bph Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description A non-cancerous nodular enlargement of the prostate gland. It is characterized by the presence of epithelial cell nodules, and stromal nodules containing fibrous and smooth muscle elements. It is the most common urologic disorder in men, causing blockage of urine flow.|A disease caused by hyperplastic process of non-transformed prostatic cells.|Increase in constituent cells in the PROSTATE, leading to enlargement of the organ (hypertrophy) and adverse impact on the lower urinary tract function. This can be caused by increased rate of cell proliferation, reduced rate of cell death, or both. (Experimental Factor Ontology, EFO_0000284)
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Genes

59 genes co-occuring with the biological term bph in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ACHE acetylcholinesterase (Yt blood group)
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ADAMTS15 ADAM metallopeptidase with thrombospondin type 1 motif, 15
ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif, 5
ADAMTS9 ADAM metallopeptidase with thrombospondin type 1 motif, 9
ADIPOQ adiponectin, C1Q and collagen domain containing
AIM2 absent in melanoma 2
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
AR androgen receptor
AURKA aurora kinase A
AURKB aurora kinase B
AURKC aurora kinase C
BCHE butyrylcholinesterase
BIRC2 baculoviral IAP repeat containing 2
BIRC3 baculoviral IAP repeat containing 3
CCR5 chemokine (C-C motif) receptor 5 (gene/pseudogene)
CSN1S1 casein alpha s1
CST3 cystatin C
DKK3 dickkopf WNT signaling pathway inhibitor 3
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EGFR epidermal growth factor receptor
ERG v-ets avian erythroblastosis virus E26 oncogene homolog
F2R coagulation factor II (thrombin) receptor
GSTM1 glutathione S-transferase mu 1
HCRT hypocretin (orexin) neuropeptide precursor
HCRTR2 hypocretin (orexin) receptor 2
HMGB1 high mobility group box 1
IGF1 insulin-like growth factor 1 (somatomedin C)
IGFBP3 insulin-like growth factor binding protein 3
IL10 interleukin 10
IL10RB interleukin 10 receptor, beta
IL1RN interleukin 1 receptor antagonist
IL4 interleukin 4
KLK11 kallikrein-related peptidase 11
KLK3 kallikrein-related peptidase 3
LEMD1 LEM domain containing 1
LTBP1 latent transforming growth factor beta binding protein 1
MLH1 mutL homolog 1
MSH2 mutS homolog 2
MT1A metallothionein 1A
MT2A metallothionein 2A
MT3 metallothionein 3
PMS2 PMS2 postmeiotic segregation increased 2 (S. cerevisiae)
PRF1 perforin 1 (pore forming protein)
PRSS1 protease, serine, 1 (trypsin 1)
PSCA prostate stem cell antigen
SIM2 single-minded family bHLH transcription factor 2
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1
SOD2 superoxide dismutase 2, mitochondrial
SPATA19 spermatogenesis associated 19
SRD5A2 steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2)
TGFB1 transforming growth factor, beta 1
TGM4 transglutaminase 4
TIMP3 TIMP metallopeptidase inhibitor 3
TRPV6 transient receptor potential cation channel, subfamily V, member 6
UBC ubiquitin C
VCAN versican
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
ZBTB7A zinc finger and BTB domain containing 7A