blockade Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
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Genes

302 genes co-occuring with the biological term blockade in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ACE angiotensin I converting enzyme
ACE2 angiotensin I converting enzyme 2
ADAM17 ADAM metallopeptidase domain 17
ADORA2B adenosine A2b receptor
ADRA1A adrenoceptor alpha 1A
ADRA2B adrenoceptor alpha 2B
ADRB1 adrenoceptor beta 1
ADRB2 adrenoceptor beta 2, surface
AGER advanced glycosylation end product-specific receptor
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AGTR1 angiotensin II receptor, type 1
AKT1 v-akt murine thymoma viral oncogene homolog 1
ALK anaplastic lymphoma receptor tyrosine kinase
ANGPT1 angiopoietin 1
ANGPT2 angiopoietin 2
ANGPTL2 angiopoietin-like 2
AOC3 amine oxidase, copper containing 3
APOC1 apolipoprotein C-I
APP amyloid beta (A4) precursor protein
AREG amphiregulin
ATF1 activating transcription factor 1
ATM ATM serine/threonine kinase
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2
ATPIF1 ATPase inhibitory factor 1
BAX BCL2-associated X protein
BDKRB2 bradykinin receptor B2
BDNF brain-derived neurotrophic factor
BIRC5 baculoviral IAP repeat containing 5
BMP2 bone morphogenetic protein 2
BRAF B-Raf proto-oncogene, serine/threonine kinase
BRCA1 breast cancer 1, early onset
BTLA B and T lymphocyte associated
C5 complement component 5
CALCA calcitonin-related polypeptide alpha
CASP8 caspase 8, apoptosis-related cysteine peptidase
CCL17 chemokine (C-C motif) ligand 17
CCL5 chemokine (C-C motif) ligand 5
CCR5 chemokine (C-C motif) receptor 5 (gene/pseudogene)
CD14 CD14 molecule
CD200 CD200 molecule
CD244 CD244 molecule, natural killer cell receptor 2B4
CD247 CD247 molecule
CD274 CD274 molecule
CD28 CD28 molecule
CD40 CD40 molecule, TNF receptor superfamily member 5
CD40LG CD40 ligand
CD44 CD44 molecule (Indian blood group)
CD47 CD47 molecule
CD48 CD48 molecule
CD80 CD80 molecule
CDK2 cyclin-dependent kinase 2
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CETP cholesteryl ester transfer protein, plasma
CFLAR CASP8 and FADD-like apoptosis regulator
CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHRD chordin
CLEC5A C-type lectin domain family 5, member A
CNR1 cannabinoid receptor 1 (brain)
COL1A2 collagen, type I, alpha 2
CRP C-reactive protein, pentraxin-related
CRTC1 CREB regulated transcription coactivator 1
CSF2RA colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage)
CSPG4 chondroitin sulfate proteoglycan 4
CTLA4 cytotoxic T-lymphocyte-associated protein 4
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CTSB cathepsin B
CTSS cathepsin S
CXCL12 chemokine (C-X-C motif) ligand 12
CXCL5 chemokine (C-X-C motif) ligand 5
CXCL8 chemokine (C-X-C motif) ligand 8
CXCR1 chemokine (C-X-C motif) receptor 1
CXCR2 chemokine (C-X-C motif) receptor 2
CXCR4 chemokine (C-X-C motif) receptor 4
DEFB4A defensin, beta 4A
DGKE diacylglycerol kinase, epsilon 64kDa
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLL4 delta-like 4 (Drosophila)
DRD1 dopamine receptor D1
DRD2 dopamine receptor D2
DRD4 dopamine receptor D4
EDN1 endothelin 1
EDNRA endothelin receptor type A
EDNRB endothelin receptor type B
EGF epidermal growth factor
EGFR epidermal growth factor receptor
EPHA2 EPH receptor A2
EPO erythropoietin
ERBB2 erb-b2 receptor tyrosine kinase 2
ERBB3 erb-b2 receptor tyrosine kinase 3
EREG epiregulin
ESR1 estrogen receptor 1
F2RL1 coagulation factor II (thrombin) receptor-like 1
FAAH fatty acid amide hydrolase
FAS Fas cell surface death receptor
FASN fatty acid synthase
FCGR2B Fc fragment of IgG, low affinity IIb, receptor (CD32)
FCGRT Fc fragment of IgG, receptor, transporter, alpha
FGF2 fibroblast growth factor 2 (basic)
FGF23 fibroblast growth factor 23
FGFR1 fibroblast growth factor receptor 1
FMOD fibromodulin
FMR1 fragile X mental retardation 1
FOXO3 forkhead box O3
FST follistatin
FYB FYN binding protein
GABBR1 gamma-aminobutyric acid (GABA) B receptor, 1
GATA3 GATA binding protein 3
GDF2 growth differentiation factor 2
GJA1 gap junction protein, alpha 1, 43kDa
GNB2L1 guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1
GP6 glycoprotein VI (platelet)
GPBAR1 G protein-coupled bile acid receptor 1
GRK5 G protein-coupled receptor kinase 5
GRM5 glutamate receptor, metabotropic 5
GZMB granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)
HAMP hepcidin antimicrobial peptide
HAVCR2 hepatitis A virus cellular receptor 2
HDAC2 histone deacetylase 2
HGF hepatocyte growth factor (hepapoietin A; scatter factor)
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HMGB1 high mobility group box 1
HMOX1 heme oxygenase 1
HRK harakiri, BCL2 interacting protein
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
ICAM1 intercellular adhesion molecule 1
ICOS inducible T-cell co-stimulator
IDO1 indoleamine 2,3-dioxygenase 1
IER3 immediate early response 3
IFIH1 interferon induced with helicase C domain 1
IFN1@ interferon, type 1, cluster
IFNA1 interferon, alpha 1
IFNB1 interferon, beta 1, fibroblast
IFNG interferon, gamma
IFNGR1 interferon gamma receptor 1
IGF1R insulin-like growth factor 1 receptor
IL10 interleukin 10
IL12A interleukin 12A
IL12B interleukin 12B
IL13 interleukin 13
IL17A interleukin 17A
IL18 interleukin 18
IL1A interleukin 1, alpha
IL1B interleukin 1, beta
IL1RN interleukin 1 receptor antagonist
IL21 interleukin 21
IL21R interleukin 21 receptor
IL4 interleukin 4
IL6 interleukin 6
IL6R interleukin 6 receptor
IRAK1 interleukin-1 receptor-associated kinase 1
IRAK4 interleukin-1 receptor-associated kinase 4
IRF3 interferon regulatory factor 3
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
ITGA6 integrin, alpha 6
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit)
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
JAM3 junctional adhesion molecule 3
JUN jun proto-oncogene
KCNA3 potassium channel, voltage gated shaker related subfamily A, member 3
KCNA5 potassium channel, voltage gated shaker related subfamily A, member 5
KCNH2 potassium channel, voltage gated eag related subfamily H, member 2
KCNIP3 Kv channel interacting protein 3, calsenilin
KCNIP4 Kv channel interacting protein 4
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
KCNQ1 potassium channel, voltage gated KQT-like subfamily Q, member 1
KDR kinase insert domain receptor
KISS1 KiSS-1 metastasis-suppressor
KLLN killin, p53-regulated DNA replication inhibitor
KLRG1 killer cell lectin-like receptor subfamily G, member 1
KLRK1 killer cell lectin-like receptor subfamily K, member 1
KRAS Kirsten rat sarcoma viral oncogene homolog
LEP leptin
LGALS3 lectin, galactoside-binding, soluble, 3
LHB luteinizing hormone beta polypeptide
LILRB1 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1
LILRB3 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3
LTB4R leukotriene B4 receptor
LTB4R2 leukotriene B4 receptor 2
LTBR lymphotoxin beta receptor (TNFR superfamily, member 3)
MAP2K1 mitogen-activated protein kinase kinase 1
MAPK1 mitogen-activated protein kinase 1
MAPK14 mitogen-activated protein kinase 14
MAPK3 mitogen-activated protein kinase 3
MCAM melanoma cell adhesion molecule
MCL1 myeloid cell leukemia 1
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MEN1 multiple endocrine neoplasia I
MESP1 mesoderm posterior basic helix-loop-helix transcription factor 1
MET MET proto-oncogene, receptor tyrosine kinase
MFGE8 milk fat globule-EGF factor 8 protein
MIF macrophage migration inhibitory factor (glycosylation-inhibiting factor)
MIR132 microRNA 132
MIR149 microRNA 149
MIR210 microRNA 210
MIR32 microRNA 32
MMP14 matrix metallopeptidase 14 (membrane-inserted)
MMP2 matrix metallopeptidase 2
MMP3 matrix metallopeptidase 3
MMP9 matrix metallopeptidase 9
MTOR mechanistic target of rapamycin (serine/threonine kinase)
MUC16 mucin 16, cell surface associated
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYD88 myeloid differentiation primary response 88
NCR3 natural cytotoxicity triggering receptor 3
NFE2L2 nuclear factor, erythroid 2-like 2
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NOD2 nucleotide-binding oligomerization domain containing 2
NOS3 nitric oxide synthase 3 (endothelial cell)
NOTCH1 notch 1
NOX4 NADPH oxidase 4
NPPC natriuretic peptide C
NR3C2 nuclear receptor subfamily 3, group C, member 2
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
OLR1 oxidized low density lipoprotein (lectin-like) receptor 1
P2RX7 purinergic receptor P2X, ligand gated ion channel, 7
P2RY1 purinergic receptor P2Y, G-protein coupled, 1
P2RY12 purinergic receptor P2Y, G-protein coupled, 12
PARK2 parkin RBR E3 ubiquitin protein ligase
PBK PDZ binding kinase
PDCD1 programmed cell death 1
PDCD1LG2 programmed cell death 1 ligand 2
PDGFB platelet-derived growth factor beta polypeptide
PF4 platelet factor 4
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta
PINK1 PTEN induced putative kinase 1
PLA2G10 phospholipase A2, group X
POLB polymerase (DNA directed), beta
POMC proopiomelanocortin
POU2F1 POU class 2 homeobox 1
PPARG peroxisome proliferator-activated receptor gamma
PRDX1 peroxiredoxin 1
PRKCD protein kinase C, delta
PRKCE protein kinase C, epsilon
PRKCG protein kinase C, gamma
PRKDC protein kinase, DNA-activated, catalytic polypeptide
PRLR prolactin receptor
PROM1 prominin 1
PTEN phosphatase and tensin homolog
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTPN6 protein tyrosine phosphatase, non-receptor type 6
PTPRZ1 protein tyrosine phosphatase, receptor-type, Z polypeptide 1
PTX3 pentraxin 3, long
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
RAP1A RAP1A, member of RAS oncogene family
REN renin
RHOJ ras homolog family member J
ROCK1 Rho-associated, coiled-coil containing protein kinase 1
S100B S100 calcium binding protein B
SELL selectin L
SELPLG selectin P ligand
SEPT9 septin 9
SFRP1 secreted frizzled-related protein 1
SIRPA signal-regulatory protein alpha
SIRT1 sirtuin 1
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC22A4 solute carrier family 22 (organic cation/zwitterion transporter), member 4
SMAD3 SMAD family member 3
SNCG synuclein, gamma (breast cancer-specific protein 1)
SOD3 superoxide dismutase 3, extracellular
SREBF1 sterol regulatory element binding transcription factor 1
STAT2 signal transducer and activator of transcription 2, 113kDa
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
SYK spleen tyrosine kinase
TERT telomerase reverse transcriptase
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TGFB1 transforming growth factor, beta 1
TGFB2 transforming growth factor, beta 2
TGFB3 transforming growth factor, beta 3
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TLR2 toll-like receptor 2
TLR4 toll-like receptor 4
TLR9 toll-like receptor 9
TLX1 T-cell leukemia homeobox 1
TNF tumor necrosis factor
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TNFRSF1B tumor necrosis factor receptor superfamily, member 1B
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TNFSF14 tumor necrosis factor (ligand) superfamily, member 14
TOMM22 translocase of outer mitochondrial membrane 22 homolog (yeast)
TOMM40 translocase of outer mitochondrial membrane 40 homolog (yeast)
TOMM70A translocase of outer mitochondrial membrane 70 homolog A (S. cerevisiae)
TP53 tumor protein p53
TRPA1 transient receptor potential cation channel, subfamily A, member 1
TRPM8 transient receptor potential cation channel, subfamily M, member 8
TRPV1 transient receptor potential cation channel, subfamily V, member 1
TSLP thymic stromal lymphopoietin
TSPO translocator protein (18kDa)
UNC93B1 unc-93 homolog B1 (C. elegans)
VASP vasodilator-stimulated phosphoprotein
VCAM1 vascular cell adhesion molecule 1
VEGFA vascular endothelial growth factor A
WISP3 WNT1 inducible signaling pathway protein 3
WNT1 wingless-type MMTV integration site family, member 1
WNT3A wingless-type MMTV integration site family, member 3A