braf Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description B-Raf proto-oncogene, serine/threonine kinase|This gene encodes a protein belonging to the raf/mil family of serine/threonine protein kinases. This protein plays a role in regulating the MAP kinase/ERKs signaling pathway, which affects cell division, differentiation, and secretion. Mutations in this gene are associated with cardiofaciocutaneous syndrome, a disease characterized by heart defects, mental retardation and a distinctive facial appearance. Mutations in this gene have also been associated with various cancers, including non-Hodgkin lymphoma, colorectal cancer, malignant melanoma, thyroid carcinoma, non-small cell lung carcinoma, and adenocarcinoma of lung. A pseudogene, which is located on chromosome X, has been identified for this gene. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 673)
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Genes

149 genes co-occuring with the biological term braf in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
AGTR1 angiotensin II receptor, type 1
AICDA activation-induced cytidine deaminase
AKAP9 A kinase (PRKA) anchor protein 9
AKT1 v-akt murine thymoma viral oncogene homolog 1
AKT3 v-akt murine thymoma viral oncogene homolog 3
ALK anaplastic lymphoma receptor tyrosine kinase
APC adenomatous polyposis coli
ARAF A-Raf proto-oncogene, serine/threonine kinase
AXIN1 axin 1
AXIN2 axin 2
BAD BCL2-associated agonist of cell death
BAG3 BCL2-associated athanogene 3
BAP1 BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase)
BCL2 B-cell CLL/lymphoma 2
BCL2L11 BCL2-like 11 (apoptosis facilitator)
BDNF brain-derived neurotrophic factor
BRAF B-Raf proto-oncogene, serine/threonine kinase
CCDC6 coiled-coil domain containing 6
CCL4 chemokine (C-C motif) ligand 4
CCND1 cyclin D1
CD200 CD200 molecule
CDC42 cell division cycle 42
CDK1 cyclin-dependent kinase 1
CDK4 cyclin-dependent kinase 4
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CDKN2A cyclin-dependent kinase inhibitor 2A
CST6 cystatin E/M
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CXCL14 chemokine (C-X-C motif) ligand 14
CXCL8 chemokine (C-X-C motif) ligand 8
CXCR4 chemokine (C-X-C motif) receptor 4
DAPK1 death-associated protein kinase 1
DEFB4A defensin, beta 4A
DHRS3 dehydrogenase/reductase (SDR family) member 3
DNMT1 DNA (cytosine-5-)-methyltransferase 1
DUSP4 dual specificity phosphatase 4
EDNRB endothelin receptor type B
EGFR epidermal growth factor receptor
EP300 E1A binding protein p300
ERBB2 erb-b2 receptor tyrosine kinase 2
ERRFI1 ERBB receptor feedback inhibitor 1
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
FGFR3 fibroblast growth factor receptor 3
FOXD3 forkhead box D3
GABPB1 GA binding protein transcription factor, beta subunit 1
GNAQ guanine nucleotide binding protein (G protein), q polypeptide
GNAS GNAS complex locus
HGF hepatocyte growth factor (hepapoietin A; scatter factor)
HIPK2 homeodomain interacting protein kinase 2
HPSE heparanase
HRAS Harvey rat sarcoma viral oncogene homolog
HSPD1 heat shock 60kDa protein 1 (chaperonin)
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble
IFNG interferon, gamma
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IGFBP7 insulin-like growth factor binding protein 7
IGH immunoglobulin heavy locus
IL2 interleukin 2
IQGAP1 IQ motif containing GTPase activating protein 1
KIAA1549 KIAA1549
KIDINS220 kinase D-interacting substrate, 220kDa
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
KLF6 Kruppel-like factor 6
KRAS Kirsten rat sarcoma viral oncogene homolog
KRT19 keratin 19, type I
KRT20 keratin 20, type I
KRT7 keratin 7, type II
KSR1 kinase suppressor of ras 1
MAP2K1 mitogen-activated protein kinase kinase 1
MAP2K2 mitogen-activated protein kinase kinase 2
MAP3K11 mitogen-activated protein kinase kinase kinase 11
MAPK1 mitogen-activated protein kinase 1
MAPK3 mitogen-activated protein kinase 3
MAPK6 mitogen-activated protein kinase 6
MC1R melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)
MCL1 myeloid cell leukemia 1
MDK midkine (neurite growth-promoting factor 2)
MEIS1 Meis homeobox 1
MIR31 microRNA 31
MITF microphthalmia-associated transcription factor
MKI67 marker of proliferation Ki-67
MLH1 mutL homolog 1
MMP1 matrix metallopeptidase 1
MRAS muscle RAS oncogene homolog
MSH2 mutS homolog 2
MSH6 mutS homolog 6
MTOR mechanistic target of rapamycin (serine/threonine kinase)
MYC v-myc avian myelocytomatosis viral oncogene homolog
NCOA4 nuclear receptor coactivator 4
NF1 neurofibromin 1
NF2 neurofibromin 2 (merlin)
NRAS neuroblastoma RAS viral (v-ras) oncogene homolog
PAK1 p21 protein (Cdc42/Rac)-activated kinase 1
PAQR3 progestin and adipoQ receptor family member III
PDE5A phosphodiesterase 5A, cGMP-specific
PDGFA platelet-derived growth factor alpha polypeptide
PDGFB platelet-derived growth factor beta polypeptide
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PEBP1 phosphatidylethanolamine binding protein 1
PHB prohibitin
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
PKD2 polycystic kidney disease 2 (autosomal dominant)
PLCE1 phospholipase C, epsilon 1
POU3F2 POU class 3 homeobox 2
PRKAA1 protein kinase, AMP-activated, alpha 1 catalytic subunit
PRKCE protein kinase C, epsilon
PROK1 prokineticin 1
PROM1 prominin 1
PTCH1 patched 1
PTEN phosphatase and tensin homolog
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
RAF1 Raf-1 proto-oncogene, serine/threonine kinase
RARB retinoic acid receptor, beta
RASSF1 Ras association (RalGDS/AF-6) domain family member 1
RET ret proto-oncogene
RFFL ring finger and FYVE-like domain containing E3 ubiquitin protein ligase
RHEB Ras homolog enriched in brain
RIT2 Ras-like without CAAX 2
RND3 Rho family GTPase 3
RNF149 ring finger protein 149
RTN4 reticulon 4
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SLC34A1 solute carrier family 34 (type II sodium/phosphate cotransporter), member 1
SLC5A1 solute carrier family 5 (sodium/glucose cotransporter), member 1
SLC5A5 solute carrier family 5 (sodium/iodide cotransporter), member 5
SLC5A8 solute carrier family 5 (sodium/monocarboxylate cotransporter), member 8
SLC9A1 solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1
SMARCA2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
SND1 staphylococcal nuclease and tudor domain containing 1
SNRPE small nuclear ribonucleoprotein polypeptide E
SOX2 SRY (sex determining region Y)-box 2
SPP1 secreted phosphoprotein 1
SPRY2 sprouty homolog 2 (Drosophila)
SRC SRC proto-oncogene, non-receptor tyrosine kinase
SRSF6 serine/arginine-rich splicing factor 6
STAT1 signal transducer and activator of transcription 1, 91kDa
TERT telomerase reverse transcriptase
TIMP3 TIMP metallopeptidase inhibitor 3
TNF tumor necrosis factor
TP53 tumor protein p53
TP73 tumor protein p73
TSC2 tuberous sclerosis 2
TTF1 transcription termination factor, RNA polymerase I
TWIST1 twist family bHLH transcription factor 1
VANGL2 VANGL planar cell polarity protein 2
VEGFA vascular endothelial growth factor A
WNT5A wingless-type MMTV integration site family, member 5A