boldine-4004 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

198 genes differentially expressed following the boldine-4004 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2
ACRV1 acrosomal vesicle protein 1
ACSBG1 acyl-CoA synthetase bubblegum family member 1
ADRA1A adrenoceptor alpha 1A
AKR1C4 aldo-keto reductase family 1, member C4
ANKRD2 ankyrin repeat domain 2 (stretch responsive muscle)
AREG amphiregulin
ASCL1 achaete-scute family bHLH transcription factor 1
ATF7IP activating transcription factor 7 interacting protein
B3GALT2 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 2
BTG2 BTG family, member 2
BTRC beta-transducin repeat containing E3 ubiquitin protein ligase
C10ORF12 chromosome 10 open reading frame 12
C14ORF1 chromosome 14 open reading frame 1
C8A complement component 8, alpha polypeptide
CCK cholecystokinin
CCND2 cyclin D2
CCR7 chemokine (C-C motif) receptor 7
CD160 CD160 molecule
CD209 CD209 molecule
CD33 CD33 molecule
CD6 CD6 molecule
CDY1 chromodomain protein, Y-linked, 1
CHN2 chimerin 2
CLDN18 claudin 18
CORO2B coronin, actin binding protein, 2B
CSHL1 chorionic somatomammotropin hormone-like 1
CXCL8 chemokine (C-X-C motif) ligand 8
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5
DDO D-aspartate oxidase
DLG2 discs, large homolog 2 (Drosophila)
DRP2 dystrophin related protein 2
EML2 echinoderm microtubule associated protein like 2
FCGR2C Fc fragment of IgG, low affinity IIc, receptor for (CD32) (gene/pseudogene)
GFI1 growth factor independent 1 transcription repressor
GRIA3 glutamate receptor, ionotropic, AMPA 3
GRIK2 glutamate receptor, ionotropic, kainate 2
HEG1 heart development protein with EGF-like domains 1
HNF1B HNF1 homeobox B
HOXD13 homeobox D13
HS6ST1 heparan sulfate 6-O-sulfotransferase 1
IL12B interleukin 12B
IL6 interleukin 6
KANSL3 KAT8 regulatory NSL complex subunit 3
KCND3 potassium channel, voltage gated Shal related subfamily D, member 3
KCNJ1 potassium channel, inwardly rectifying subfamily J, member 1
KIAA0087 KIAA0087
KIF25-AS1 KIF25 antisense RNA 1
KLF13 Kruppel-like factor 13
LENEP lens epithelial protein
LGALS8 lectin, galactoside-binding, soluble, 8
LINC00115 long intergenic non-protein coding RNA 115
LLGL1 lethal giant larvae homolog 1 (Drosophila)
LUZP4 leucine zipper protein 4
MAG myelin associated glycoprotein
MAP3K13 mitogen-activated protein kinase kinase kinase 13
MAPK10 mitogen-activated protein kinase 10
MAU2 MAU2 sister chromatid cohesion factor
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10
MUC2 mucin 2, oligomeric mucus/gel-forming
MYH11 myosin, heavy chain 11, smooth muscle
N4BP2L1 NEDD4 binding protein 2-like 1
NAV3 neuron navigator 3
NEK1 NIMA-related kinase 1
NHLH2 nescient helix loop helix 2
NMUR1 neuromedin U receptor 1
OBSL1 obscurin-like 1
OR12D3 olfactory receptor, family 12, subfamily D, member 3
PADI4 peptidyl arginine deiminase, type IV
PCSK5 proprotein convertase subtilisin/kexin type 5
PEX5L peroxisomal biogenesis factor 5-like
PGM5 phosphoglucomutase 5
PITX2 paired-like homeodomain 2
PIWIL1 piwi-like RNA-mediated gene silencing 1
PLA2G5 phospholipase A2, group V
PNPLA2 patatin-like phospholipase domain containing 2
POU6F2 POU class 6 homeobox 2
PPIAL4A peptidylprolyl isomerase A (cyclophilin A)-like 4A
PPIL2 peptidylprolyl isomerase (cyclophilin)-like 2
PRDM9 PR domain containing 9
PROX1 prospero homeobox 1
PSG9 pregnancy specific beta-1-glycoprotein 9
RIMS2 regulating synaptic membrane exocytosis 2
RPL35A ribosomal protein L35a
SGCD sarcoglycan, delta (35kDa dystrophin-associated glycoprotein)
SIGLEC8 sialic acid binding Ig-like lectin 8
SLC12A5 solute carrier family 12 (potassium/chloride transporter), member 5
SLC26A3 solute carrier family 26 (anion exchanger), member 3
SLC39A9 solute carrier family 39, member 9
SLC44A1 solute carrier family 44 (choline transporter), member 1
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6
SLMO1 slowmo homolog 1 (Drosophila)
TBX2 T-box 2
TLX2 T-cell leukemia homeobox 2
TMEM212 transmembrane protein 212
TNNT3 troponin T type 3 (skeletal, fast)
TP53AIP1 tumor protein p53 regulated apoptosis inducing protein 1
TREM1 triggering receptor expressed on myeloid cells 1
TUBA3C tubulin, alpha 3c
UGT2B17 UDP glucuronosyltransferase 2 family, polypeptide B17

decreased expression

Symbol Name
ABCB8 ATP-binding cassette, sub-family B (MDR/TAP), member 8
AEN apoptosis enhancing nuclease
ANKFY1 ankyrin repeat and FYVE domain containing 1
ARL14 ADP-ribosylation factor-like 14
ARPIN actin-related protein 2/3 complex inhibitor
AXIN1 axin 1
BGLAP bone gamma-carboxyglutamate (gla) protein
C16ORF59 chromosome 16 open reading frame 59
C1ORF105 chromosome 1 open reading frame 105
CA5BP1 carbonic anhydrase VB pseudogene 1
CA9 carbonic anhydrase IX
CAMK1 calcium/calmodulin-dependent protein kinase I
CCNO cyclin O
CHMP6 charged multivesicular body protein 6
CLDN4 claudin 4
CNNM4 cyclin and CBS domain divalent metal cation transport mediator 4
CRYBB2P1 crystallin, beta B2 pseudogene 1
CTDP1 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1
CUZD1 CUB and zona pellucida-like domains 1
DDX31 DEAD (Asp-Glu-Ala-Asp) box polypeptide 31
DNAL4 dynein, axonemal, light chain 4
ECM1 extracellular matrix protein 1
EFNA3 ephrin-A3
EMP3 epithelial membrane protein 3
EPHX2 epoxide hydrolase 2, cytoplasmic
EPN1 epsin 1
ERO1LB ERO1-like beta (S. cerevisiae)
EXOC6B exocyst complex component 6B
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
GDAP1 ganglioside induced differentiation associated protein 1
GLTSCR1 glioma tumor suppressor candidate region gene 1
GPATCH2L G patch domain containing 2-like
HDAC7 histone deacetylase 7
HIST1H3C histone cluster 1, H3c
HSF2BP heat shock transcription factor 2 binding protein
HSPB6 heat shock protein, alpha-crystallin-related, B6
IFI35 interferon-induced protein 35
IFI6 interferon, alpha-inducible protein 6
IFT54 intraflagellar transport 54
IL11RA interleukin 11 receptor, alpha
IL17RB interleukin 17 receptor B
ISL1 ISL LIM homeobox 1
LPPR4 lipid phosphate phosphatase-related protein type 4
LY6G5C lymphocyte antigen 6 complex, locus G5C
LYPD3 LY6/PLAUR domain containing 3
MAST3 microtubule associated serine/threonine kinase 3
MCC mutated in colorectal cancers
MFSD10 major facilitator superfamily domain containing 10
NDP Norrie disease (pseudoglioma)
NR1H3 nuclear receptor subfamily 1, group H, member 3
NT5M 5',3'-nucleotidase, mitochondrial
PAK3 p21 protein (Cdc42/Rac)-activated kinase 3
PALMD palmdelphin
PARD6A par-6 family cell polarity regulator alpha
PCYT2 phosphate cytidylyltransferase 2, ethanolamine
PIM1 Pim-1 proto-oncogene, serine/threonine kinase
PIP prolactin-induced protein
PLD3 phospholipase D family, member 3
PLEKHO1 pleckstrin homology domain containing, family O member 1
POR P450 (cytochrome) oxidoreductase
PRPH peripherin
PRR15L proline rich 15-like
PSKH1 protein serine kinase H1
PTGFR prostaglandin F receptor (FP)
PTK7 protein tyrosine kinase 7 (inactive)
QSER1 glutamine and serine rich 1
RAB17 RAB17, member RAS oncogene family
RALGDS ral guanine nucleotide dissociation stimulator
RNF126P1 ring finger protein 126 pseudogene 1
RNPEPL1 arginyl aminopeptidase (aminopeptidase B)-like 1
RPH3AL rabphilin 3A-like (without C2 domains)
RPL13P5 ribosomal protein L13 pseudogene 5
S100A3 S100 calcium binding protein A3
S100A4 S100 calcium binding protein A4
SAYSD1 SAYSVFN motif domain containing 1
SETD8 SET domain containing (lysine methyltransferase) 8
SFT2D2 SFT2 domain containing 2
SLAMF7 SLAM family member 7
SLC16A6 solute carrier family 16, member 6
SLC6A9 solute carrier family 6 (neurotransmitter transporter, glycine), member 9
SMARCD3 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3
SMUG1 single-strand-selective monofunctional uracil-DNA glycosylase 1
SSTR4 somatostatin receptor 4
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
STARD5 StAR-related lipid transfer (START) domain containing 5
TBC1D8B TBC1 domain family, member 8B (with GRAM domain)
TMEM8A transmembrane protein 8A
TRIM25 tripartite motif containing 25
TSKU tsukushi, small leucine rich proteoglycan
TXK TXK tyrosine kinase
TXLNG taxilin gamma
USP18 ubiquitin specific peptidase 18
WFDC2 WAP four-disulfide core domain 2
ZMAT5 zinc finger, matrin-type 5
ZNF141 zinc finger protein 141
ZNF276 zinc finger protein 276
ZNF324 zinc finger protein 324
ZNF528 zinc finger protein 528