bipolar disorder Gene Set

Dataset GAD Gene-Disease Associations
Category disease or phenotype associations
Type disease
Description A mood disorder that involves alternating periods of mania and depression. (Human Disease Ontology, DOID_3312)
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Genes

295 genes associated with the disease bipolar disorder in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

Symbol Name
ACE angiotensin I converting enzyme
ACTR3B ARP3 actin-related protein 3 homolog B (yeast)
ADAM19 ADAM metallopeptidase domain 19
ADAMTS14 ADAM metallopeptidase with thrombospondin type 1 motif, 14
ADCY9 adenylate cyclase 9
ADCYAP1 adenylate cyclase activating polypeptide 1 (pituitary)
ADORA1 adenosine A1 receptor
ADRA1B adrenoceptor alpha 1B
AKT1 v-akt murine thymoma viral oncogene homolog 1
AKTIP AKT interacting protein
ALOX12 arachidonate 12-lipoxygenase
AMPH amphiphysin
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
ARNT2 aryl-hydrocarbon receptor nuclear translocator 2
ARNTL aryl hydrocarbon receptor nuclear translocator-like
ARNTL2 aryl hydrocarbon receptor nuclear translocator-like 2
ATP1A1 ATPase, Na+/K+ transporting, alpha 1 polypeptide
ATP1A2 ATPase, Na+/K+ transporting, alpha 2 polypeptide
ATP1A3 ATPase, Na+/K+ transporting, alpha 3 polypeptide
ATP4B ATPase, H+/K+ exchanging, beta polypeptide
ATP8B3 ATPase, aminophospholipid transporter, class I, type 8B, member 3
AUTS2 autism susceptibility candidate 2
B3GALT5 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 5
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein)
BDNF brain-derived neurotrophic factor
BHLHE40 basic helix-loop-helix family, member e40
BHLHE41 basic helix-loop-helix family, member e41
BRWD1 bromodomain and WD repeat domain containing 1
BSN bassoon presynaptic cytomatrix protein
BTBD16 BTB (POZ) domain containing 16
C11ORF80 chromosome 11 open reading frame 80
C15ORF32 chromosome 15 open reading frame 32
C15ORF53 chromosome 15 open reading frame 53
CACNA1C calcium channel, voltage-dependent, L type, alpha 1C subunit
CACNA2D4 calcium channel, voltage-dependent, alpha 2/delta subunit 4
CACNB3 calcium channel, voltage-dependent, beta 3 subunit
CACNG2 calcium channel, voltage-dependent, gamma subunit 2
CAMK2A calcium/calmodulin-dependent protein kinase II alpha
CAMKMT calmodulin-lysine N-methyltransferase
CAPN6 calpain 6
CCL2 chemokine (C-C motif) ligand 2
CDC25B cell division cycle 25B
CDH12 cadherin 12, type 2 (N-cadherin 2)
CENPC centromere protein C
CENPO centromere protein O
CGNL1 cingulin-like 1
CHMP1B charged multivesicular body protein 1B
CHRNA7 cholinergic receptor, nicotinic, alpha 7 (neuronal)
CIT citron rho-interacting serine/threonine kinase
CLOCK clock circadian regulator
CLSPN claspin
CMTM8 CKLF-like MARVEL transmembrane domain containing 8
CNTNAP2 contactin associated protein-like 2
CNTNAP5 contactin associated protein-like 5
COL28A1 collagen, type XXVIII, alpha 1
COMT catechol-O-methyltransferase
COX20 COX20 cytochrome c oxidase assembly factor
CRH corticotropin releasing hormone
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like)
CRY1 cryptochrome circadian clock 1
CRY2 cryptochrome circadian clock 2
CSNK1D casein kinase 1, delta
CSNK1E casein kinase 1, epsilon
CTNNA2 catenin (cadherin-associated protein), alpha 2
CTSF cathepsin F
CTSH cathepsin H
CUX2 cut-like homeobox 2
DAOA D-amino acid oxidase activator
DBP D site of albumin promoter (albumin D-box) binding protein
DCTN5 dynactin 5 (p25)
DFNB31 deafness, autosomal recessive 31
DGKH diacylglycerol kinase, eta
DIO2 deiodinase, iodothyronine, type II
DISC1 disrupted in schizophrenia 1
DLEU2 deleted in lymphocytic leukemia 2 (non-protein coding)
DMD dystrophin
DMTF1 cyclin D binding myb-like transcription factor 1
DOCK9 dedicator of cytokinesis 9
DPP10 dipeptidyl-peptidase 10 (non-functional)
DPY19L3 dpy-19-like 3 (C. elegans)
DPYSL2 dihydropyrimidinase-like 2
DRD1 dopamine receptor D1
DRD2 dopamine receptor D2
DRD3 dopamine receptor D3
DRD4 dopamine receptor D4
DSCAM Down syndrome cell adhesion molecule
DTNBP1 dystrobrevin binding protein 1
DUSP6 dual specificity phosphatase 6
ESR1 estrogen receptor 1
FAM126A family with sequence similarity 126, member A
FANCL Fanconi anemia, complementation group L
FANK1 fibronectin type III and ankyrin repeat domains 1
FAT1 FAT atypical cadherin 1
FAT4 FAT atypical cadherin 4
FBLN1 fibulin 1
FBN1 fibrillin 1
FKBP5 FK506 binding protein 5
FOXO6 forkhead box O6
FYN FYN proto-oncogene, Src family tyrosine kinase
FZD2 frizzled class receptor 2
GABBR2 gamma-aminobutyric acid (GABA) B receptor, 2
GABRA1 gamma-aminobutyric acid (GABA) A receptor, alpha 1
GABRA2 gamma-aminobutyric acid (GABA) A receptor, alpha 2
GABRA3 gamma-aminobutyric acid (GABA) A receptor, alpha 3
GABRA4 gamma-aminobutyric acid (GABA) A receptor, alpha 4
GABRA5 gamma-aminobutyric acid (GABA) A receptor, alpha 5
GABRA6 gamma-aminobutyric acid (GABA) A receptor, alpha 6
GABRB1 gamma-aminobutyric acid (GABA) A receptor, beta 1
GABRB2 gamma-aminobutyric acid (GABA) A receptor, beta 2
GABRB3 gamma-aminobutyric acid (GABA) A receptor, beta 3
GABRE gamma-aminobutyric acid (GABA) A receptor, epsilon
GABRG1 gamma-aminobutyric acid (GABA) A receptor, gamma 1
GABRG2 gamma-aminobutyric acid (GABA) A receptor, gamma 2
GABRG3 gamma-aminobutyric acid (GABA) A receptor, gamma 3
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GABRQ gamma-aminobutyric acid (GABA) A receptor, theta
GABRR1 gamma-aminobutyric acid (GABA) A receptor, rho 1
GABRR2 gamma-aminobutyric acid (GABA) A receptor, rho 2
GABRR3 gamma-aminobutyric acid (GABA) A receptor, rho 3 (gene/pseudogene)
GAD1 glutamate decarboxylase 1 (brain, 67kDa)
GARNL3 GTPase activating Rap/RanGAP domain-like 3
GNAL guanine nucleotide binding protein (G protein), alpha activating activity polypeptide, olfactory type
GNB3 guanine nucleotide binding protein (G protein), beta polypeptide 3
GNL3 guanine nucleotide binding protein-like 3 (nucleolar)
GPM6A glycoprotein M6A
GPR50 G protein-coupled receptor 50
GPR78 G protein-coupled receptor 78
GRIA1 glutamate receptor, ionotropic, AMPA 1
GRIA2 glutamate receptor, ionotropic, AMPA 2
GRIK4 glutamate receptor, ionotropic, kainate 4
GRIK5 glutamate receptor, ionotropic, kainate 5
GRIN1 glutamate receptor, ionotropic, N-methyl D-aspartate 1
GRIN2A glutamate receptor, ionotropic, N-methyl D-aspartate 2A
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B
GRIN2C glutamate receptor, ionotropic, N-methyl D-aspartate 2C
GRIN2D glutamate receptor, ionotropic, N-methyl D-aspartate 2D
GRM3 glutamate receptor, metabotropic 3
GRM4 glutamate receptor, metabotropic 4
GRM7 glutamate receptor, metabotropic 7
GSK3B glycogen synthase kinase 3 beta
GUCY1B2 guanylate cyclase 1, soluble, beta 2 (pseudogene)
HMGXB4 HMG box domain containing 4
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2)
HSPA4 heat shock 70kDa protein 4
HTR1B 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled
HTR2A 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled
HTR2C 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled
HTR3A 5-hydroxytryptamine (serotonin) receptor 3A, ionotropic
HTR3B 5-hydroxytryptamine (serotonin) receptor 3B, ionotropic
HTR4 5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled
HTR5A 5-hydroxytryptamine (serotonin) receptor 5A, G protein-coupled
IL1B interleukin 1, beta
IL1RN interleukin 1 receptor antagonist
INTS7 integrator complex subunit 7
IRF2 interferon regulatory factor 2
ITIH1 inter-alpha-trypsin inhibitor heavy chain 1
ITIH3 inter-alpha-trypsin inhibitor heavy chain 3
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2
JAM3 junctional adhesion molecule 3
KCNJ6 potassium channel, inwardly rectifying subfamily J, member 6
KCNN3 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 3
KIAA0355 KIAA0355
KIAA1033 KIAA1033
KIAA1211L KIAA1211-like
KIF13A kinesin family member 13A
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
LAMP3 lysosomal-associated membrane protein 3
LMAN2L lectin, mannose-binding 2-like
MAD1L1 MAD1 mitotic arrest deficient-like 1 (yeast)
MAMDC2 MAM domain containing 2
MAOA monoamine oxidase A
MAOB monoamine oxidase B
MARCH5 membrane-associated ring finger (C3HC4) 5
MCHR2 melanin-concentrating hormone receptor 2
MCTP1 multiple C2 domains, transmembrane 1
MGAT4A mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A
MPPE1 metallophosphoesterase 1
MT-ND2 MTND2
MT-ND5 NADH dehydrogenase, subunit 5 (complex I)
MTHFD1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
MTR 5-methyltetrahydrofolate-homocysteine methyltransferase
NALCN sodium leak channel, non selective
NAPG N-ethylmaleimide-sensitive factor attachment protein, gamma
NCAM1 neural cell adhesion molecule 1
NCAN neurocan
NCKAP5 NCK-associated protein 5
NCOR2 nuclear receptor corepressor 2
NDUFAB1 NADH dehydrogenase (ubiquinone) 1, alpha/beta subcomplex, 1, 8kDa
NDUFV2 NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa
NEK4 NIMA-related kinase 4
NFIX nuclear factor I/X (CCAAT-binding transcription factor)
NOS1 nitric oxide synthase 1 (neuronal)
NOS3 nitric oxide synthase 3 (endothelial cell)
NPAS2 neuronal PAS domain protein 2
NPAS3 neuronal PAS domain protein 3
NR1D1 nuclear receptor subfamily 1, group D, member 1
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NRG1 neuregulin 1
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
NTS neurotensin
NXN nucleoredoxin
P2RX7 purinergic receptor P2X, ligand gated ion channel, 7
PALB2 partner and localizer of BRCA2
PBRM1 polybromo 1
PCBP3 poly(rC) binding protein 3
PCNT pericentrin
PDLIM5 PDZ and LIM domain 5
PENK proenkephalin
PER1 period circadian clock 1
PER3 period circadian clock 3
PI4K2B phosphatidylinositol 4-kinase type 2 beta
PI4KA phosphatidylinositol 4-kinase, catalytic, alpha
PIP4K2A phosphatidylinositol-5-phosphate 4-kinase, type II, alpha
PKIA protein kinase (cAMP-dependent, catalytic) inhibitor alpha
PLCG1 phospholipase C, gamma 1
PLCG2 phospholipase C, gamma 2 (phosphatidylinositol-specific)
PPARD peroxisome proliferator-activated receptor delta
PPM1M protein phosphatase, Mg2+/Mn2+ dependent, 1M
PRKAG2 protein kinase, AMP-activated, gamma 2 non-catalytic subunit
PRSS3 protease, serine, 3
PTPRG protein tyrosine phosphatase, receptor type, G
PTPRQ protein tyrosine phosphatase, receptor type, Q
PTRHD1 peptidyl-tRNA hydrolase domain containing 1
QDPR quinoid dihydropteridine reductase
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated)
RASIP1 Ras interacting protein 1
RBFOX1 RNA binding protein, fox-1 homolog (C. elegans) 1
RELN reelin
RFX4 regulatory factor X, 4 (influences HLA class II expression)
RGS4 regulator of G-protein signaling 4
RGS5 regulator of G-protein signaling 5
RNPEPL1 arginyl aminopeptidase (aminopeptidase B)-like 1
ROR1 receptor tyrosine kinase-like orphan receptor 1
RORA RAR-related orphan receptor A
RORB RAR-related orphan receptor B
RPRD1B regulation of nuclear pre-mRNA domain containing 1B
SCN8A sodium channel, voltage gated, type VIII alpha subunit
SGOL1 shugoshin-like 1 (S. pombe)
SIAE sialic acid acetylesterase
SLC18A2 solute carrier family 18 (vesicular monoamine transporter), member 2
SLC22A6 solute carrier family 22 (organic anion transporter), member 6
SLC35F4 solute carrier family 35, member F4
SLC39A3 solute carrier family 39 (zinc transporter), member 3
SLC6A3 solute carrier family 6 (neurotransmitter transporter), member 3
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4
SLITRK2 SLIT and NTRK-like family, member 2
SMIM21 small integral membrane protein 21
SMYD3 SET and MYND domain containing 3
SNAP25 synaptosomal-associated protein, 25kDa
SORCS2 sortilin-related VPS10 domain containing receptor 2
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SP4 Sp4 transcription factor
SPR sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase)
SPTBN1 spectrin, beta, non-erythrocytic 1
SST somatostatin
STK24 serine/threonine kinase 24
SVEP1 sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1
SYNE1 spectrin repeat containing, nuclear envelope 1
SYNJ1 synaptojanin 1
TAAR6 trace amine associated receptor 6
TBC1D15 TBC1 domain family, member 15
TCF7L1 transcription factor 7-like 1 (T-cell specific, HMG-box)
TDRD9 tudor domain containing 9
TENM4 teneurin transmembrane protein 4
TH tyrosine hydroxylase
THSD7A thrombospondin, type I, domain containing 7A
TIAM2 T-cell lymphoma invasion and metastasis 2
TIMELESS timeless circadian clock
TLE4 transducin-like enhancer of split 4
TNF tumor necrosis factor
TOM1 target of myb1 (chicken)
TPH1 tryptophan hydroxylase 1
TPH2 tryptophan hydroxylase 2
TRDN triadin
TRPC7 transient receptor potential cation channel, subfamily C, member 7
TRPM2 transient receptor potential cation channel, subfamily M, member 2
VAMP2 vesicle-associated membrane protein 2 (synaptobrevin 2)
VAMP3 vesicle-associated membrane protein 3
VAPA VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa
VGLL4 vestigial-like family member 4
VIP vasoactive intestinal peptide
VIPR1 vasoactive intestinal peptide receptor 1
VRK2 vaccinia related kinase 2
VWA8 von Willebrand factor A domain containing 8
WNT2B wingless-type MMTV integration site family, member 2B
WNT7A wingless-type MMTV integration site family, member 7A
WSCD2 WSC domain containing 2
WWOX WW domain containing oxidoreductase
XBP1 X-box binding protein 1
YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta
ZMAT4 zinc finger, matrin-type 4
ZMIZ1 zinc finger, MIZ-type containing 1
ZNF385D zinc finger protein 385D
ZNF490 zinc finger protein 490