bile Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description A fluid secreted by the liver and poured into the small intestine via the bile ducts. Important constituents are conjugated bile salts, cholesterol, phospholipid, bilirubin diglucuronide, and electrolytes. Bile is alkaline due to its bicarbonate content, is golden brown to greenish yellow in color, and has a bitter taste. Bile secreted by the liver is concentrated in the gallbladder. (BRENDA Tissue and Enzyme Source Ontology, BTO_0000121)
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Genes

248 genes co-occuring with the biological term bile in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1
ABCB11 ATP-binding cassette, sub-family B (MDR/TAP), member 11
ABCB4 ATP-binding cassette, sub-family B (MDR/TAP), member 4
ABCC11 ATP-binding cassette, sub-family C (CFTR/MRP), member 11
ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
ABCG5 ATP-binding cassette, sub-family G (WHITE), member 5
ABCG8 ATP-binding cassette, sub-family G (WHITE), member 8
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AICDA activation-induced cytidine deaminase
AKR1C2 aldo-keto reductase family 1, member C2
AKR1D1 aldo-keto reductase family 1, member D1
ANGPTL4 angiopoietin-like 4
ANPEP alanyl (membrane) aminopeptidase
APOB apolipoprotein B
APOE apolipoprotein E
AQP8 aquaporin 8
ARV1 ARV1 homolog (S. cerevisiae)
ASPH aspartate beta-hydroxylase
ATP7B ATPase, Cu++ transporting, beta polypeptide
ATP8B1 ATPase, aminophospholipid transporter, class I, type 8B, member 1
AZU1 azurocidin 1
BAAT bile acid CoA:amino acid N-acyltransferase
BECN1 beclin 1, autophagy related
BMI1 BMI1 proto-oncogene, polycomb ring finger
BRAF B-Raf proto-oncogene, serine/threonine kinase
C3 complement component 3
CADM1 cell adhesion molecule 1
CAMP cathelicidin antimicrobial peptide
CAV1 caveolin 1, caveolae protein, 22kDa
CAV2 caveolin 2
CCL2 chemokine (C-C motif) ligand 2
CCL20 chemokine (C-C motif) ligand 20
CCND1 cyclin D1
CCR2 chemokine (C-C motif) receptor 2
CCR6 chemokine (C-C motif) receptor 6
CD209 CD209 molecule
CD24 CD24 molecule
CD38 CD38 molecule
CD40 CD40 molecule, TNF receptor superfamily member 5
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN2A cyclin-dependent kinase inhibitor 2A
CDX2 caudal type homeobox 2
CEL carboxyl ester lipase
CES1 carboxylesterase 1
CFLAR CASP8 and FADD-like apoptosis regulator
CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)
CKB creatine kinase, brain
CLDN1 claudin 1
CLU clusterin
CNR1 cannabinoid receptor 1 (brain)
CREB1 cAMP responsive element binding protein 1
CRYAA crystallin, alpha A
CTTN cortactin
CX3CL1 chemokine (C-X3-C motif) ligand 1
CX3CR1 chemokine (C-X3-C motif) receptor 1
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL8 chemokine (C-X-C motif) ligand 8
CXCR3 chemokine (C-X-C motif) receptor 3
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
CYP7A1 cytochrome P450, family 7, subfamily A, polypeptide 1
CYP8B1 cytochrome P450, family 8, subfamily B, polypeptide 1
DCTN4 dynactin 4 (p62)
DMBT1 deleted in malignant brain tumors 1
EBAG9 estrogen receptor binding site associated, antigen, 9
EGFR epidermal growth factor receptor
EHMT2 euchromatic histone-lysine N-methyltransferase 2
ENPP3 ectonucleotide pyrophosphatase/phosphodiesterase 3
ENTPD2 ectonucleoside triphosphate diphosphohydrolase 2
ESR1 estrogen receptor 1
ESR2 estrogen receptor 2 (ER beta)
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
F2RL1 coagulation factor II (thrombin) receptor-like 1
FABP6 fatty acid binding protein 6, ileal
FAS Fas cell surface death receptor
FASLG Fas ligand (TNF superfamily, member 6)
FASN fatty acid synthase
FGF19 fibroblast growth factor 19
FGF21 fibroblast growth factor 21
FGF7 fibroblast growth factor 7
FGFR4 fibroblast growth factor receptor 4
FOXA2 forkhead box A2
FSCN1 fascin actin-bundling protein 1
GALNT3 polypeptide N-acetylgalactosaminyltransferase 3
GBA2 glucosidase, beta (bile acid) 2
GGT1 gamma-glutamyltransferase 1
GNAS GNAS complex locus
GOLM1 golgi membrane protein 1
GPBAR1 G protein-coupled bile acid receptor 1
GPS2 G protein pathway suppressor 2
GSTP1 glutathione S-transferase pi 1
GUCA2A guanylate cyclase activator 2A (guanylin)
GUCY2C guanylate cyclase 2C
HAMP hepcidin antimicrobial peptide
HAX1 HCLS1 associated protein X-1
HDC histidine decarboxylase
HES1 hes family bHLH transcription factor 1
HGF hepatocyte growth factor (hepapoietin A; scatter factor)
HHEX hematopoietically expressed homeobox
HMGA1 high mobility group AT-hook 1
HMGA2 high mobility group AT-hook 2
HMOX1 heme oxygenase 1
HNF4A hepatocyte nuclear factor 4, alpha
HOXB7 homeobox B7
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSD11B1 hydroxysteroid (11-beta) dehydrogenase 1
HSD3B7 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7
ICAM1 intercellular adhesion molecule 1
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IL10 interleukin 10
IL1RN interleukin 1 receptor antagonist
IL2RA interleukin 2 receptor, alpha
IL6 interleukin 6
ITGAL integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)
ITGAV integrin, alpha V
ITGB6 integrin, beta 6
JUN jun proto-oncogene
KCNN2 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 2
KLB klotho beta
KRAS Kirsten rat sarcoma viral oncogene homolog
LCN2 lipocalin 2
LDLR low density lipoprotein receptor
LEP leptin
LIPA lipase A, lysosomal acid, cholesterol esterase
LPA lipoprotein, Lp(a)
MAPK1 mitogen-activated protein kinase 1
MAPK3 mitogen-activated protein kinase 3
MAX MYC associated factor X
MIR200C microRNA 200c
MIR9-1 microRNA 9-1
MIR9-2 microRNA 9-2
MIR9-3 microRNA 9-3
MME membrane metallo-endopeptidase
MMP2 matrix metallopeptidase 2
MMP7 matrix metallopeptidase 7
MMP9 matrix metallopeptidase 9
MNT MAX network transcriptional repressor
MSLN mesothelin
MTOR mechanistic target of rapamycin (serine/threonine kinase)
MTTP microsomal triglyceride transfer protein
MUC1 mucin 1, cell surface associated
MUC2 mucin 2, oligomeric mucus/gel-forming
MUC4 mucin 4, cell surface associated
MUC6 mucin 6, oligomeric mucus/gel-forming
MX1 MX dynamin-like GTPase 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYO5B myosin VB
NFE2L2 nuclear factor, erythroid 2-like 2
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NOTCH2 notch 2
NOX5 NADPH oxidase, EF-hand calcium binding domain 5
NPC1L1 NPC1-like 1
NPC2 Niemann-Pick disease, type C2
NR0B2 nuclear receptor subfamily 0, group B, member 2
NR1H3 nuclear receptor subfamily 1, group H, member 3
NR1H4 nuclear receptor subfamily 1, group H, member 4
NR1I2 nuclear receptor subfamily 1, group I, member 2
NR5A2 nuclear receptor subfamily 5, group A, member 2
NUP210 nucleoporin 210kDa
OFD1 oral-facial-digital syndrome 1
ORM1 orosomucoid 1
PCSK9 proprotein convertase subtilisin/kexin type 9
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
PKM pyruvate kinase, muscle
PLA2G1B phospholipase A2, group IB (pancreas)
PLCG2 phospholipase C, gamma 2 (phosphatidylinositol-specific)
PLTP phospholipid transfer protein
PNLIP pancreatic lipase
PNLIPRP2 pancreatic lipase-related protein 2
PNPLA3 patatin-like phospholipase domain containing 3
PODXL podocalyxin-like
PON1 paraoxonase 1
POSTN periostin, osteoblast specific factor
PPARA peroxisome proliferator-activated receptor alpha
PPARG peroxisome proliferator-activated receptor gamma
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
PPRC1 peroxisome proliferator-activated receptor gamma, coactivator-related 1
PRKAR2A protein kinase, cAMP-dependent, regulatory, type II, alpha
PRKCA protein kinase C, alpha
PRKCZ protein kinase C, zeta
PROX1 prospero homeobox 1
PRTN3 proteinase 3
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
REG1A regenerating islet-derived 1 alpha
RGN regucalcin
RNU2-1 RNA, U2 small nuclear 1
ROCK1 Rho-associated, coiled-coil containing protein kinase 1
RORA RAR-related orphan receptor A
RPS6KA5 ribosomal protein S6 kinase, 90kDa, polypeptide 5
RPSA ribosomal protein SA
S100A8 S100 calcium binding protein A8
S100P S100 calcium binding protein P
S1PR2 sphingosine-1-phosphate receptor 2
SBNO1 strawberry notch homolog 1 (Drosophila)
SCARB1 scavenger receptor class B, member 1
SCT secretin
SCTR secretin receptor
SDC1 syndecan 1
SFTPA1 surfactant protein A1
SFTPD surfactant protein D
SLC10A1 solute carrier family 10 (sodium/bile acid cotransporter), member 1
SLC10A2 solute carrier family 10 (sodium/bile acid cotransporter), member 2
SLC27A5 solute carrier family 27 (fatty acid transporter), member 5
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SLC2A2 solute carrier family 2 (facilitated glucose transporter), member 2
SLC47A1 solute carrier family 47 (multidrug and toxin extrusion), member 1
SLC51A solute carrier family 51, alpha subunit
SLC51B solute carrier family 51, beta subunit
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1
SLC9A6 solute carrier family 9, subfamily A (NHE6, cation proton antiporter 6), member 6
SLCO1B1 solute carrier organic anion transporter family, member 1B1
SLCO1B3 solute carrier organic anion transporter family, member 1B3
SMAD4 SMAD family member 4
SNAI1 snail family zinc finger 1
SOD2 superoxide dismutase 2, mitochondrial
SOX9 SRY (sex determining region Y)-box 9
SP1 Sp1 transcription factor
SPP1 secreted phosphoprotein 1
SREBF1 sterol regulatory element binding transcription factor 1
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
SULT2A1 sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1
TFF2 trefoil factor 2
TFF3 trefoil factor 3 (intestinal)
TGFA transforming growth factor, alpha
TGFB1 transforming growth factor, beta 1
TJP2 tight junction protein 2
TLR4 toll-like receptor 4
TNF tumor necrosis factor
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TP53 tumor protein p53
TP63 tumor protein p63
TP73 tumor protein p73
TRIB3 tribbles pseudokinase 3
TXN thioredoxin
TYMP thymidine phosphorylase
UGT1A3 UDP glucuronosyltransferase 1 family, polypeptide A3
UGT2A3 UDP glucuronosyltransferase 2 family, polypeptide A3
UGT2B4 UDP glucuronosyltransferase 2 family, polypeptide B4
UGT8 UDP glycosyltransferase 8
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
VTCN1 V-set domain containing T cell activation inhibitor 1
XDH xanthine dehydrogenase