bethanechol-5114 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

195 genes differentially expressed following the bethanechol-5114 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ALPPL2 alkaline phosphatase, placental-like 2
ARHGAP26 Rho GTPase activating protein 26
ASAP3 ArfGAP with SH3 domain, ankyrin repeat and PH domain 3
ASTN2 astrotactin 2
AURKC aurora kinase C
BRINP2 bone morphogenetic protein/retinoic acid inducible neural-specific 2
C5ORF42 chromosome 5 open reading frame 42
CADM1 cell adhesion molecule 1
CAMKMT calmodulin-lysine N-methyltransferase
CCDC88C coiled-coil domain containing 88C
CCNA1 cyclin A1
CD300C CD300c molecule
CDT1 chromatin licensing and DNA replication factor 1
CENPT centromere protein T
CHRDL1 chordin-like 1
COQ7 coenzyme Q7 homolog, ubiquinone (yeast)
CRY2 cryptochrome circadian clock 2
CRYGC crystallin, gamma C
CYHR1 cysteine/histidine-rich 1
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
DZIP1 DAZ interacting zinc finger protein 1
ECE1 endothelin converting enzyme 1
EDNRA endothelin receptor type A
ELK4 ELK4, ETS-domain protein (SRF accessory protein 1)
ETV4 ets variant 4
FAM131B family with sequence similarity 131, member B
FAM134B family with sequence similarity 134, member B
FAM53B family with sequence similarity 53, member B
FAM63B family with sequence similarity 63, member B
FKRP fukutin related protein
FRMPD1 FERM and PDZ domain containing 1
GLB1L galactosidase, beta 1-like
GRTP1 growth hormone regulated TBC protein 1
HDAC7 histone deacetylase 7
HIC2 hypermethylated in cancer 2
HOOK1 hook microtubule-tethering protein 1
ICA1 islet cell autoantigen 1, 69kDa
INF2 inverted formin, FH2 and WH2 domain containing
INPP4A inositol polyphosphate-4-phosphatase, type I, 107kDa
ITGB5 integrin, beta 5
KCTD13 potassium channel tetramerization domain containing 13
KHSRP KH-type splicing regulatory protein
KLHL25 kelch-like family member 25
LAT2 linker for activation of T cells family, member 2
LATS1 large tumor suppressor kinase 1
LRP4 low density lipoprotein receptor-related protein 4
MAP2K6 mitogen-activated protein kinase kinase 6
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2
MLLT4 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4
MXD4 MAX dimerization protein 4
MYH14 myosin, heavy chain 14, non-muscle
NAB2 NGFI-A binding protein 2 (EGR1 binding protein 2)
NFX1 nuclear transcription factor, X-box binding 1
NRN1 neuritin 1
OGFR opioid growth factor receptor
ONECUT2 one cut homeobox 2
OPA3 optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia)
PCDHB3 protocadherin beta 3
PDLIM5 PDZ and LIM domain 5
PECAM1 platelet/endothelial cell adhesion molecule 1
PPIL2 peptidylprolyl isomerase (cyclophilin)-like 2
PPP3R1 protein phosphatase 3, regulatory subunit B, alpha
PRKACA protein kinase, cAMP-dependent, catalytic, alpha
RBMS2 RNA binding motif, single stranded interacting protein 2
RCN3 reticulocalbin 3, EF-hand calcium binding domain
RGS10 regulator of G-protein signaling 10
RIN3 Ras and Rab interactor 3
RPL10 ribosomal protein L10
RPS3A ribosomal protein S3A
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
RUNX1 runt-related transcription factor 1
SAA3P serum amyloid A3 pseudogene
SARM1 sterile alpha and TIR motif containing 1
SCN4A sodium channel, voltage gated, type IV alpha subunit
SECISBP2 SECIS binding protein 2
SFTPB surfactant protein B
SLC12A4 solute carrier family 12 (potassium/chloride transporter), member 4
SLC35D1 solute carrier family 35 (UDP-GlcA/UDP-GalNAc transporter), member D1
SLC4A3 solute carrier family 4 (anion exchanger), member 3
SMG7 SMG7 nonsense mediated mRNA decay factor
ST20 suppressor of tumorigenicity 20
TBC1D30 TBC1 domain family, member 30
TBX5 T-box 5
TCF3 transcription factor 3
TCL6 T-cell leukemia/lymphoma 6 (non-protein coding)
TMC6 transmembrane channel-like 6
TMEFF1 transmembrane protein with EGF-like and two follistatin-like domains 1
TRMT1 tRNA methyltransferase 1 homolog (S. cerevisiae)
TSPAN12 tetraspanin 12
TTC30A tetratricopeptide repeat domain 30A
TUBB2B tubulin, beta 2B class IIb
UPK1B uroplakin 1B
URB1 URB1 ribosome biogenesis 1 homolog (S. cerevisiae)
UST uronyl-2-sulfotransferase
ZCCHC11 zinc finger, CCHC domain containing 11
ZMIZ2 zinc finger, MIZ-type containing 2
ZNF37BP zinc finger protein 37B, pseudogene
ZNF492 zinc finger protein 492
ZNF710 zinc finger protein 710
ZNF821 zinc finger protein 821

decreased expression

Symbol Name
ADGRB2 adhesion G protein-coupled receptor B2
AGPAT3 1-acylglycerol-3-phosphate O-acyltransferase 3
AMT aminomethyltransferase
ATAT1 alpha tubulin acetyltransferase 1
B4GALNT1 beta-1,4-N-acetyl-galactosaminyl transferase 1
BATF3 basic leucine zipper transcription factor, ATF-like 3
BCAS3 breast carcinoma amplified sequence 3
C1ORF105 chromosome 1 open reading frame 105
C4ORF29 chromosome 4 open reading frame 29
CA11 carbonic anhydrase XI
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase
CDK6 cyclin-dependent kinase 6
CENPO centromere protein O
CFAP45 cilia and flagella associated protein 45
COX6A2 cytochrome c oxidase subunit VIa polypeptide 2
CPA4 carboxypeptidase A4
CPPED1 calcineurin-like phosphoesterase domain containing 1
CSF1R colony stimulating factor 1 receptor
CYP7B1 cytochrome P450, family 7, subfamily B, polypeptide 1
DAPP1 dual adaptor of phosphotyrosine and 3-phosphoinositides
DEPTOR DEP domain containing MTOR-interacting protein
EPHA4 EPH receptor A4
EYA3 EYA transcriptional coactivator and phosphatase 3
FAM184A family with sequence similarity 184, member A
FBRS fibrosin
FKBP5 FK506 binding protein 5
FUZ fuzzy planar cell polarity protein
GALK1 galactokinase 1
GIF gastric intrinsic factor (vitamin B synthesis)
GPRIN2 G protein regulated inducer of neurite outgrowth 2
HIST1H1E histone cluster 1, H1e
HIST1H2BJ histone cluster 1, H2bj
HOXA1 homeobox A1
HOXC5 homeobox C5
ICOS inducible T-cell co-stimulator
IDI2-AS1 IDI2 antisense RNA 1
IFNA2 interferon, alpha 2
IFNAR1 interferon (alpha, beta and omega) receptor 1
IKZF5 IKAROS family zinc finger 5 (Pegasus)
IL22 interleukin 22
IRAK4 interleukin-1 receptor-associated kinase 4
KCNN1 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 1
KIAA1107 KIAA1107
KRT86 keratin 86, type II
LOC390998 ribosomal protein L10 pseudogene
LOXL3 lysyl oxidase-like 3
LRRK1 leucine-rich repeat kinase 1
LY6G5C lymphocyte antigen 6 complex, locus G5C
MBTPS2 membrane-bound transcription factor peptidase, site 2
MCC mutated in colorectal cancers
MFGE8 milk fat globule-EGF factor 8 protein
MGC12488
P2RY1 purinergic receptor P2Y, G-protein coupled, 1
PARD6A par-6 family cell polarity regulator alpha
PDE6C phosphodiesterase 6C, cGMP-specific, cone, alpha prime
PRKG2 protein kinase, cGMP-dependent, type II
PRKRIP1 PRKR interacting protein 1 (IL11 inducible)
PRSS22 protease, serine, 22
PTCD2 pentatricopeptide repeat domain 2
RAB3A RAB3A, member RAS oncogene family
RAB4B RAB4B, member RAS oncogene family
RAC3 ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3)
RBMS3 RNA binding motif, single stranded interacting protein 3
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RPL13P5 ribosomal protein L13 pseudogene 5
SCN1B sodium channel, voltage gated, type I beta subunit
SCUBE3 signal peptide, CUB domain, EGF-like 3
SETD6 SET domain containing 6
SH3GLB2 SH3-domain GRB2-like endophilin B2
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1
SLC44A1 solute carrier family 44 (choline transporter), member 1
SNPH syntaphilin
SPRYD7 SPRY domain containing 7
STAG3 stromal antigen 3
SUGCT succinyl-CoA:glutarate-CoA transferase
SULT2B1 sulfotransferase family, cytosolic, 2B, member 1
TAGLN3 transgelin 3
TAOK1 TAO kinase 1
THRB thyroid hormone receptor, beta
TMEM132A transmembrane protein 132A
TMEM212 transmembrane protein 212
TRIM25 tripartite motif containing 25
TRIM45 tripartite motif containing 45
TSC22D4 TSC22 domain family, member 4
TSPAN1 tetraspanin 1
UBQLN4 ubiquilin 4
VGF VGF nerve growth factor inducible
WDR33 WD repeat domain 33
ZBTB33 zinc finger and BTB domain containing 33
ZNF222 zinc finger protein 222
ZNF225 zinc finger protein 225
ZNF254 zinc finger protein 254
ZNF446 zinc finger protein 446
ZNF76 zinc finger protein 76
ZNHIT2 zinc finger, HIT-type containing 2