, pseudogene
ZNF639 zinc finger protein 639