bicellular tight junction Gene Set

Dataset GO Cellular Component Annotations 2023
Category structural or functional annotations
Type biological process
Description An occluding cell-cell junction that is composed of a branching network of sealing strands that completely encircles the apical end of each cell in an epithelial sheet; the outer leaflets of the two interacting plasma membranes are seen to be tightly apposed where sealing strands are present. Each sealing strand is composed of a long row of transmembrane adhesion proteins embedded in each of the two interacting plasma membranes. (Gene Ontology, GO_0005923)
External Link http://amigo.geneontology.org/amigo/term/GO:0005923
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Genes

82 proteins localized to the bicellular tight junction cellular component from the curated GO Cellular Component Annotations 2023 dataset.

Symbol Name
AMICA1 adhesion molecule, interacts with CXADR antigen 1
AMOT angiomotin
AMOTL1 angiomotin like 1
AMOTL2 angiomotin like 2
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
AOC1 amine oxidase, copper containing 1
APC adenomatous polyposis coli
BVES blood vessel epicardial substance
CDH5 cadherin 5, type 2 (vascular endothelium)
CGN cingulin
CGNL1 cingulin-like 1
CHAF1B chromatin assembly factor 1, subunit B (p60)
CLDN1 claudin 1
CLDN10 claudin 10
CLDN11 claudin 11
CLDN12 claudin 12
CLDN14 claudin 14
CLDN15 claudin 15
CLDN16 claudin 16
CLDN17 claudin 17
CLDN18 claudin 18
CLDN19 claudin 19
CLDN2 claudin 2
CLDN20 claudin 20
CLDN22 claudin 22
CLDN23 claudin 23
CLDN24 claudin 24
CLDN25 claudin 25
CLDN3 claudin 3
CLDN4 claudin 4
CLDN5 claudin 5
CLDN6 claudin 6
CLDN7 claudin 7
CLDN8 claudin 8
CLDN9 claudin 9
CLMP CXADR-like membrane protein
CXADR coxsackie virus and adenovirus receptor
CYTH1 cytohesin 1
CYTH3 cytohesin 3
DDX58 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
DLG1 discs, large homolog 1 (Drosophila)
ECT2 epithelial cell transforming 2
EPCAM epithelial cell adhesion molecule
EPPK1 epiplakin 1
F11R F11 receptor
FRMD4A FERM domain containing 4A
FRMD4B FERM domain containing 4B
FRMPD2 FERM and PDZ domain containing 2
IGSF5 immunoglobulin superfamily, member 5
JAM3 junctional adhesion molecule 3
LOC100288814
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2
MARVELD2 MARVEL domain containing 2
MARVELD3 MARVEL domain containing 3
MICALL2 MICAL-like 2
MPDZ multiple PDZ domain protein
MTDH metadherin
OCEL1 occludin/ELL domain containing 1
OCLN occludin
PARD3 par-3 family cell polarity regulator
PARD6A par-6 family cell polarity regulator alpha
PARD6B par-6 family cell polarity regulator beta
PATJ PATJ crumbs cell polarity complex component
POF1B premature ovarian failure, 1B
RAB13 RAB13, member RAS oncogene family
RAP2B RAP2B, member of RAS oncogene family
RAP2C RAP2C, member of RAS oncogene family
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2
SH3BP1 SH3-domain binding protein 1
SHROOM2 shroom family member 2
STRN striatin, calmodulin binding protein
TBCD tubulin folding cofactor D
TGFBR1 transforming growth factor, beta receptor 1
TJP1 tight junction protein 1
TJP2 tight junction protein 2
TJP3 tight junction protein 3
UBN1 ubinuclein 1
USP53 ubiquitin specific peptidase 53
VAPA VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa
WNK3 WNK lysine deficient protein kinase 3
WNK4 WNK lysine deficient protein kinase 4
YBX3 Y box binding protein 3