bid Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description BH3 interacting domain death agonist|This gene encodes a death agonist that heterodimerizes with either agonist BAX or antagonist BCL2. The encoded protein is a member of the BCL-2 family of cell death regulators. It is a mediator of mitochondrial damage induced by caspase-8 (CASP8); CASP8 cleaves this encoded protein, and the COOH-terminal part translocates to mitochondria where it triggers cytochrome c release. Multiple alternatively spliced transcript variants have been found, but the full-length nature of some variants has not been defined. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 637)
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Genes

63 genes co-occuring with the biological term bid in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ADORA2A adenosine A2a receptor
AKT1 v-akt murine thymoma viral oncogene homolog 1
APAF1 apoptotic peptidase activating factor 1
ATR ATR serine/threonine kinase
BAD BCL2-associated agonist of cell death
BAK1 BCL2-antagonist/killer 1
BAX BCL2-associated X protein
BBC3 BCL2 binding component 3
BCL2 B-cell CLL/lymphoma 2
BCL2A1 BCL2-related protein A1
BCL2L1 BCL2-like 1
BCL2L11 BCL2-like 11 (apoptosis facilitator)
BCL2L2 BCL2-like 2
BID BH3 interacting domain death agonist
BIRC5 baculoviral IAP repeat containing 5
BMF Bcl2 modifying factor
BRAF B-Raf proto-oncogene, serine/threonine kinase
CASP10 caspase 10, apoptosis-related cysteine peptidase
CASP2 caspase 2, apoptosis-related cysteine peptidase
CASP3 caspase 3, apoptosis-related cysteine peptidase
CASP8 caspase 8, apoptosis-related cysteine peptidase
CASP9 caspase 9, apoptosis-related cysteine peptidase
CCL2 chemokine (C-C motif) ligand 2
CD40 CD40 molecule, TNF receptor superfamily member 5
CFLAR CASP8 and FADD-like apoptosis regulator
COX6C cytochrome c oxidase subunit VIc
COX7B cytochrome c oxidase subunit VIIb
CSNK2A1 casein kinase 2, alpha 1 polypeptide
CTSB cathepsin B
CTSD cathepsin D
CYCS cytochrome c, somatic
ENDOG endonuclease G
ERCC4 excision repair cross-complementation group 4
F2 coagulation factor II (thrombin)
FADD Fas (TNFRSF6)-associated via death domain
FAS Fas cell surface death receptor
FOXL2 forkhead box L2
GLI1 GLI family zinc finger 1
GNLY granulysin
GZMA granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)
GZMB granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HRK harakiri, BCL2 interacting protein
KAT2B K(lysine) acetyltransferase 2B
MAPK8 mitogen-activated protein kinase 8
MCL1 myeloid cell leukemia 1
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MICAL3 microtubule associated monooxygenase, calponin and LIM domain containing 3
MTCH2 mitochondrial carrier 2
PARP1 poly (ADP-ribose) polymerase 1
PGR progesterone receptor
PRKCE protein kinase C, epsilon
RPA1 replication protein A1, 70kDa
RTN3 reticulon 3
ST13 suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein)
TADA3 transcriptional adaptor 3
TNF tumor necrosis factor
TNFRSF10A tumor necrosis factor receptor superfamily, member 10a
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TP53 tumor protein p53
XIAP X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta