bethanechol-5539 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

196 genes differentially expressed following the bethanechol-5539 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCA7 ATP-binding cassette, sub-family A (ABC1), member 7
ACAN aggrecan
ACTG2 actin, gamma 2, smooth muscle, enteric
ADAM22 ADAM metallopeptidase domain 22
AHI1 Abelson helper integration site 1
AKAP8L A kinase (PRKA) anchor protein 8-like
AP3D1 adaptor-related protein complex 3, delta 1 subunit
AP5Z1 adaptor-related protein complex 5, zeta 1 subunit
APBA1 amyloid beta (A4) precursor protein-binding, family A, member 1
ASPH aspartate beta-hydroxylase
ASPN asporin
BEX1 brain expressed, X-linked 1
BTF3P11 basic transcription factor 3 pseudogene 11
C1ORF54 chromosome 1 open reading frame 54
CD79B CD79b molecule, immunoglobulin-associated beta
CDC25C cell division cycle 25C
CDHR2 cadherin-related family member 2
CHRNE cholinergic receptor, nicotinic, epsilon (muscle)
CLTB clathrin, light chain B
CNKSR2 connector enhancer of kinase suppressor of Ras 2
COPS7B COP9 signalosome subunit 7B
CROCC ciliary rootlet coiled-coil, rootletin
CYP2C19 cytochrome P450, family 2, subfamily C, polypeptide 19
CYP3A43 cytochrome P450, family 3, subfamily A, polypeptide 43
CYP4F3 cytochrome P450, family 4, subfamily F, polypeptide 3
CYP7B1 cytochrome P450, family 7, subfamily B, polypeptide 1
DDX3X DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked
DIO2 deiodinase, iodothyronine, type II
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha
DNPH1 2'-deoxynucleoside 5'-phosphate N-hydrolase 1
DRD2 dopamine receptor D2
DST dystonin
DYNC1LI2 dynein, cytoplasmic 1, light intermediate chain 2
EPHB6 EPH receptor B6
FAM149B1 family with sequence similarity 149, member B1
FBN1 fibrillin 1
FBXO40 F-box protein 40
FOXG1 forkhead box G1
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila)
GAD2 glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)
GK glycerol kinase
GYG2 glycogenin 2
HLA-DOB major histocompatibility complex, class II, DO beta
HPCAL4 hippocalcin like 4
IFI6 interferon, alpha-inducible protein 6
IFITM1 interferon induced transmembrane protein 1
IGFBP3 insulin-like growth factor binding protein 3
IGLL1 immunoglobulin lambda-like polypeptide 1
IRF2BP1 interferon regulatory factor 2 binding protein 1
IRS2 insulin receptor substrate 2
KIR3DS1 killer cell immunoglobulin-like receptor, three domains, short cytoplasmic tail, 1
KRIT1 KRIT1, ankyrin repeat containing
LECT1 leukocyte cell derived chemotaxin 1
LPCAT3 lysophosphatidylcholine acyltransferase 3
LPIN1 lipin 1
LZTS3 leucine zipper, putative tumor suppressor family member 3
MTA1 metastasis associated 1
MYLK myosin light chain kinase
NCALD neurocalcin delta
NDUFAF5 NADH dehydrogenase (ubiquinone) complex I, assembly factor 5
NOVA2 neuro-oncological ventral antigen 2
PCCA propionyl CoA carboxylase, alpha polypeptide
PLA2G4C phospholipase A2, group IVC (cytosolic, calcium-independent)
PLAC4 placenta-specific 4
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
POU5F1B POU class 5 homeobox 1B
PPP1R17 protein phosphatase 1, regulatory subunit 17
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5
RRBP1 ribosome binding protein 1
SCN10A sodium channel, voltage gated, type X alpha subunit
SDHD succinate dehydrogenase complex, subunit D, integral membrane protein
SMAD4 SMAD family member 4
SOX15 SRY (sex determining region Y)-box 15
SPINK5 serine peptidase inhibitor, Kazal type 5
SPTLC3 serine palmitoyltransferase, long chain base subunit 3
SSTR5 somatostatin receptor 5
SSX3 synovial sarcoma, X breakpoint 3
SUGP1 SURP and G patch domain containing 1
SYT11 synaptotagmin XI
TBX5 T-box 5
TCEB3B transcription elongation factor B polypeptide 3B (elongin A2)
TCP11L1 t-complex 11, testis-specific-like 1
TMEM63A transmembrane protein 63A
TOM1 target of myb1 (chicken)
TOP3A topoisomerase (DNA) III alpha
TREX1 three prime repair exonuclease 1
TTLL3 tubulin tyrosine ligase-like family member 3
VAC14 Vac14 homolog (S. cerevisiae)
VARS valyl-tRNA synthetase
VIPR1 vasoactive intestinal peptide receptor 1
WHSC1 Wolf-Hirschhorn syndrome candidate 1
ZIM2 zinc finger, imprinted 2
ZNF471 zinc finger protein 471
ZNF500 zinc finger protein 500
ZNF639 zinc finger protein 639
ZNF778 zinc finger protein 778
ZNF862 zinc finger protein 862

decreased expression

Symbol Name
AFF4 AF4/FMR2 family, member 4
ALPK1 alpha-kinase 1
ANAPC2 anaphase promoting complex subunit 2
ANXA1 annexin A1
ATG4A autophagy related 4A, cysteine peptidase
ATP7B ATPase, Cu++ transporting, beta polypeptide
BCKDHA branched chain keto acid dehydrogenase E1, alpha polypeptide
BIRC7 baculoviral IAP repeat containing 7
C4ORF29 chromosome 4 open reading frame 29
C9ORF9 chromosome 9 open reading frame 9
CAMTA2 calmodulin binding transcription activator 2
CASP3 caspase 3, apoptosis-related cysteine peptidase
CCDC186 coiled-coil domain containing 186
CD83 CD83 molecule
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CEP72 centrosomal protein 72kDa
CES3 carboxylesterase 3
CFAP44 cilia and flagella associated protein 44
CIC capicua transcriptional repressor
CLN6 ceroid-lipofuscinosis, neuronal 6, late infantile, variant
CNNM4 cyclin and CBS domain divalent metal cation transport mediator 4
EFNA3 ephrin-A3
EPB41L5 erythrocyte membrane protein band 4.1 like 5
ERN2 endoplasmic reticulum to nucleus signaling 2
FANCC Fanconi anemia, complementation group C
FGD6 FYVE, RhoGEF and PH domain containing 6
FGGY FGGY carbohydrate kinase domain containing
FKBPL FK506 binding protein like
GAB2 GRB2-associated binding protein 2
GABPA GA binding protein transcription factor, alpha subunit 60kDa
GABRB2 gamma-aminobutyric acid (GABA) A receptor, beta 2
GINS4 GINS complex subunit 4 (Sld5 homolog)
GLI3 GLI family zinc finger 3
HCFC2 host cell factor C2
HGSNAT heparan-alpha-glucosaminide N-acetyltransferase
HHLA3 HERV-H LTR-associating 3
HIRA histone cell cycle regulator
HIST1H1B histone cluster 1, H1b
HIST1H1D histone cluster 1, H1d
HIST1H2AJ histone cluster 1, H2aj
HIST1H2AL histone cluster 1, H2al
HS3ST3A1 heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1
HSPA2 heat shock 70kDa protein 2
IFT22 intraflagellar transport 22
ITPKC inositol-trisphosphate 3-kinase C
KAT2A K(lysine) acetyltransferase 2A
KCTD7 potassium channel tetramerization domain containing 7
KIAA0894 KIAA0894 protein
KREMEN2 kringle containing transmembrane protein 2
LAX1 lymphocyte transmembrane adaptor 1
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LMNB2 lamin B2
LOC202181 SUMO-interacting motifs containing 1 pseudogene
LY6D lymphocyte antigen 6 complex, locus D
LZTFL1 leucine zipper transcription factor-like 1
MCOLN3 mucolipin 3
MUL1 mitochondrial E3 ubiquitin protein ligase 1
MYL5 myosin, light chain 5, regulatory
NPFFR1 neuropeptide FF receptor 1
NSMF NMDA receptor synaptonuclear signaling and neuronal migration factor
ONECUT2 one cut homeobox 2
PCSK1N proprotein convertase subtilisin/kexin type 1 inhibitor
PGPEP1 pyroglutamyl-peptidase I
PMEPA1 prostate transmembrane protein, androgen induced 1
PRRG2 proline rich Gla (G-carboxyglutamic acid) 2
PRRG4 proline rich Gla (G-carboxyglutamic acid) 4 (transmembrane)
PSKH1 protein serine kinase H1
R3HCC1L R3H domain and coiled-coil containing 1-like
RAB3A RAB3A, member RAS oncogene family
RAC3 ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3)
RFTN1 raftlin, lipid raft linker 1
RHPN1-AS1 RHPN1 antisense RNA 1 (head to head)
RNF122 ring finger protein 122
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase
SEMA4D sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D
SETD8 SET domain containing (lysine methyltransferase) 8
SKI SKI proto-oncogene
SLC46A3 solute carrier family 46, member 3
SMIM14 small integral membrane protein 14
SREK1IP1 SREK1-interacting protein 1
ST3GAL1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
SUZ12P1 suppressor of zeste 12 homolog pseudogene 1
TGFBR3 transforming growth factor, beta receptor III
THNSL1 threonine synthase-like 1 (S. cerevisiae)
TRAF2 TNF receptor-associated factor 2
TRPC4AP transient receptor potential cation channel, subfamily C, member 4 associated protein
TRPV1 transient receptor potential cation channel, subfamily V, member 1
UNKL unkempt family zinc finger-like
WDR19 WD repeat domain 19
WLS wntless Wnt ligand secretion mediator
XAB2 XPA binding protein 2
XYLT2 xylosyltransferase II
ZNF141 zinc finger protein 141
ZNF273 zinc finger protein 273
ZNF282 zinc finger protein 282
ZNF329 zinc finger protein 329
ZNF365 zinc finger protein 365
ZNF652 zinc finger protein 652